Navigation Links
Obesity Linked to Ovarian Cancer
Date:1/5/2009

Excess estrogen may contribute to malignancy, study suggests

MONDAY, Jan. 5 (HealthDay News) -- Obese postmenopausal women who have never used hormone replacement therapy may face an increased risk of ovarian cancer, compared to normal-weight women, a new study suggests.

Interestingly, obese women who have used hormone replacement therapy (HRT) for symptoms of menopause may not face increased risk for this type of malignancy.

The study findings are published in the Feb. 15 issue of the journal Cancer.

The take-home message is a familiar one, experts said: Maintain a healthy body weight.

"This is another, very fine epidemiologic study that shows a relationship between obesity and female-related cancers," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La. "The two leading causes of cancer in the western world today are tobacco and obesity. We've made enormous progress with tobacco-related malignancies -- it's really stunning. The next wave is obesity-related illness."

Added Dr. Elizabeth A. Poynor, a gynecologic oncologist at Lenox Hill Hospital in New York City, "This is yet another health risk that we can talk about with women who are overweight, and yet another reason to lose weight."

Ovarian cancer is the fifth leading cancer killer of U.S. women and the leading killer among gynecologic malignancies. Only about 37 percent of women with this diagnosis will survive beyond five years, according to background information in the study.

Women who've had children and who've used oral contraceptives appear to have a decreased risk of the disease.

A family history of ovarian cancer along with HRT use is known to contribute to the risk, and there has been some evidence that excess body weight also ups the risk.

For the new study, investigators from the U.S. National Cancer Institute followed almost 95,000 U.S. women, aged 50 to 71, for an average of seven years.

Overall, obese women -- those with a body mass index (BMI) or 30 or above -- had a 26 percent higher chance of developing ovarian cancer than women of normal weight, a figure the researchers said was not statistically significant.

However, the picture was somewhat different among subgroups of women. Obese women who had never used hormone therapy had an 80 percent higher risk of developing ovarian cancer, compared with their normal-weight counterparts. There appeared to be no relationship between BMI and ovarian cancer among women who had used hormone therapy for menopausal symptoms.

Obese women without a family history of the disease had a 36 percent higher risk of developing ovarian cancer, although there was no heightened risk in obese women who did have a family history.

According to the study authors, the findings indicate that obesity may increase ovarian cancer risk through hormonal effects. Specifically, excess fat increases production of estrogen, which may spur the growth of ovarian cancer.

But the picture is likely much more complicated than that, said Dr. Michael A. Bookman, vice president for ambulatory care and clinical research at Fox Chase Cancer Center in Philadelphia.

Overall, obese women in the study did not have a notably higher risk for ovarian cancer. The increased risk was only seen in a subgroup of the women, he noted.

"When you do a subset analysis, there's always a risk," Bookman said. "They wave their hands and think maybe this is because estrogen is bad for you, but there are a lot of other things obesity does than create endogenous estrogen, like other growth factors.

"It's interesting that, in women who were exposed to menopausal hormones, there was some evidence that [hormones] actually protected them," he added. "It's, at best, a modest effect and not nearly as strong as the data with endometrial cancer. I'm not a fan of obesity, but I think, in this particular analysis, it's a pretty modest effect. It would be much more convincing if it were significant for the entire population."

Study lead author Dr. Michael Leitzmann, of the National Cancer Institute, said one "possible reason for the observation that obesity might lead to increased ovarian cancer risk in women who have not used HRT versus women who have is that exogenous estrogens supplied by menopausal hormones fail to add further to the high background levels of endogenous estrogens among obese women."

More information

The U.S. National Cancer Institute has more on ovarian cancer.



SOURCES: Jay Brooks, M.D., chairman of hematology/oncology, Ochsner Clinic Foundation, Baton Rouge, La.; Elizabeth A. Poynor, M.D., Ph.D., gynecologic oncologist, Lenox Hill Hospital, New York City; Michael A. Bookman, M.D., vice president for ambulatory care and clinical research, Fox Chase Cancer Center, Philadelphia; Michael F. Leitzmann, M.D., DrPH, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, U.S. National Cancer Institute, Bethesda, Md.; Feb. 15, 2009, Cancer


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study links obesity to elevated risk of ovarian cancer
2. Minimizing obesitys impact on ovarian cancer survival
3. Childhood Obesity May Cause Thyroid Problems
4. Obesity increases lymphedema risk for breast cancer survivors
5. Study Finds Molecular Link Between Obesity, Hypertension
6. Obesity-Related Hormone Tied to Psoriasis
7. Genetic Variants Tied to Obesity
8. Health Care Service Corporation Finds Success With Innovative Program Targeting Obesity Epidemic
9. Fast Heart Rate Warns of Obesity, Diabetes
10. Obesity among states low-income teens nearly triple that of more affluent peers
11. Obesity is a Family Affair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... American ... chief medical officer of Blue Horizon International (BHI), Brian Mehling, M.D., spoke at ... held during May 5-6, 2016 in Chicago, IL, USA. Dr. Mehling’s presentation was ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... and products recently hosted the first PowerWave Instructor Certification Course in Stoughton, Massachusetts. ... a group of fitness professional through the 8 hour interactive course to qualify ...
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during ... Water Life Science® and international water advocate, was honored by Ashram, Inc. as the ... ancient Egypt who knelt on the banks of the Nile to fill their red ...
(Date:5/26/2016)... ... May 26, 2016 , ... Workrite ... sales leadership and to further develop their rapidly expanding portfolio of customer and ... with a concentration in Marketing and an M.B.A. with concentration in management from ...
(Date:5/26/2016)... ... , ... May 2016 – Lips may be a central feature on our ... numbers of clients now ask about lip plumping and primping techniques and want tips ... Advanced Dermatology P.C. , The trend is a national one, with 2.4 ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... CHESTERFIELD, Va. , May 25, 2016 /PRNewswire/ ... next-generation sequencing test for wounds and infections. This ... ALL parasites, and select viruses. The test requires ... area. David G. Bostwick ... molecular testing to facilitate wound healing: "We are ...
(Date:5/25/2016)... 2016 ReportsnReports.com adds "Chronic ... that provides an overview on therapeutic pipeline of ... stages, therapeutics assessment by drug target, mechanism of ... type, along with latest updates, and featured news ... involved in the therapeutic development for Chronic Cough ...
(Date:5/24/2016)...   , Study met ... bowel cleansing and superiority in , ... of the ascending colon   ... Norgine B.V. today announced new positive data from the phase ... preparation) versus standard 2 litre PEG with ascorbate. The study met ...
Breaking Medicine Technology: