Navigation Links
Obesity in dads may be associated with offspring's increased risk of disease
Date:2/5/2013

DURHAM, N.C. -- A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine.

The study, which appears Feb. 6 in the journal BMC Medicine, is the first in humans to show that paternal obesity may alter a genetic mechanism in the next generation, suggesting that a father's lifestyle factors may be transmitted to his children.

"Understanding the risks of the current Western lifestyle on future generations is important," said molecular biologist Adelheid Soubry, PhD, a postdoctoral associate at Duke Cancer Institute and the study's lead author. "The aim of this study was to determine potential associations between obesity in parents prior to conception and epigenetic profiles in offspring, particularly at certain gene regulatory regions."

Researchers looking at health outcomes in newborns have historically focused on pregnant women. Studies have shown that nutrition and environmental factors during pregnancy can affect children's health and may raise their risk of chronic diseases. However, little has been done to uncover how paternal factors can affect children.

The Duke research team sought to determine associations between obesity in parents and changes in DNA methylation at the insulin-like growth factor 2 (IGF2) gene among offspring. DNA methylation regulates the activity of certain genes, which can reflect a higher risk for some diseases. Decreased DNA methylation at the IGF2 gene has been associated with an increased risk of developing certain cancers, including colorectal and ovarian cancers.

"Our genes are able to adapt to our environment. However, we adjust in a way that may be problematic later," said Cathrine Hoyo, PhD, MPH, a cancer epidemiologist at Duke Medicine and the study's senior author. "It is not a change in the sequence of the DNA itself, but how genes are expressed. Some g
'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vitamin D Loss Attributed to Obesity
2. Obesity treatment breakthrough described in EurekAlert!s No. 1 most-visited news release in 2012
3. Samoan obesity epidemic starts at birth
4. Old age offers no protection from obesitys death grip
5. Kaiser Permanentes anti-obesity interventions in schools show signs of success
6. Obesity May Be Linked to MS Risk in Children
7. Fetal exposure to tributyltin linked to obesity
8. More Time at Family Dinners Might Curb Obesity in Kids
9. Bioethics leader calls for bold approach to fighting obesity
10. Childhood Obesity Rates Drop in New York City, Los Angeles: Study
11. Gastric banding an effective long-term solution to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... May 03, 2015 NuevaCare announced today ... two upcoming area seminars. The first event will take ... Regional Stroke Conference to be held at The Magnolia ... Wednesday, May 13 during the Dementia Conference to be ... “These seminars offer an excellent opportunity to learn about ...
(Date:5/3/2015)... HealthPostures, a pioneering ergonomics company that ... the , May 5 - 7, 2015 Minnesota Safety ... the conference include its bestselling TaskMate sit stand solutions. ... 6100 TaskMate Executive. Features of the 6100 TaskMate Executive ... extended platform work surface and supply holders. Weighing 50 ...
(Date:5/2/2015)... May 02, 2015 Vancouver fencing company, QS ... provide valuable advice to prospective clients related to their questions ... to install railings around their decks and patios. While that ... that pop up once the person rolls up their sleeve ... installing a railing in finding a gate that matches it. ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 It’s a ... deadly natural disaster strikes anywhere on this planet, cyber ... human sympathy and compassion for their own personal gain. ... Computer Emergency Readiness Team) issued an alert titled ... potential email scams citing the earthquake in Nepal. The ...
(Date:5/2/2015)... Ohio (PRWEB) May 02, 2015 On ... Liverpool City Hospital (ELCH) gathered to celebrate improvements in ... River Valley Health Partners (RVHP), had zero acquired ventilator ... urinary catheter associated infections. ELCH was also recently named ... The management team at ELCH credited the teamwork of ...
Breaking Medicine News(10 mins):Health News:NuevaCare Introduces MnemeTherapy® Approach to Care for Elderly Patients with Alzheimer’s, Stroke and Other Types of Neurodegenerative Conditions 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... lower risk of ischemic heart disease or stroke. They remain ... to consume more alcohol., ,This research was reported in ... Health., ,Researchers for the study had said that milk ... of its association with cholesterol levels. However people should not ...
... out that sex differences in sleep patterns do exist, with ... carried out a national survey of 39,588 people of the ... of Taiwan. The researchers considered several factors other than gender ... ,The results of the study had shown that there is ...
... reported that in manning the progress of osteoarthritis// of the ... hip involves joint space narrowing that is accompanied by severe ... lead to total hip replacement operation in patients who may ... process of disease progression. ,The researchers had studied ...
... coughs for months or even// years have a high possibility ... the researchers of Montefiore Cough Center, US, have reported that ... average of nine years, 53% of them were also suffering ... Thoracic Society International Conference 2005. ,The researchers did a ...
... scientists have reported that delaying pregnancy may result in ... and more women deciding to put off pregnancy for ... pregnancy for women across the globe. Delaying in getting ... abnormal number of chromosomes, and other conditions. This is ...
... The Lancet that for identifying the risk of breast cancer ... their families, MRI scanning does score more than mammography. ... breast cancer are predisposed to the disease genetically. These women ... adulthood. Screening young women for this purpose is done more ...
Cached Medicine News:
(Date:4/30/2015)... MOUNTAIN VIEW, Calif., April 30, 2015 Omnicell, Inc. ... and supply management solutions to healthcare systems, today announced ... GAAP results: Revenue for the first quarter ... 14.2% from the first quarter of 2014, and down ... 2014. First quarter 2015 net income as ...
(Date:4/30/2015)... VIEW, Calif. , April 30, 2015  IRIDEX ... will release its first quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:4/30/2015)... PLEASANTON, Calif. , April 30, 2015  Thoratec ... mechanical circulatory support therapies to save, support and restore ... Bank of America Merrill Lynch 2015 Healthcare Conference on ... , President and Chief Executive Officer, will provide an ... Daylight time (1:40 p.m., Eastern Daylight Time). ...
Breaking Medicine Technology:Omnicell Announces First Quarter 2015 Results 2Omnicell Announces First Quarter 2015 Results 3Omnicell Announces First Quarter 2015 Results 4Omnicell Announces First Quarter 2015 Results 5Omnicell Announces First Quarter 2015 Results 6Omnicell Announces First Quarter 2015 Results 7Omnicell Announces First Quarter 2015 Results 8Omnicell Announces First Quarter 2015 Results 9Omnicell Announces First Quarter 2015 Results 10Omnicell Announces First Quarter 2015 Results 11Omnicell Announces First Quarter 2015 Results 12Omnicell Announces First Quarter 2015 Results 13Omnicell Announces First Quarter 2015 Results 14Omnicell Announces First Quarter 2015 Results 15Omnicell Announces First Quarter 2015 Results 16Omnicell Announces First Quarter 2015 Results 17Omnicell Announces First Quarter 2015 Results 18Omnicell Announces First Quarter 2015 Results 19Omnicell Announces First Quarter 2015 Results 20Omnicell Announces First Quarter 2015 Results 21Omnicell Announces First Quarter 2015 Results 22Omnicell Announces First Quarter 2015 Results 23Omnicell Announces First Quarter 2015 Results 24Omnicell Announces First Quarter 2015 Results 25Omnicell Announces First Quarter 2015 Results 26Omnicell Announces First Quarter 2015 Results 27IRIDEX Announces First Quarter 2015 Conference Call and Release Date 2Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2
... The Pharmaceutical Research and Manufacturers of America (PhRMA) today ... Board of Directors. "We are pleased to ... of Directors," said PhRMA President and Chief Executive Officer ... most research-intensive sectors in the U.S., they bring to ...
... Spectros white LED patent was validated during reexamination by the ... In a reexamination of U.S. Patent No. 6,711,426, the ... in medical spectroscopy is unique and protectable, and that certain ... under this Spectros patent. "This is a broad ...
Cached Medicine Technology:PhRMA Elects Four New Members to Board of Directors 2PhRMA Elects Four New Members to Board of Directors 3Spectros White LED Patent Scope Affirmed In U.S. Patent Office Reexamination 2
... great versatility in epilation and the ... compactness and easy-transportability of the system. ... developed for Smartepil II plus, and ... for hair removal of tricky areas ...
... new and efficient method applied to dermatological ... ongoing research and development with hundreds of ... light source, but rather a platform for ... horizons in pulsed-light-based technology, the most valid ...
Auto Refkeratomoeter...
The convenience of safe and precise Patient Controlled Analgesia in a flexible system designed with advanced technology. This is progressive, innovative, and effective pain management in a sophistica...
Medicine Products: