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'Obesity genes' may influence food choices, eating patterns
Date:5/23/2012

PROVIDENCE, R.I. Blame it on your genes? Researchers from The Miriam Hospital's Weight Control and Diabetes Research Center say individuals with variations in certain "obesity genes" tend to eat more meals and snacks, consume more calories per day and often choose the same types of high fat, sugary foods.

Their study, published online by the American Journal of Clinical Nutrition and appearing in the June issue, reveals certain variations within the FTO and BDNF genes which have been previously linked to obesity may play a role in eating habits that can cause obesity.

The findings suggest it may be possible to minimize genetic risk by changing one's eating patterns and being vigilant about food choices, in addition to adopting other healthy lifestyle habits, like regular physical activity.

"Understanding how our genes influence obesity is critical in trying to understand the current obesity epidemic, yet it's important to remember that genetic traits alone do not mean obesity is inevitable," said lead author Jeanne M. McCaffery, Ph.D., of The Miriam Hospital's Weight Control and Diabetes Research Center.

"Our lifestyle choices are critical when it comes to determining how thin or heavy we are, regardless of your genetic traits," she added. "However, uncovering genetic markers can possibly pinpoint future interventions to control obesity in those who are genetically predisposed."

Previous research has shown individuals who carry a variant of the fat mass and obesity-associated gene FTO and BDNF (or brain-derived neurotrophic factor gene) are at increased risk for obesity. The genes have also been linked with overeating in children and this is one of the first studies to extend this finding to adults. Both FTO and BDNF are expressed in the part of the brain that controls eating and appetite, although the mechanisms by which these gene variations influence obesity is still unknown.

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Contact: Jessica Collins Grimes
jgrimes2@lifespan.org
401-793-7484
Lifespan
Source:Eurekalert

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