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Obesity and diabetes have adverse effects on cancer outcomes
Date:3/20/2014

and national guidelines.

The vast majority of the patients in this study received chemotherapy doses capped at a body surface area (BSA) of 2.0m, which is often the limit when calculating doses. "Obese patients may have a BSA of more 2.0m, but the chemotherapy dose they receive will not reflect this. It is a very common practice in these patients for fear of overdosing, but of course it means that they will often receive a relatively lower quantity of chemotherapy," Dr Fontanella will say. "In my opinion, a deeper understanding of chemotherapy metabolism and distribution in patients with high BMI and with increased adipose tissue is needed."

"We already know that obese hormone receptor-positive tumour patients respond less well to aromatase inhibitors as adjuvant treatment, and this underlines a key role of higher aromatase activity in patients with increased adipose tissue." Aromatase is an enzyme that synthesises oestrogen, and blocking it is important in cancers where oestrogen encourages tumours to grow.

Final analysis of outcomes from the two groups in the joint study showed a significant decrease in survival without the cancer spreading (metastasising) distant disease-free survival (DDFS) or the cancer recurring distant relapse-free survival (DRFS) in patients with increased BMI in all tumour types, apart from those with HER2-positive tumours.

"The exception in this group can probably be explained by the impressive impact of anti-HER2 treatment," Dr Fontanella will say. "Given the significant proportion of the world's population with a BMI higher than recommended for good health, it is vitally important that we find a way to treat overweight and obese cancer patients that combines maximum efficacy with the avoidance of unnecessary side-effects."

In a second study, Dr Fontanella and colleagues investigated the incidence of Type 2 (adult onset) diabetes in patients with early breast cancer at the time of diagnosis, as well as its effec
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Contact: Mary Rice
mary.rice@riceconseil.eu
ECCO-the European CanCer Organisation
Source:Eurekalert

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