Navigation Links
Obesity and overweight linked to higher prostate cancer mortality
Date:11/11/2007

Men who are overweight or obese when diagnosed with prostate cancer are at greater risk of death after treatment, according to a new study in the December 15, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study, by Dr. Jason Efstathiou from Massachusetts General Hospital in Boston and colleagues, found that a greater body mass index (BMI) at the time of cancer diagnosis was an independent risk factor for prostate cancer-related death. Overweight and obese men (men with BMI 25 kg/m2) at the time of diagnosis were nearly twice as likely to die from locally advanced prostate cancer as patients who had a normal BMI at diagnosis.

In 2007, over 218,000 American men are expected to be diagnosed with prostate cancer and over 27,000 will die from the disease. While obesity has been identified as a risk factor for more clinically aggressive prostate cancer, the impact of obesity on survival following treatment is less understood. These treatments may include the complete surgical removal of the prostate, external beam radiation, and hormonal therapy.

Dr. Efstathiou and co-investigators reported on 788 patients with locally advanced prostate cancer followed for over 8 years to examine any independent relationship between BMI and prostate cancer-specific mortality. The study is the first to use data from a large randomized prospective treatment study with long-term follow-up to investigate this relationship.

The authors found that being overweight or obese at the time of diagnosis was a unique, independent risk factor for death from prostate cancer. Compared to men with normal BMI (BMI<25), men with BMI between 25 and 30 were more than 1.5 times more likely to die from their cancer. Similarly, men with BMI 30 were 1.6 times more likely to die from their disease compared to men with normal range BMI. After five years, the prostate cancer mortality rate for men with a normal BMI was less than seven percent compared to about 13 percent for men with BMI 25.

Dr. Efstathiou and his co-authors conclude that their data support population-based studies that report similar associations between obesity and disease-related mortality. "Further studies are warranted to evaluate the mechanisms for this increased cancer-specific mortality among overweight and obese men and to assess the impact of BMI on survival following other management strategies and in clinically localized disease. Whether weight loss after prostate cancer diagnosis alters disease course remains to be determined," conclude the authors.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
10. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
11. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... California Senate Bill (SB) 863, signed into law in 2012, ... and 2014, according to CompScope™ Medical Benchmarks for California, 17th Edition , a ... study, medical payments per claim in California decreased 4 percent in 2013 and then ...
(Date:12/8/2016)... San Francisco, California (PRWEB) , ... December 08, 2016 , ... ... health coaches, has raised an $18M Series B led by Canvas Ventures . ... use the capital to scale its mobile platform to serve more consumers who are ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Jefferson County, is announcing the launch of a ... Birmingham. , The number of homeless women and children in Birmingham has grown ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family ... in and around the Hancock County area, is announcing the launch of a charity ... , The Hancock County Food Pantry has worked for more than 30 years to ...
(Date:12/7/2016)... ... December 07, 2016 , ... DrugDev again demonstrated its dedication to ... of the early adopters completing EU-U.S. Privacy Shield Certification from the U.S. Department of ... both sides of the Atlantic with a mechanism to comply with EU data protection ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Pennsylvania Physician General ... Drug and Alcohol Programs Gary Tennis ... medications, known as benzodiazepines, developed with the help ... are medications that are frequently prescribed for anxiety ... are used with opioid pain medications, benzodiazepines pose ...
(Date:12/8/2016)... Dec. 8, 2016 True Health Diagnostics ... leading-edge laboratory services and management expertise to hospital ... , allowing more doctors and patients to benefit ... solutions. Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... systems, under pressure to contain costs, have struggled ...
(Date:12/8/2016)... NORWALK, Connecticut , 8. Dezember 2016 Mederi Therapeutics Inc ... Stretta-Therapie – eine nicht-operative Behandlungsmethode für gastroösophageale Refluxerkrankung (GERD) – in ... Reading ... Live ... by Professor Jun Liu, Director of Endoscopy at Wuhan Union Hospital ...
Breaking Medicine Technology: