Navigation Links
Obesity associated with lower PSA levels in men with prostate cancer
Date:11/20/2007

Higher body mass index (BMI) is associated with higher plasma volume, which may be related to lower prostate-specific antigen (PSA) levels among obese men, according to a study in the November 21 issue of JAMA.

Recent evidence has suggested that prostate cancer screening may be adversely affected by increased BMI. The ability to accurately detect prostate cancer can be compromised by any factor that decreases PSA concentration in the circulation, according to background information in the article. Several studies have found that obese men have lower PSA concentrations than non-obese men. However, men with higher BMIs also have larger plasma volumes, which could decrease serum concentrations of soluble tumor markersa phenomenon known as hemodilution, the authors write.

Lionel L. Baez, M.D., of Duke University Medical Center, Durham, N.C., and colleagues conducted a study to determine the association between hemodilution and PSA concentration in obese men with prostate cancer. The study consisted of men who underwent radical prostatectomy for prostate cancer from 1988 to 2006 and who were included in the databases of the Shared Equal Access Regional Cancer Hospital (n = 1,373), Duke Prostate Center (n = 1,974), and Johns Hopkins Hospital (n = 10,287).

The researchers found that higher BMI was significantly associated with greater plasma volume in all study populations. Men with a BMI of 35 or greater had 21 percent to 23 percent larger plasma volumes relative to normal-weight men. After adjusting for multiple clinicopathological variables, higher BMI was associated with lower pre-operative PSA concentrations in the groups. Men with a BMI of 35 or greater had 11 percent to 21 percent lower PSA concentrations relative to normal-weight men.

In 3 distinct prostate cancer cohorts, all treated by radical prostatectomy, hemodilution from increased plasma volume may be responsible for the observed decreased PSA concentration in men with higher BMI. This association needs to be confirmed prospectively in screened populations that include men without prostate cancer, the authors conclude.


'/>"/>

Contact: Lauren Shaftel Williams
919-684-4966
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. This October, the American Physical Therapy Associations National Physical Therapy Month to Focus on Nations Obesity Epidemic
10. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
11. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)...  NDS received FDA 510(k) clearance in May 2017 for its ... specifically designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... to support the improvement of patient outcomes, procedural efficiency, and the ... ... ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
Breaking Medicine Technology: