Navigation Links
Obesity gene linked to hormonal changes that favor energy surplus
Date:6/11/2014

A new study from Uppsala University demonstrates that elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight. The findings are published in the journal Diabetes.

In the Prospective Investigation of the Vasculature in Uppsala Seniors, researchers from Uppsala University and the University of Ume used data from 985 elderly participants (50% females) with an average age of 70 years to examine whether circulating levels of ghrelin and leptin, measured after an overnight fast, are linked to a common variant of FTO.

"We found that elderly carrying an obesity-susceptible variant of the FTO gene had plasma ghrelin levels that were approximately 9 percent higher than in non-carriers. In contrast, serum levels of the satiety enhancing hormone leptin were roughly 11 percent lower", says Christian Benedict, researcher at Uppsala University.

"The present findings suggest that this FTO variant may facilitate weight gain in humans by shifting the endocrine balance from the satiety hormone leptin toward the hunger promoting hormone ghrelin", says Christian Benedict.


'/>"/>
Contact: Christian Benedict
christian.benedict@neuro.uu.se
46-072-705-9019
Uppsala University
Source:Eurekalert

Page: 1

Related medicine news :

1. Parent and child must get enough sleep to protect against child obesity
2. Research helps clarify how obesity leads to type 2 diabetes, cancer
3. Where one lives matters in the relationship between obesity and life satisfaction
4. What what role does MSG play in obesity and fatty liver disease?
5. Chronic insufficient sleep increases obesity, overall body fat in children
6. Obesity associated with longer hospital stays, higher costs in total knee replacement patients
7. Obesity drug failing patients due to lack of education about side-effects
8. Childhood obesity trends -- not time to celebrate, yet
9. Linking vascular inflammation to obesity and atherosclerosis
10. Snacking contributes to fatty liver and abdominal obesity
11. Early obesity linked to increased probability of severe obesity later in life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 24, 2017 , ... STATEMENT OPPOSING PRESIDENT DONALD TRUMP’S 2018 ... Trump’s budget, “A New Foundation for American Greatness—President's Budget FY 2018,” because it ... underserved populations, undermines productivity, and destroys the social safety net needed by hardworking ...
(Date:5/24/2017)... ... 2017 , ... Accordant Technology, a trusted IT solutions provider, ... analytics-first approach, layered with machine learning, that provides real-time visibility into the performance, ... to the edge. Through the new partnership, customers get the real-time situational insight ...
(Date:5/24/2017)... Wisconsin (PRWEB) , ... May 24, 2017 , ... ... in clean label food ingredient solutions for the food and beverage industry offers ... in food ingredient statements during the purchasing decision process. As a result, labels ...
(Date:5/23/2017)... ... 2017 , ... Allegheny Health Network and the Alexis Joy ... Women’s Behavioral Health at West Penn Hospital , a unique facility that will ... pregnancy-related depression. Construction of the Center is underway with a scheduled opening in ...
(Date:5/23/2017)... ... May 23, 2017 , ... The National Council on ... to announce the organization’s Certified Strength Coach credential has earned accreditation from the ... program validates the competency of qualified candidates for jobs in the Strength and ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/8/2017)... , May 8, 2017 MACRA ... transition from fee for service reimbursement. Black Book Research ... 1.       The Market for MIPS Compliance ... 77% of physician practices with 3 or more clinicians ... Solutions by Q4. "Given the magnitude of the changes, ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology: