Navigation Links
Obesity does not worsen asthma, but may reduce response to medications
Date:6/2/2009

Being overweight or obese does not make asthma worse in patients with mild and moderate forms of the disease, according to a study by National Jewish Health researchers, although it may reduce the response to medications.

"With both asthma and obesity on the rise in recent years, there has been much interest in the possible link between these two conditions," said lead author E. Rand Sutherland, Associate Professor of Medicine at National Jewish Health. "By studying a well characterized group of patients with asthma, we were able to determine that increased weight is not associated with more severe asthma. Although benefits can be obtained with weight loss in other diseases, these findings suggest that an improvement in asthma may not necessarily result from weight loss."

"The findings also suggest that patients and physicians should be aware that obese asthma patients may not respond well to corticosteroids, the most successful controller medication for asthma, which can affect dosing decisions and choices of possible alternatives to steroids."

Previous studies have suggested that obesity predisposes people to developing asthma, to suffer more severe asthma symptoms, and to respond less to medications. However, the exact mechanism for these links has been unclear, and the studies have generally relied upon patients' reports of their diagnosis and symptoms rather than using more precise tools to characterize patients.

Dr. Sutherland and his colleagues decided to examine the issue in a well characterized group of 1,256 patients who had participated in NIH-sponsored studies. They divided them into patients with a body mass index of less than 25 (lean) and greater than or equal to 25 (overweight and obese). They found that lean asthma patients had slightly greater forced expiratory volume in one second , or FEV1 (3.05 liters vs 2.91 liters), and slightly greater ratio of FEV1 to forced vital capacity (83.5% vs. 82.4%), both common measures of lung function. They also found slightly greater use of rescue inhalers among overweight patients (1.2 puffs per day vs. 1.1 puffs per day) and slightly higher scores asthma-relate quality of life questionnaires (5.77 vs. 5.59).

"These differences were small and are unlikely to be of any real clinical significance," said Dr. Sutherland.

Response to medications, however, did show an effect of increased weight. Among a subgroup of 183 people, lean patients taking inhaled corticosteroids alone showed a 55% greater reduction in exhaled nitric oxide, a measure of inflammation. Lean patients taking a combination inhaled steroid and long-acting beta agonist increased their FEV1 by 80 more milliliters. There were no differences, however, between these patients in the number of asthma exacerbations.

"The data suggest overweight and obese people respond less well to controller medications for asthma than do their lean counterparts," said Dr. Sutherland. "These data come from already-completed studies designed to answer other questions, however, and ongoing studies are being conducted to more definitively determine the effect of increased weight on treatment response in asthma."


'/>"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
10. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
11. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... California (PRWEB) , ... January 17, 2017 , ... ... have a point of difference. Eden Activewear is a stand-out company for several ... are exclusively online and only manufacture on demand, this is called 'Agile' manufacturing ...
(Date:1/17/2017)... ... , ... Kevin Harrington (one of the original Sharks from mega-hit reality series ... topic of Beauty and Personal Care. , Everyone makes New Year’s ... commit to these changes than beginning with personal care and beauty products? AsSeenOnTV.pro will ...
(Date:1/17/2017)... Lehi, Utah (PRWEB) , ... January 17, 2017 ... ... provider of accredited, online continuing education for EMS and firefighting professionals, has released ... Training (VILT) Solution. These new courses are taught live in an online classroom ...
(Date:1/17/2017)... ... ... Neil H. Greco Insurance Agency, a northern New Jersey firm that provides ... a charity drive to raise awareness of heart disease and promote habits that improve ... is responsible for 1 in every 4 deaths at the national level each year. ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... breast cancer survivor Sandra Lee as keynote speaker for the 34th Annual Miami ... , In making the announcement, PER® president, Phil Talamo, said, “We are delighted ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017 Paragon Bioservices ... provide product development services for a variety of ... (NIAID) medical product development activities. The IDIQ ... contractor pool for task order awards up to ... leader in manufacturing and process development of biopharmaceuticals, ...
(Date:1/17/2017)... -- Management to Discuss Acquisition of ... KIT-302 Development On Track For An NDA Submission ... Q1 2017   ... Ltd. (NASDAQ: KTOV ; TASE: KTOV), an innovative biopharmaceutical company, announced ... at 8:30am Eastern Time to discuss the recent acquisition of a majority ...
(Date:1/17/2017)... DUBLIN , Jan. 17, 2017  Jazz Pharmaceuticals ... first patient has been enrolled in a Phase 3 ... versus best supportive care (BSC) in the prevention of ... undergoing hematopoietic stem cell transplant (HSCT) who are at ... VOD.  The defibrotide clinical trial will be conducted across ...
Breaking Medicine Technology: