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Obesity and metabolism: Weight gain and the growing risk of cancer
Date:12/7/2007

PHILADELPHIA During this holiday season with its tempting bounty of edible delights, new research calls attention to the role of the expanding American waistline in health and medicine.

Today, researchers at the American Association for Cancer Researchs Sixth Annual International Conference on Frontiers in Cancer Prevention Research, being held from December 5 to 8 in Philadelphia, Pennsylvania, present some of the latest research linking obesity, diabetes and metabolism to cancer risk. Their findings link weight gain and diabetes to a variety of cancers affecting both men and women, including breast, prostate and colorectal cancer


Diabetes and hyper-insulinemia as predictors of colorectal cancer risk in a prospective cohort of women. Abstract no. B93:

Women with diabetes are 1.5 times more likely to develop colorectal cancer than those who do not have the metabolic disorder, according to researchers at the University of Minnesota. The findings, they say, add to the complex body of evidence linking diet and colorectal cancer and also provide new evidence that furthers our understanding of the role of insulin in cancer promotion.

Colorectal cancer and type II diabetes share a number of common factors, including obesity, so it is interesting to see the direct line between these two conditions, said Andrew Flood, Ph.D., assistant professor in the Division of Epidemiology and Community Health at the University of Minnesota School of Public Health and the University of Minnesota Cancer Center In general, the idea is that if elevated insulin levels create a biochemical environment conducive to cancer growth, it provides one mechanism by which diet and lifestyle can really influence cancer risk.

With funding from the National Cancer Institute, Flood and his colleagues examined data from a massive screening study called the Breast Cancer Detection Demonstration Project, initiated at 29 centers throughout
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Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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