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Obesity in Middle Age Tied to More Rapid Mental Decline: Study
Date:8/20/2012

rology.

People with metabolic syndrome who were also obese saw a more rapid decline -- 22.5 percent faster -- in their mental function than those who weren't obese and didn't suffer from the syndrome.

Moreover, those who did not have metabolic syndrome but were obese also saw mental function decline more quickly than participants who were not obese.

Obesity is a known risk factor for many adverse health outcomes, including dementia. It typically is accompanied by metabolic syndrome, Singh-Manoux said. This, however, is not always the case, leading to the concept of so-called "metabolically healthy obesity," she said.

"Some research suggests this type of obesity carries less health risk, but the evidence is far from clear," Singh-Manoux said.

"Our results show this not to be the case for mental function," she said. "Obesity, in those who were metabolically healthy and unhealthy, was associated with poor mental function at the start of the study and greater decline over 10 years."

Dr. Richard Lipton, professor and vice chairman of neurology at Albert Einstein College of Medicine in New York City, said that "this study suggests that taking the steps recommended to prevent heart attack and stroke in midlife, including controlling body weight, high blood pressure, diabetes and lipid profiles, may also have a beneficial effect on cognitive function late in life."

Although more studies are needed, people should heed the advice on how to protect their hearts, Lipton said, which will, in turn, protect their brains as well.

"Maintaining normal body weight while preventing or treating abnormalities in blood pressure, glucose regulation and lipids may provide a therapeutic twofer, protecting the heart and brain," he said.

More information

To learn more about obesity, visit the U.S. National Library of Medicine.


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