Navigation Links
Obesity Weakens Immune Response
Date:12/12/2007

Study found fat mice had harder time fighting gum disease

WEDNESDAY, Dec. 12 (HealthDay News) -- Obese people find it harder to fight infections, and a weakened immune response may be to blame, suggests a new study from Boston University researchers.

In experiments with mice infected with the bacteria Porphyromonas gingivalis, obese mice had less ability to battle gum infection than their normal-weight counterparts, according to the report in this week's early online edition of the Proceedings of the National Academy of Sciences.

"For years, we have had difficulty understanding why obese people have difficulty clearing an infection," said lead researcher Dr. Salomon Amar, associate dean for research at the university's School of Dental Medicine.

"Now we understand that dysfunction in some of the mechanisms, as a result of the obesity, explain difficulty in clearing the infection and also the difficulty in wound healing," Amar said.

In the study, Amar's team tied silk threads infected with the bacteria around the molars of obese and normal-weight mice. They then compared the animals' responses to infection, by measuring both the amount of bone loss and the growth of the bacteria around their teeth.

The researchers found that the obese mice had a compromised immune response to the bacteria, which made the animals more susceptible to the infection.

Amar's group also looked at the animals' white blood cells, which are the main line of defense against infection. The white cells of obese mice had lower levels of an important signaling molecule, and some of the genes that fight inflammation were altered, the researchers found.

Why obesity has this effect isn't clear, but the researchers think it may involve a signaling pathway that controls a protein called NF-kB. Alterations in this protein may be caused by constant exposure to food, Amar explained. "At some point, the body doesn't respond properly to infection," he said.

The same mechanism is at work in humans, Amar added. In fact, studies in obese people have shown they are more likely to have gum disease than non-obese people. The disease is caused by bacteria, which causes inflammation and destruction of the bone underlying teeth.

Amar thinks that obese people need to be treated differently to help them fight infections. "We need to be more aggressive in the use of targeted antibiotics in infections among obese people," he said. "Also, we need to boost the immune response."

One expert agreed the finding sheds light on the connection between obesity and infection.

"Very interesting paper," said Dr. Sara G. Grossi, a senior research scientist at the Brody School of Medicine of East Carolina University. "This is a study that needed to be done, with very interesting results and implications for both obesity and periodontal disease -- two diseases that are easier to prevent than to treat."

More information

For more about gum disease, visit the American Academy of Periodontology.



SOURCES: Salomon Amar, D.D.S., Ph.D., professor and associate dean, research, School of Dental Medicine, Boston University Medical Center; Sara G. Grossi, D.D.S., Brody School of Medicine, East Carolina University, Greenville, N.C.; Dec. 12, 2007, Proceedings of the National Academy of Sciences online


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. This October, the American Physical Therapy Associations National Physical Therapy Month to Focus on Nations Obesity Epidemic
10. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
11. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Obesity Weakens Immune Response
(Date:7/20/2017)... ... July 20, 2017 , ... Acute myeloid ... cancer that progresses rapidly without treatment. Newly diagnosed patients face intense chemotherapy regimens ... reoccurrence and relapse. With such a challenging diagnosis that requires immediate action, ...
(Date:7/20/2017)... New York (PRWEB) , ... July 20, 2017 ... ... has developed a telemedicine platform, in which their iMedSecure™ comes included with each ... both share encrypted live images to remote participants for real-time collaboration and immediate ...
(Date:7/20/2017)... ... July 20, 2017 , ... Girl Up Campaign ... and Senate legislation in support of providing girls access to education in refugee ... 2408, the “Protecting Girls’ Access to Education in Vulnerable Settings Act.” Yesterday, companion ...
(Date:7/20/2017)... Orange, NJ (PRWEB) , ... July 20, 2017 , ... ... people wondering if herniated and bulging discs are the same thing. But it’s crucial ... in order to seek proper treatment, according to Kaixuan Liu, MD, PhD, founder and ...
(Date:7/20/2017)... Charlotte, NC (PRWEB) , ... July 20, 2017 , ... ... announces the latest innovation to their product line: the AVE 2 birthing bed. , ... 2 helps bring a new level of comfort and efficiency to every phase of ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... development of oral drug delivery systems, announced today that ... to schedule an End-of-Phase II meeting with Oramed for ... insulin capsule ORMD-0801 in the treatment of type 2 ... endpoints by indicating a statistically significant lowering of glucose ...
(Date:7/10/2017)...  The tenth annual BioPharm America™ will ... at the Sheraton Boston Hotel, September 26–27. The event ... decision makers and innovative biotech startup companies. The event ... two impactful days. BioPharm America is now part of ... opportunities with 4,500+ life science industry influencers participating in ...
(Date:7/5/2017)... , July 5, 2017 ... www.oramed.com ), a clinical-stage pharmaceutical company focused ... that it has received approval from the Israel Securities Authority ... Exchange (TASE). Oramed common stock will commence trading on the ... on the current market capitalization of the Company, it is ...
Breaking Medicine Technology: