Navigation Links
Obesity and overeating during menopause together promote breast tumor growth and progression
Date:12/7/2012

PHILADELPHIA Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research.

"Obese postmenopausal women have increased risk for breast cancer and poorer clinical outcomes compared with postmenopausal women who are lean," said Paul S. MacLean, Ph.D., associate professor of medicine at the University of Colorado Anschutz Health and Wellness Center in Aurora, Colo. "The reasons for this are not fully understood.

"Unfortunately you cannot do the studies needed to address this issue in humans. So, we merged rat models of obesity, breast cancer and menopause to best mimic the events that link premenopausal obesity to an increased rate of postmenopausal breast cancer."

During menopause, women often gain weight because they consume more food than their body needs. In a previous study, MacLean and colleagues used their rat model to show that weight gain following surgical ovariectomy, which models menopause, helped promote breast tumor development in obese rats.

In this study, they confirmed that obesity and overfeeding after surgical ovariectomy together drove aggressive tumor growth and progression.

One reason was that obese rats were unable to appropriately handle the excess sources of energy, in the form of glucose and dietary fat, which accumulated as a result of overfeeding after surgical ovariectomy. Lean rats stored the excess glucose and dietary fat from overfeeding in liver, fat, muscle and healthy breast tissue, a normal metabolic response to overfeeding. In contrast, the healthy tissues in obese rats failed to increase uptake of glucose and dietary fat, but the breast tumors dramatically increased uptake of g
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. LSUHSC research finding keys to future obesity & related diseases
2. Mouse Study Offers Clues to Obesity-Diabetes Link
3. Use Social Media to Fight Childhood Obesity, Heart Experts Say
4. Scientists discover mechanism that could reduce obesity
5. Obese but happy gene challenges the common perception of link between depression and obesity
6. Study Supports Link Between Obesity, Cavities in Homeless Kids
7. Research strengthens link between obesity and dental health in homeless children
8. Childhood obesity more likely to affect children in poorer neighborhoods
9. Obesity epidemic threatens health of all social groups equally
10. U.S. Med Students May Be Undereducated on Obesity
11. Study Ties Obesity-Related Gene to Weaker Memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... (PRWEB) May 03, 2015 It is not too ... Brain Aneurysm Walk in Memory of Lissa Anne Been in ... organized this great family-friendly event to honor her loving memory. It ... inception. , Just having turned 37, Lissa suffered a ... away on August 24, 2012. This event is designed to serve ...
(Date:5/2/2015)... As one of only 30 Illinois ... and Health Achievement and Recognition Program (SHARP) certification, ... by the Illinois Department of Labor to host this ... SHARP certification by the Occupational Safety and Health Administration’s ... continued to meet or exceed all of the necessary ...
(Date:5/2/2015)... Vancouver fencing company, QS Fencing, has recently announced ... prospective clients related to their questions on railings and gates. ... their decks and patios. While that seems like an easy ... the person rolls up their sleeve to start working. One ... finding a gate that matches it. , Instead of spending ...
(Date:5/2/2015)... 2015 ProText Kinetic 2 is a set ... Cut Pro X. ProText Kinetic 2 features 40 ... Cut Pro X . Easily create interactive text videos ... Studios' ProText Kinetic 2. , Using ProText Kinetic is as ... ProText Kinetic presets in the FCPX timeline. Playback the ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 We are ... The Delray Recovery Center as one of the Top ... known in the addiction treatment field for their ethics ... to innovate and to continue their educational efforts. The ... workplace environment, never forgetting their purpose – to help ...
Breaking Medicine News(10 mins):Health News:Renowned Brain Aneurysm Foundation to Benefit from Arnold, Missouri’s 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2
... say , MONDAY, Oct. 12 (HealthDay News) -- People with ... sense of being able to adapt to changing situations and ... suggests. , And people graced with this genotype showed more ... is probably linked to metabolism of the brain chemical dopamine. ...
... 12 /PRNewswire-FirstCall/ - HTDS www.htdsmedical.com (HTDS) - ... www.slavicabiochem.com is providing an audio recording and ... service. The audio recording a wav file can be ... and the audio recording covers scientific topics and work ...
... The Iowa Committee for Value in Healthcare today issued ... responsible health care that Congress and the Obama administration ... , The committee found that Iowa, nationally recognized for ... value-based reform. Health care providers, purchasers, payers, patient advocates ...
... Mourning, Kidney Care Partners Call Attention to Extended Medicare ... Access to Quality Care , WASHINGTON, Oct. 12 ... advocates, dialysis professionals, care providers and manufacturers working together ... disease and kidney failure - today applauded the Congressional ...
... ... operational capabilities , ... Harrisburg, PA (Vocus) October 12, 2009 -- Gary C. Baker was recently hired to ... Organization, Inc. (KePRO), a leading quality improvement and care management organization. Mr. Baker ...
... October is Sudden Cardiac Arrest Awareness Month, and the ... Quinn with the 2009 Public Leadership Award for his ... prevent sudden cardiac death and improve cardiovascular health. The ... Saturday, October 10, 2009, at the Hyatt Regency O,Hare ...
Cached Medicine News:Health News:Gene Mutation May Speed Learning 2Health News:Slavica Bio Chem (HTDS) Subsidiary Medical Team Message 2Health News:Slavica Bio Chem (HTDS) Subsidiary Medical Team Message 3Health News:Slavica Bio Chem (HTDS) Subsidiary Medical Team Message 4Health News:Iowa Committee Makes Recommendations to Increase Value in Health Care 2Health News:Iowa Committee Makes Recommendations to Increase Value in Health Care 3Health News:Iowa Committee Makes Recommendations to Increase Value in Health Care 4Health News:Iowa Committee Makes Recommendations to Increase Value in Health Care 5Health News:Kidney Care Community Commends Congressional Black Caucus for Naming Expansion of Medicare Provisions for Kidney Failure Patients as Top Priority 2Health News:Kidney Care Community Commends Congressional Black Caucus for Naming Expansion of Medicare Provisions for Kidney Failure Patients as Top Priority 3Health News:Gary C. Baker Named KePRO Chief Financial Officer 2Health News:Gary C. Baker Named KePRO Chief Financial Officer 3Health News:Sudden Cardiac Arrest Association Honors Illinois Governor Pat Quinn for Legislative Efforts to Increase Survivability of Sudden Cardiac Arrest 2
(Date:5/1/2015)... Calif., May 1, 2015 Pharmacyclics, Inc. (the ... for the quarter ended March 31, 2015, as well ... AbbVie Inc., no conference call will be held. ... quarter ended March 31, 2015 increased to $206 million ... 2014. , Worldwide IMBRUVICA ® (ibrutinib) net ...
(Date:5/1/2015)... -- Semler Scientific, Inc. (Nasdaq: SMLR ), an ... markets products that assist healthcare providers in monitoring patients ... the first quarter ended March 31, 2015. ... continued progress with year over year growth of 44% ... said Doug Murphy-Chutorian , M.D., chief executive officer ...
(Date:5/1/2015)... May 1, 2015  AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ... and commercialization of innovative therapies for the treatment of ... E. Morris , chief financial officer  will be participating ... are as follows: Mizuho Third Annual Healthcare ... Omni Berkshire Place, New York ...
Breaking Medicine Technology:Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 2Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 3Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 5Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 6Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 7Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 8Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 9Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 10Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 11Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 12Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 13Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 14Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 15Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 16Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 17Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 18Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 19Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 20Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 21Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 22Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 23Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 24Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 25Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 26Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 27Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 28Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 29Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 30Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 31Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 32Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 33Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4
... 21, 2012 As communities in the United States gather ... Pharma, LLC,s SyNAPSe® clinical trial reaches an important enrollment milestone. ... in March to raise awareness for the need for better ... than 75 clinical trials in the past 20 years, no ...
... Faruqi, LLP, a leading national securities law firm, ... Inc. ("ZELTIQ" or the "Company") (NASDAQ: ZLTQ).    ... Faruqi & Faruqi is investigating allegations that ZELTIQ ... information about the delayed sale of Company products ...
Cached Medicine Technology:BHR Pharma's SyNAPSe® Trial Reaches Important Enrollment Milestone on Brain Injury Awareness Day 2BHR Pharma's SyNAPSe® Trial Reaches Important Enrollment Milestone on Brain Injury Awareness Day 3Faruqi & Faruqi, LLP Announces Investigation of ZELTIQ Aesthetics, Inc. 2
... tiny, water-resistant monitor captures the data you ... ,Requiring only five electrodes, the DigiTrak ... the entire patient test, which can be ... AA battery. Three channels of ECG recording ...
... biograph 6 offers the ultimate ... diagnosis and treatment in oncology, ... high-quality PET/CT whole body scans ... Our comprehensive suite of clinical ...
... Lunar DPX Duo is a SmartBeam platform ... get measurements of the two most clinical ... seconds, and at a low radiation dose., ... based on Windows, optimizes productivity and ensures ...
... ScImage's PICOMEnterprise is a web-enabled ... custom reporting and custom workflow integration. ... captures, stores, distributes and archives images, ... any DICOM and many non-DICOM devices ...
Medicine Products: