Navigation Links
Obesity does not worsen asthma, but may reduce response to medications
Date:6/2/2009

Being overweight or obese does not make asthma worse in patients with mild and moderate forms of the disease, according to a study by National Jewish Health researchers, although it may reduce the response to medications.

"With both asthma and obesity on the rise in recent years, there has been much interest in the possible link between these two conditions," said lead author E. Rand Sutherland, Associate Professor of Medicine at National Jewish Health. "By studying a well characterized group of patients with asthma, we were able to determine that increased weight is not associated with more severe asthma. Although benefits can be obtained with weight loss in other diseases, these findings suggest that an improvement in asthma may not necessarily result from weight loss."

"The findings also suggest that patients and physicians should be aware that obese asthma patients may not respond well to corticosteroids, the most successful controller medication for asthma, which can affect dosing decisions and choices of possible alternatives to steroids."

Previous studies have suggested that obesity predisposes people to developing asthma, to suffer more severe asthma symptoms, and to respond less to medications. However, the exact mechanism for these links has been unclear, and the studies have generally relied upon patients' reports of their diagnosis and symptoms rather than using more precise tools to characterize patients.

Dr. Sutherland and his colleagues decided to examine the issue in a well characterized group of 1,256 patients who had participated in NIH-sponsored studies. They divided them into patients with a body mass index of less than 25 (lean) and greater than or equal to 25 (overweight and obese). They found that lean asthma patients had slightly greater forced expiratory volume in one second , or FEV1 (3.05 liters vs 2.91 liters), and slightly greater ratio of FEV1 to forced vital capacity (83.5% vs. 82.4%), both common measures of lung function. They also found slightly greater use of rescue inhalers among overweight patients (1.2 puffs per day vs. 1.1 puffs per day) and slightly higher scores asthma-relate quality of life questionnaires (5.77 vs. 5.59).

"These differences were small and are unlikely to be of any real clinical significance," said Dr. Sutherland.

Response to medications, however, did show an effect of increased weight. Among a subgroup of 183 people, lean patients taking inhaled corticosteroids alone showed a 55% greater reduction in exhaled nitric oxide, a measure of inflammation. Lean patients taking a combination inhaled steroid and long-acting beta agonist increased their FEV1 by 80 more milliliters. There were no differences, however, between these patients in the number of asthma exacerbations.

"The data suggest overweight and obese people respond less well to controller medications for asthma than do their lean counterparts," said Dr. Sutherland. "These data come from already-completed studies designed to answer other questions, however, and ongoing studies are being conducted to more definitively determine the effect of increased weight on treatment response in asthma."


'/>"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
10. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
11. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2017)... ... September 23, 2017 , ... A ... fighting obesity of Robert Kushner, director of Chicago’s Center for Lifestyle Medicine at ... healthier habits, the article notes that the center routinely recommends weight loss surgeries ...
(Date:9/23/2017)... ... September 23, 2017 , ... “You Can't Win Them All”: the ... their business ventures and on the ice changed the lives of young athletes. ... Cosimo Filane was born and educated in Schreiber, a small town in Northern Ontario, ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... On Sunday, ... Walk and 5K honoring Olympian, Florence Joyner, still considered the fastest woman of all ... Flo Jo’s daughter, Mary Joyner, will sing the National Anthem. Mary was ...
(Date:9/22/2017)... Plano, TX (PRWEB) , ... September 22, 2017 , ... ... created to strengthen the communities they serve as part of the nationally recognized ‘Agents ... by working closely with nonprofit organizations and community leaders to seek out those who ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... and financial setbacks, a senior finds a new lease on life with assistance ... thousands of people resolve their problem with unsecured debt. The senior is one ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 2017  Medical professionals are expected to ... treating their patients. Medical simulations offer clinicians ... patients. Simulation provides a safe method for ... procedures, refine techniques and build confidence, without ... technology, such as augmented reality, will now ...
(Date:9/6/2017)... Eli Lilly and Company (NYSE: ... for galcanezumab and lasmiditan, two investigational treatments for migraine, ... (IHC) taking place Sept. 7-10 in Vancouver ... long-term data from an open-label study evaluating the safety ... and 240 mg) for the prevention of migraine. Galcanezumab ...
(Date:9/5/2017)... Sept. 5, 2017  Getinge, a leading global ... vibrant charitable donation program -- "Color for the ... heart defect research by The Children,s Heart Foundation. ... general public are encouraged to download a coloring ... completed artwork to the gallery on the website. ...
Breaking Medicine Technology: