Navigation Links
Obesity and weight gain near time of prostate cancer surgery doubles risk of recurrence

Johns Hopkins epidemiologists say that prostate cancer patients who gain five or more pounds near the time of their prostate surgery are twice as likely to have a recurrence of their cancer compared with patients whose weight is stable.

"We surveyed men whose cancer was confined to the prostate, and surgery should have cured most of them, yet some cancers recurred. Obesity and weight gain may be factors that tip the scale to recurrence," says Corinne Joshu, Ph.D., M.P.H., postdoctoral fellow at the Johns Hopkins Bloomberg School of Public Health.

Joshu and her colleagues sent questionnaires to 1,337 men with prostate cancer who had undergone surgery to remove their prostate at the Johns Hopkins Hospital. The researchers asked each participant to recall their dietary, lifestyle and medical factors from five years before their surgery through one year after.

Results show that men whose weight increased more than 2.2 kg (or about five pounds of total weight) during the time period had twice the rate of recurrence compared with men whose weight remained the same. On average, the study participants who gained weight reported that they gained about 10 pounds in the five years before surgery and one year postoperation.

"The good news is that being physically active reduced the risk of recurrence associated with obesity," says Elizabeth Platz, Sc.D., M.P.H., associate professor at the Johns Hopkins Bloomberg School of Public Health and co-director of cancer prevention and control at the Johns Hopkins Kimmel Cancer Center.

Platz says that there are a variety of biochemical pathways that may be active in the body depending on daily activity. These pathways also may vary in their impact depending on the stage and type of prostate cancer and timing of obesity and weight gain.

According to the researchers, study size was too small to determine whether weight loss can reverse the recurrence risk. They warn that current prostate cancer patients should heed their physician's advice on weight loss and activity near the time of surgery.

"The overriding message is one that has been repeated many times: adult men should avoid obesity and weight gain," says Platz. "Plus, it will likely have an impact on many aspects of their health."

Joshu and Platz say that several confounding factors may have had an impact in the results, including patients' ability to accurately recall their weight and lifestyle around the time of their surgery. Also, PSA values, an indicator of recurrence, tend to be lower in obese men, so physicians may be slower to detect their recurrent disease. "So, our study may be underestimating the risk of recurrent disease in these men," says Joshu.


Contact: Vanessa Wasta
Johns Hopkins Medical Institutions

Related medicine news :

1. Gladstone scientists identify target that may reduce complications of obesity
2. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
3. Doctors miss major cause of infertility and obesity
4. Cost to patients barrier to counseling for obesity and smoking
5. New study shows effectiveness of MEND program in prevention and treatment of pediatric obesity
6. NIH launches program to develop innovative approaches to combat obesity
7. Childhood obesity alone may increase risk of later cardiovascular disease
8. Link between obesity and enhanced cancer risk elucidated
9. Obesity ups cancer risk, and heres how
10. Obesity Action Coalition Calls on Insurers and Employers to Increase Access to Childhood Obesity Treatments Based on Recent United States Preventative Task Force Recommendations
11. Federal Panel Urges Obesity Screening for Kids Ages 6 and Up
Post Your Comments:
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016  VMS Rehab Systems, Inc. ( ... whatever measures required to build a strong and stable ... currently listed on the OTC Markets-pink current trading platform. ... CEO, "We are seeing an anomaly in market trading ... only by the Company, but shareholders and market players ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: