Navigation Links
Obesity-Related Inflammation Boosts Heart Risks

Blood chemicals in overweight participants were key predictors of organ failure, study says

TUESDAY, May 6 (HealthDay News) -- Obesity causes prolonged inflammation of heart tissue that in turn boosts heart failure risk, according to a U.S. study of almost 7,000 people.

The latest findings from the Multiethnic Study of Atherosclerosis (MESA) are believed to provide the first large scale of evidence of such a link and give the estimated 72 million obese American adults another reason to change their lifestyle.

"The biological effects of obesity on the heart are profound. Even if obese people feel otherwise healthy, there are measurable and early chemical signs of damage to their heart, beyond the well-known implications for diabetes and high blood pressure," senior study investigator Dr. Joao Lima, a professor of medicine and radiology at the Johns Hopkins University School of Medicine and its Heart Institute, said in a prepared statement.

There is "now even more reason for (obese people) to lose weight, increase their physical activity and improve their eating habits," Lima said.

He and his colleagues tracked the development of heart failure in an ethnically diverse group of nearly 7,000 people, ages 45 to 84, who enrolled in the MESA study, starting in 2000. Of the 79 participants who've developed congestive heart failure so far, 35 (44 percent) were physically obese (body mass index of 30 or greater).

On average, obese participants were found to have higher blood levels of key immune system proteins involved in inflammation (interleukin 6, C-reactive protein, and fibrinogen) than non-obese participants. A near doubling of average interleukin 6 levels alone was associated with an 84 percent increased risk of heart failure.

"Our results showed that when the effects of other known disease risk factors -- including race, age, sex, diabetes, high blood pressure, smoking, family history and blood cholesterol levels -- were statistically removed from the analysis, inflammatory chemicals in the blood of obese participants stood out as key predictors of who got heart failure," Lima said.

He added that doctors "need to monitor their obese patients for early signs of inflammation in the heart and to use this information in determining how aggressively to treat the condition."

Lima and colleagues also found a link between inflammation and metabolic syndrome, which doubles a person's chances of developing heart failure. Metabolic syndrome is a collection of risk factors -- obesity, high blood pressure, elevated blood glucose levels, excess abdominal fat, and abnormal cholesterol levels -- that increase the risk of heart disease and diabetes.

The study was published in the May 6 issue of the Journal of the American College of Cardiology. The MESA study was expected to continue tracking patients through 2012.

More information

The American Heart Association has more about heart failure.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, May 1, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cyberonics Licenses Obesity-Related Patents
2. Pathway links inflammation, angiogenesis and breast cancer
3. New insights into inflammation in osteoarthritis
4. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
5. Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
6. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
7. Inflammation Cant Explain Depressions Link to Heart Disease
8. UC Davis researchers discover novel pathway to increased inflammation in diabetes patients
9. Exercise may play role in reducing inflammation in damaged skin tissue
10. Researchers develop powerful tool to study the genetics of inflammation
11. Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... The successful filing of an Investigational New Drug ... so important to this key industry segment, Regis Technologies has decided to sponsor and ... 4th at 11am EST. , Federal law does not allow new drugs to cross ...
(Date:11/30/2015)... ... November 30, 2015 , ... SIMmersion’s ... importance to the medical schools of the future. To reach an audience of ... the 2015 ChangeMedEd conference in Chicago, organized by the American Medical Association. ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... announce their strategic partnership at the Radiological Society of North America (RSNA) ... Winscribe, global providers of cutting-edge dictation and speech-enabled documentation software, announced their ...
(Date:11/30/2015)... ... November 30, 2015 , ... Bayco Products, Inc today announced the introduction of three Nightstick® brand ... choice of three different colors; red ( NSP-1632 ), yellow ( NSP-1634 ) and blue ... hours in constant-on mode, or 27 hours in blinking strobe mode using a fresh set ...
(Date:11/29/2015)... ... November 30, 2015 , ... The Cyber Monday deal is a deep 40% or more discount ... to get gifts for the skin care lover in your circle. Each Christmas, Sublime ... This year, the 3 serums are staples: Collagen, Retinol and Hyaluronic Serums. , Stocking stuffers ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Japanese therapeutic drug monitoring market, ...
(Date:11/26/2015)... 2015 ) ... "2016 Future Horizons and Growth Strategies in ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> ) has announced ... Horizons and Growth Strategies in the German ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
Breaking Medicine Technology: