Navigation Links
Obesity associated with lower PSA levels in men with prostate cancer
Date:11/20/2007

Higher body mass index (BMI) is associated with higher plasma volume, which may be related to lower prostate-specific antigen (PSA) levels among obese men, according to a study in the November 21 issue of JAMA.

Recent evidence has suggested that prostate cancer screening may be adversely affected by increased BMI. The ability to accurately detect prostate cancer can be compromised by any factor that decreases PSA concentration in the circulation, according to background information in the article. Several studies have found that obese men have lower PSA concentrations than non-obese men. However, men with higher BMIs also have larger plasma volumes, which could decrease serum concentrations of soluble tumor markersa phenomenon known as hemodilution, the authors write.

Lionel L. Baez, M.D., of Duke University Medical Center, Durham, N.C., and colleagues conducted a study to determine the association between hemodilution and PSA concentration in obese men with prostate cancer. The study consisted of men who underwent radical prostatectomy for prostate cancer from 1988 to 2006 and who were included in the databases of the Shared Equal Access Regional Cancer Hospital (n = 1,373), Duke Prostate Center (n = 1,974), and Johns Hopkins Hospital (n = 10,287).

The researchers found that higher BMI was significantly associated with greater plasma volume in all study populations. Men with a BMI of 35 or greater had 21 percent to 23 percent larger plasma volumes relative to normal-weight men. After adjusting for multiple clinicopathological variables, higher BMI was associated with lower pre-operative PSA concentrations in the groups. Men with a BMI of 35 or greater had 11 percent to 21 percent lower PSA concentrations relative to normal-weight men.

In 3 distinct prostate cancer cohorts, all treated by radical prostatectomy, hemodilution from increased plasma volume may be responsible for the observed decreased PSA concentration in men with higher BMI. This association needs to be confirmed prospectively in screened populations that include men without prostate cancer, the authors conclude.


'/>"/>

Contact: Lauren Shaftel Williams
919-684-4966
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. This October, the American Physical Therapy Associations National Physical Therapy Month to Focus on Nations Obesity Epidemic
10. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
11. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... THR ... “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified CBD product utilizes Quicksilver ... the bloodstream. Far outpacing the absorption speed of all other products, ...
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine Review, the leading ... Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” http://www.beckersspine.com/spine-leaders/item/35348- ... in Michigan performing minimally invasive back surgery that often results in less post-operative ...
(Date:2/22/2017)... ... February 22, 2017 , ... The SeniorCare Investor will ... Forecast —on Thursday, February 23, 2017, at 1:00 PM ET. A recording of the ... of the Interactive Webinar Series. , If you want to find out what really ...
(Date:2/22/2017)... ... , ... BrightStar Care Charleston , a home care and medical staffing ... (MUSC) Center on Aging’s Senior Expo on Thursday, March 23, 2017, at the ... resource in our community. We are thrilled to participate in this event because we ...
(Date:2/22/2017)... ... February 22, 2017 , ... Physicians ... African American/Black students who want to become physicians. PMF also provides a network ... physicians in the Oakland/San Francisco Northern California, Bay Area. PMF’s mission is to ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Clean Holdings, Inc. (Nasdaq: UCTT), a leading developer ... the semiconductor capital equipment, flat panel, medical, energy ... for the fourth quarter and fiscal year ended ... year of extraordinary growth for UCT. Total revenue ... with continued focus on operational excellence resulted in ...
(Date:2/22/2017)... YORK , Feb. 22, 2017 Summary ... cord partnering deals and agreements entered into by the ... http://www.reportlinker.com/p03605680-summary/view-report.html Description The Global Spinal Cord ... and access to partnering deals and agreements entered into ... Trends in partnering deals - Top deals by ...
(Date:2/22/2017)... 2017 Summary Provides understanding ... agreements entered into by the worlds leading healthcare ... Description The Global Atherosclerosis Partnering Terms ... access to partnering deals and agreements entered into ... - Trends in partnering deals - Top ...
Breaking Medicine Technology: