Navigation Links
Obesity in dads may be associated with offspring's increased risk of disease
Date:2/5/2013

DURHAM, N.C. -- A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine.

The study, which appears Feb. 6 in the journal BMC Medicine, is the first in humans to show that paternal obesity may alter a genetic mechanism in the next generation, suggesting that a father's lifestyle factors may be transmitted to his children.

"Understanding the risks of the current Western lifestyle on future generations is important," said molecular biologist Adelheid Soubry, PhD, a postdoctoral associate at Duke Cancer Institute and the study's lead author. "The aim of this study was to determine potential associations between obesity in parents prior to conception and epigenetic profiles in offspring, particularly at certain gene regulatory regions."

Researchers looking at health outcomes in newborns have historically focused on pregnant women. Studies have shown that nutrition and environmental factors during pregnancy can affect children's health and may raise their risk of chronic diseases. However, little has been done to uncover how paternal factors can affect children.

The Duke research team sought to determine associations between obesity in parents and changes in DNA methylation at the insulin-like growth factor 2 (IGF2) gene among offspring. DNA methylation regulates the activity of certain genes, which can reflect a higher risk for some diseases. Decreased DNA methylation at the IGF2 gene has been associated with an increased risk of developing certain cancers, including colorectal and ovarian cancers.

"Our genes are able to adapt to our environment. However, we adjust in a way that may be problematic later," said Cathrine Hoyo, PhD, MPH, a cancer epidemiologist at Duke Medicine and the study's senior author. "It is not a change in the sequence of the DNA itself, but how genes are expressed. Some genes may get 'shut off' as a result of environmental trauma."

To gather data on newborn health outcomes, the researchers followed families enrolled in the Newborn Epigenetics Study (NEST), a research program developed by Hoyo and funded by the National Institutes of Health to test the influence of environmental exposures on genetic profiles in newborns.

Researchers gathered information about the mothers and fathers using questionnaires and medical records. They then examined DNA from the umbilical cords of 79 newborns to determine potential associations between the offspring's DNA methylation patterns and parental obesity before conception.

DNA methylation at the IGF2 gene in the offspring of obese fathers was significantly lower than in the children of fathers who were not obese. This suggests that paternal obesity may be associated with an increased risk of children developing certain cancers.

The researchers noted that the changes in DNA methylation could have been a result of something related to obesity, such as eating a certain diet or having diabetes, that was not measured in this study.

Additional research is underway to see if these changes in DNA methylation at the IGF2 gene remain as the children grow older. Future studies may also determine if certain interventions similar to women taking folic acid while pregnant to prevent birth defects can be used prior to or after conception to prevent irregular methylation profiles.

"This study is an important start in looking at the effects of environmental exposure on children, not only through the mother but also through the father," said Soubry. "Although we cannot define at this point which obesity-related factor may cause an epigenetic effect, we measured in this study a significant association between paternal obesity and aberrant methylation profiles in the offspring."


'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Vitamin D Loss Attributed to Obesity
2. Obesity treatment breakthrough described in EurekAlert!s No. 1 most-visited news release in 2012
3. Samoan obesity epidemic starts at birth
4. Old age offers no protection from obesitys death grip
5. Kaiser Permanentes anti-obesity interventions in schools show signs of success
6. Obesity May Be Linked to MS Risk in Children
7. Fetal exposure to tributyltin linked to obesity
8. More Time at Family Dinners Might Curb Obesity in Kids
9. Bioethics leader calls for bold approach to fighting obesity
10. Childhood Obesity Rates Drop in New York City, Los Angeles: Study
11. Gastric banding an effective long-term solution to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
(Date:10/12/2017)... ... ... Health Literacy Innovations (HLI), creator of the Health Literacy ... Patient Education Network (CPEN), an independent professional organization that shares best practices in ... , As CPEN’s strategic partner, HLI will help support CPEN members by sharing ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
Breaking Medicine Technology: