Navigation Links
Obesity in dads may be associated with offspring's increased risk of disease
Date:2/5/2013

DURHAM, N.C. -- A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine.

The study, which appears Feb. 6 in the journal BMC Medicine, is the first in humans to show that paternal obesity may alter a genetic mechanism in the next generation, suggesting that a father's lifestyle factors may be transmitted to his children.

"Understanding the risks of the current Western lifestyle on future generations is important," said molecular biologist Adelheid Soubry, PhD, a postdoctoral associate at Duke Cancer Institute and the study's lead author. "The aim of this study was to determine potential associations between obesity in parents prior to conception and epigenetic profiles in offspring, particularly at certain gene regulatory regions."

Researchers looking at health outcomes in newborns have historically focused on pregnant women. Studies have shown that nutrition and environmental factors during pregnancy can affect children's health and may raise their risk of chronic diseases. However, little has been done to uncover how paternal factors can affect children.

The Duke research team sought to determine associations between obesity in parents and changes in DNA methylation at the insulin-like growth factor 2 (IGF2) gene among offspring. DNA methylation regulates the activity of certain genes, which can reflect a higher risk for some diseases. Decreased DNA methylation at the IGF2 gene has been associated with an increased risk of developing certain cancers, including colorectal and ovarian cancers.

"Our genes are able to adapt to our environment. However, we adjust in a way that may be problematic later," said Cathrine Hoyo, PhD, MPH, a cancer epidemiologist at Duke Medicine and the study's senior author. "It is not a change in the sequence of the DNA itself, but how genes are expressed. Some genes may get 'shut off' as a result of environmental trauma."

To gather data on newborn health outcomes, the researchers followed families enrolled in the Newborn Epigenetics Study (NEST), a research program developed by Hoyo and funded by the National Institutes of Health to test the influence of environmental exposures on genetic profiles in newborns.

Researchers gathered information about the mothers and fathers using questionnaires and medical records. They then examined DNA from the umbilical cords of 79 newborns to determine potential associations between the offspring's DNA methylation patterns and parental obesity before conception.

DNA methylation at the IGF2 gene in the offspring of obese fathers was significantly lower than in the children of fathers who were not obese. This suggests that paternal obesity may be associated with an increased risk of children developing certain cancers.

The researchers noted that the changes in DNA methylation could have been a result of something related to obesity, such as eating a certain diet or having diabetes, that was not measured in this study.

Additional research is underway to see if these changes in DNA methylation at the IGF2 gene remain as the children grow older. Future studies may also determine if certain interventions similar to women taking folic acid while pregnant to prevent birth defects can be used prior to or after conception to prevent irregular methylation profiles.

"This study is an important start in looking at the effects of environmental exposure on children, not only through the mother but also through the father," said Soubry. "Although we cannot define at this point which obesity-related factor may cause an epigenetic effect, we measured in this study a significant association between paternal obesity and aberrant methylation profiles in the offspring."


'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Vitamin D Loss Attributed to Obesity
2. Obesity treatment breakthrough described in EurekAlert!s No. 1 most-visited news release in 2012
3. Samoan obesity epidemic starts at birth
4. Old age offers no protection from obesitys death grip
5. Kaiser Permanentes anti-obesity interventions in schools show signs of success
6. Obesity May Be Linked to MS Risk in Children
7. Fetal exposure to tributyltin linked to obesity
8. More Time at Family Dinners Might Curb Obesity in Kids
9. Bioethics leader calls for bold approach to fighting obesity
10. Childhood Obesity Rates Drop in New York City, Los Angeles: Study
11. Gastric banding an effective long-term solution to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: