Navigation Links
Obesity and overweight linked to higher prostate cancer mortality

Men who are overweight or obese when diagnosed with prostate cancer are at greater risk of death after treatment, according to a new study in the December 15, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study, by Dr. Jason Efstathiou from Massachusetts General Hospital in Boston and colleagues, found that a greater body mass index (BMI) at the time of cancer diagnosis was an independent risk factor for prostate cancer-related death. Overweight and obese men (men with BMI 25 kg/m2) at the time of diagnosis were nearly twice as likely to die from locally advanced prostate cancer as patients who had a normal BMI at diagnosis.

In 2007, over 218,000 American men are expected to be diagnosed with prostate cancer and over 27,000 will die from the disease. While obesity has been identified as a risk factor for more clinically aggressive prostate cancer, the impact of obesity on survival following treatment is less understood. These treatments may include the complete surgical removal of the prostate, external beam radiation, and hormonal therapy.

Dr. Efstathiou and co-investigators reported on 788 patients with locally advanced prostate cancer followed for over 8 years to examine any independent relationship between BMI and prostate cancer-specific mortality. The study is the first to use data from a large randomized prospective treatment study with long-term follow-up to investigate this relationship.

The authors found that being overweight or obese at the time of diagnosis was a unique, independent risk factor for death from prostate cancer. Compared to men with normal BMI (BMI<25), men with BMI between 25 and 30 were more than 1.5 times more likely to die from their cancer. Similarly, men with BMI 30 were 1.6 times more likely to die from their disease compared to men with normal range BMI. After five years, the prostate cancer mortality rate for men with a normal BMI was less than seven percent compared to about 13 percent for men with BMI 25.

Dr. Efstathiou and his co-authors conclude that their data support population-based studies that report similar associations between obesity and disease-related mortality. "Further studies are warranted to evaluate the mechanisms for this increased cancer-specific mortality among overweight and obese men and to assess the impact of BMI on survival following other management strategies and in clinically localized disease. Whether weight loss after prostate cancer diagnosis alters disease course remains to be determined," conclude the authors.


Contact: Amy Molnar

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
10. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
11. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article published ... Toronto and the University of British Columbia suggested that laws requiring bicyclists to wear ... explains that part of the reason for the controversial conclusion is that, while helmets ...
(Date:11/27/2015)... ... 2015 , ... The rapid speed at which Americans are ... care is needed, especially with Alzheimer’s, dementia and other cognitive conditions becoming more ... forgotten part of this equation: 80 percent of medical care occurs in the ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from Hopkinsville, Ky., ... medications at home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC ... In doing so, it could help to prevent potential overdose situations. As a ...
(Date:11/27/2015)... ... 2015 , ... Lizzie’s Lice Pickers just announced a special promotion that will ... their purchase of lice treatment product. In addition, customers will receive a complimentary head ... “Finding lice is a sure way to ruin the holidays, so we encourage all ...
(Date:11/27/2015)... Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... for use in Final Cut Pro X. With ProSidebar: Fasion, video editors can ... or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating drop ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... 2015 Research and Markets ( ) ... Care Market by Type (Dressings, Therapy Devices, Active Wound ... Out-Patient Facility), and Geography - Global Forecast to 2020" ... --> --> The purpose of this ... of the global advanced wound care market. It involves ...
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Italian ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
Breaking Medicine Technology: