Navigation Links
Obesity May Worsen Impact of Asthma
Date:5/1/2008

Heaviest lose ability to inhale as deeply or exhale as fully as normal weight individuals

THURSDAY, May 1 (HealthDay News) -- A study of women with a wide range of body-mass indexes (BMIs) found that obesity may worsen the impact of asthma and also mask its severity in standard tests.

"We have demonstrated significant differences in the changes in respiratory function that occur with asthmatic bronchoconstriction in relation to obesity," principal investigator Dr. D. Robin Taylor, of the University of Otago in New Zealand, said in a prepared statement.

The study also found that simple spirometry couldn't determine the level of pulmonary dysfunction in obese people with asthma.

The findings were published in the first issue for May of the American Journal of Respiratory and Critical Care Medicine. It's the first prospective study to find a significant comparative difference between obese and non-obese people in how the lungs and airways respond to a simulated asthma attack.

The researchers said it establishes a direct link between obesity and the development of dynamic hyperinflation -- air breathed into the lungs can't be expelled. This often occurs with acute asthma, but is more frequent in obese people.

The study included 30 asthmatic women who were divided into three groups based on their BMI: normal weight, overweight and obese. All the women breathed nebulized methacholine to induce an asthma-like attack and were then assessed for changes in lung function, including functional residual capacity (FRC -- how much air remained in the lungs after exhalation) and inspiratory capacity (IC -- how much air could be inhaled on the next breath).

"After the methacholine challenge, the amount of bronchoconstriction was identical for each of the three groups, but the changes in FRC and IC were greatest in the obese group. This indicated to us that greater dynamic hyperinflation was occurring among obese individuals," Taylor said.

The greater a woman's BMI, the higher her FRC and the lower her IC.

"This means that among women with greater BMI, an asthma-like episode has the potential to cause greater breathing difficulties than in non-obese women. The greater dynamic hyperinflation means that obese individuals lose the ability to inhale as deeply or exhale as fully as normal weight individuals," Taylor said.

The findings suggest fundamental differences in the way that obese people with asthma may experience shortness of breath.

"We know that asthma in obese subjects is more likely to persist and is more likely to be perceived to be severe. These individuals often require more treatment to achieve asthma control. Our study provides an insight into why this might be happening -- the same asthma trigger produces a greater effect in obese individuals," Taylor said.

More research is needed to "confirm that the differences in dynamic hyperinflation between obese and non-obese asthmatics are sufficient to explain the differences in symptoms between the two groups. Our study was not large enough to do this," Taylor said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about asthma.



-- Robert Preidt



SOURCE: American Thoracic Society, news release, May 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Obesity worsens impact of asthma
2. ENDO 08: Latest news on hormones, steroids, obesity, diabetes and more
3. U.S. Surgeon General Launches New Effort to Address Childhood Obesity
4. Fighting Childhood Obesity with Tools and Teaching
5. Cancer survivors have low levels of physical activity and high levels of obesity
6. Obesity, inactivity as common among cancer survivors as rest of Canadians, study shows
7. Metabolic Syndrome Triggered by Overeating, Not Obesity
8. Study suggests too much screen time and not enough physical activity may lead to childhood obesity
9. Susan Powter The Politics of Stupid: The Cure for Obesity
10. Video: U.S. Olympic Hopefuls Featured in National Campaign to Combat Childhood Obesity
11. New study in JCSM finds that obesity can predict upper airway obstruction amongst children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Obesity May Worsen Impact of Asthma
(Date:2/27/2017)... ... February 27, 2017 , ... Texas based retail electric company ... Power's RCE (Residential Customer Equivalent) count exceeds 150,000. , Discount Power ... customers and 2,250 RCEs at the time of acquisition. In the three years ...
(Date:2/27/2017)... , ... February 27, 2017 , ... New Jersey ranks ... among all types and genders. And the need for advanced services is growing. ... its top-rated cancer care program, in collaboration with their non-profit partners in their fight ...
(Date:2/26/2017)... San Mateo, CA (PRWEB) , ... February 26, 2017 , ... ... Bay Area cities as diverse as Millbrae, Belmont, and Palo Alto, is proud to ... San Mateo. Many Bay Area consumers look for home care close to home, and ...
(Date:2/26/2017)... VA (PRWEB) , ... February 26, 2017 , ... ODH, ... Managed Care Summit, February 27-28 at the Sheraton Pentagon City Hotel in Arlington, VA. ... with PerformCARE to use behavioral health analytics to improve Medicaid population health management. , ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... newly designed TaskMate Go. Core benefits and advantages built into the home office ... stylish, functional look and feel. Ability to gain the benefits embedded in the ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... Inc. (NYSE: HYH ) today reported fourth quarter ... related key planning assumptions. Executive Summary 2016 fourth ... compared to the prior year. Net income ... net income of $15 million in the fourth quarter of ... to adjusted net income of $27 million in the prior ...
(Date:2/27/2017)... Texas , Feb. 27, 2017  International Biophysics Corporation, ... Texas , today announced a 34% revenue growth in ... 53% increase in unit sales.  This growth was fueled by ... in addition to the expansion of its global sales ... Jr., International Biophysics, CEO, "As we enter our 25 th ...
(Date:2/27/2017)... (NASDAQ: IPXL ) today announced that it plans to participate ... James and Associates, 38 th Annual Institutional Investors Conference at ... Cowen and Company 37 th Annual ... Boston, MA. Barclays Global Healthcare ... FL. Individuals may listen to the ...
Breaking Medicine Technology: