Navigation Links
Obesity before pregnancy linked to earliest preterm births, Stanford/Packard study finds
Date:6/25/2014

Women who are obese before they become pregnant face an increased risk of delivering a very premature baby, according to a new study of nearly 1 million California births.

The findings from the Stanford University School of Medicine provide important clues as to what triggers extremely preterm births, specifically those that occur prior to 28 weeks of pregnancy.

The study, published in the July issue of Paediatric and Perinatal Epidemiology, found no link between maternal obesity and premature births that happen between 28 and 37 weeks of the normal 40-week gestation period. The disparity suggests that premature birth may have different causes at different stages of pregnancy.

"Until now, people have been thinking about preterm birth as one condition, simply by defining it as any birth that happens at least three weeks early," said Gary Shaw, DrPH, professor of pediatrics and lead author of the new study. "But it's not as simple as that. Preterm birth is not one construct; gestational age matters."

Preterm births affect one in nine pregnancies, or more than a half-million U.S. babies per year. Prematurity can lead to lifelong health problems, such as cerebral palsy, developmental delays and impaired vision or hearing. Babies born before 28 weeks of pregnancy are at especially high risk.

High U.S. prematurity rates prompted the 2011 launch of the March of Dimes Prematurity Research Center at Stanford University School of Medicine, the first of five such centers the March of Dimes has planned across the country. The new findings are a product of the center's work.

The study, which examined nearly all California births between January 2007 and December 2009, was the largest ever to look for population-based links between maternal obesity and prematurity. To focus on spontaneous preterm births, the researchers excluded from analysis women who were pregnant with twins or other multiples, as well as women with illnesses previously linked to prematurity, such as diabetes, high blood pressure or preeclampsia. After these exclusions, the team had 989,697 births to analyze. Births were classified by gestational age, and many factors about the mothers were considered in the analysis, including body mass index, race/ethnicity, whether they were first-time mothers, educational attainment, when prenatal care began, source of health insurance, maternal age and maternal height.

For first-time mothers, obesity was linked with a substantial increase in risk of delivery before 28 weeks of pregnancy. The risk was highest at the earliest gestational ages and also at the highest levels of obesity. For instance, non-Hispanic, white first-time mothers in the most obese category were six times more likely than normal-weight women to deliver a baby between 20 and 23 weeks.

Obese women having their second or later child were also more likely to deliver very early than normal-weight women, though the risk was less pronounced than for first-time mothers.

"Ideally, as the American College of Obstetricians and Gynecologists has already recommended, women should embark upon a healthy diet and exercise program before becoming pregnant," said study co-author Deirdre Lyell, MD, associate professor of obstetrics and gynecology and an obstetrician at Lucile Packard Children's Hospital Stanford.

"Women who are obese should also consider meeting their obstetrician to discuss and understand the risks beyond those identified in this research," Lyell added, noting that obesity has previously been shown to raise women's risk of such pregnancy and delivery complications as gestational diabetes, preeclampsia and cesarean section.

In general, African-American women face a greater risk of preterm delivery than other populations, so the researchers were surprised to find that the effect of obesity on early preterm delivery was not explained by women's racial/ethnic background. The finding indicates that there is something about obesity itself that can trigger early birth, which may or may not be associated with other factors, such as socioeconomic patterns, that put African-American women at greater risk.

"This is a clue that informs what sort of research we should try next," Shaw said. For example, the researchers plan to investigate the role of increased inflammation from obesity because this factor cuts across racial backgrounds. "We believe the inflammatory process is contributing to preterm birth, particularly at earlier gestational ages," he said. "We're at the edge of trying to solve this puzzle."


'/>"/>

Contact: Erin Digitale
digitale@stanford.edu
650-724-9175
Stanford University Medical Center
Source:Eurekalert

Related medicine news :

1. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
2. Obesitys Health Costs Double Earlier Estimates
3. Troubled Homes May Fuel Obesity in Girls
4. Childhood Obesity May Raise Odds of Adult Liver Cancer
5. Could the Childhood Obesity Epidemic Be Ebbing?
6. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
7. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
8. Treating childhood obesity: A family affair
9. Rising Obesity Rates Might Mean More Rheumatoid Arthritis
10. Research May Point to New Obesity Treatments
11. U.S. Obesity Rate Set to Soar, Costing Billions: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
Breaking Medicine Technology: