Navigation Links
Obesity increases risk of prostate cancer recurrence for both blacks and whites
Date:8/13/2009

DURHAM, N.C. A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.

Studies have shown that obesity is linked to generally worse outcomes in many cancers, including prostate cancer. Because blacks are more likely than whites to develop and die from prostate cancer and because there is a higher prevalence of obesity among black men with prostate cancer, compared to whites some studies have suggested that obesity might be a more ominous risk factor for blacks than whites.

"Not so," says Stephen Freedland, M.D., an associate professor of urology and pathology in the Duke Prostate Center and the senior author of the study appearing in the journal Cancer. "Obesity leads to worse cancer in both groups."

Freedland and Jayakrishnan Jayachandran, M.D. a urologic oncology fellow at Duke and the lead author of the paper, examined the records of 1,415 men enrolled in the Shared Equal Access Regional Cancer Hospital (SEARCH) database who had undergone a radical prostatectomy. Black men comprised almost half (47 percent) of the sample.

After adjusting for various preoperative characteristics, researchers analyzed the relationship between body mass index (BMI) and the aggressiveness of the cancer, as measured by the risk of recurrence. In contrast to other studies, investigators found no association between race and obesity.

Almost a third of the men were obese, regardless of race. "We found that higher BMI was associated with significantly increased risk of cancer recurrence for both blacks and whites," said Jayachandran. "Though prior SEARCH-based studies from our group found that obesity was associated with a higher risk of disease progression as measured by a rising PSA after surgery, it now appears that being obese just means a poorer prognosis, period, regardless of race."

As for why that might be, Jayachandran says he's not sure, but he says it may have something to do with altered hormone levels.

"Obesity is associated with more estrogen and less testosterone, and it may be that lower testosterone promotes more aggressive tumors as recent studies have suggested." In addition, Jayachandran says alteration in the production of other hormones, like insulin, insulin-like growth factor or leptin, which occur in obese men, may also be involved in the development of more aggressive tumors. "This is something we simply do not understand, but we are actively studying all of these factors."


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Introducing All-New IEHP Superhero to Battle Childhood Obesity
2. The Obesity Society Position on Recent Criticism of Surgeon General Nominee Regina Benjamin
3. America Takes on the Challenge to Fight Obesity
4. YMCA of the USA Announces 16 Communities Selected for Statewide Policy Change Initiative to Reverse the Childhood Obesity Epidemic
5. Ten Professional Societies Join Forces to Develop Obesity Medicine Certification Examination
6. Tennessee's New Life Center for Bariatric Surgery Launches Comprehensive Website Reaching out to Sufferers of Morbid Obesity
7. Kaiser Permanente Honored for Efforts to Combat Obesity With 2009 Pioneering Innovation Award at Weight of the Nation Conference
8. CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards
9. More Can Be Done to Slow Obesitys Toll on Health: Experts
10. Highmark Provides Pediatricians With Resources to Combat Childhood Obesity
11. Almost 10 Percent of U.S. Medical Costs Tied to Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... a2z, Inc. is ... and Canadian Association for Enterostomal Therapy (CAET) will be utilizing powerful and innovative ... to attendees and exhibitors for the 2016 WOCN Society & CAET Joint Conference—which ...
(Date:5/4/2016)... ... May 04, 2016 , ... Washington Wellness Center today ... central New Jersey residents. What started out as an idea to provide a ... integrated approach to healthcare. , Developed by Dr. David Swanekamp, Chiropractic Physician , ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... is transforming breastfeeding for nursing mothers. The company’s patented technology, The Smart Breastfeeding ... Today, the company announced that the technology is now available for purchase at ...
(Date:5/4/2016)... ... ... Natalie Jill is a well respected lifestyle mentor and fitness ... of her new book: Natalie Jill’s 7 Day Jump Start: Unprocess Your Diet . ... a new healthy lifestyle featuring simple recipes using MitoXcell’s raw cacao formula. , ...
(Date:5/4/2016)... ... ... Advanced Spine & Sport Medical Rehabilitation Center, which is renowned for its ... seminar on stem cell injections. The seminar is scheduled for Wednesday, May 18, from ... Suite 110, Ventura, CA. There are only 10 seats available. , “The purpose ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
(Date:5/3/2016)... Pharmaceutical giant Johnson & Johnson ... woman who says its talc-based powder products caused ovarian ... $5 million in compensatory damages and $50 million ... ) , This is the second ... February, the same court awarded $72 million to the ...
(Date:5/3/2016)... Utah , May 3, 2016  Forté Elements, LLC (Forté) is excited to ... nutritional products that address the nutritional needs of recovery for a variety of clinical ... products. Photo - http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology: