Navigation Links
Obesity Drug Shows Mixed Success Against Atherosclerosis
Date:4/1/2008

Hope is that Acomplia might help fight coronary disease

TUESDAY, April 1 (HealthDay News) -- The weight-loss drug Acomplia may or may not help slow atherosclerosis, a buildup of arterial plaque that's connected with carrying too much weight.

A new trial did not find any evidence that the drug actually slowed disease progression, although it did show a decrease in one measure of plaque build-up in arteries.

Acomplia also showed a high rate of psychiatric side effects, notably depression and anxiety, the study found.

Still, Dr. Suzanne Steinbaum, director of Women and Heart Disease at Lenox Hill Hospital in New York City, who was not involved with the study, said: "I think it's important for us to understand that this wasn't a negative trial. It's very important that we look at this more closely. What decrease in blood pressure and cholesterol as parameters are needed, or really how much decrease in obesity is needed for us to see a change in atherosclerosis volume? It might pan out to show something beneficial. We just don't know."

The findings, from researchers at the Cleveland Clinic, were published April 2 in the Journal of the American Medical Association and were released early Tuesday to coincide with a presentation at the American College of Cardiology annual meeting, in Chicago. The study was funded by Sanofi Aventis, which makes Acomplia.

Data on a second anti-obesity drug, taranabant, also presented at the conference, also showed a high rate of psychiatric problems, although the medication did show some promise helping patients lose weight.

In the United States, two-thirds of adults are overweight, and more than one-third are obese. People with weight concentrated in their midsection have a higher risk of type 2 diabetes, high blood pressure and other risk factors for atherosclerotic cardiovascular disease or disease related to the build-up of plaque in the arteries.

Not for lack of effort, researchers have yet to happen on a "magic" treatment for obesity and its attendant problems.

One drug that has shown some promise, Acomplia (rimonabant), has been approved for use in Europe but not in the United States. Last June, the U.S. Food and Drug Administration did not recommend approval of the drug, pending more information on psychiatric side effects.

The drug works by inhibiting the cannabinoid type 1(CB1) receptors, which are involved in regulating food ingestion.

For the new study, 839 patients at 112 centers in Australia, Europe and North America were randomly selected to receive either Acomplia or a placebo. All participants, who also had coronary disease, received dietary counseling as well.

Coronary intravascular ultrasonography (IVUS) at the end of 18 months revealed a 0.25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0.51 percent in the placebo group. And change in normalized total atheroma volume (TAV) decreased in the Acomplia group but increased in the placebo group. PAV and TAV are basically two ways to measure how clogged an artery is.

Those taking Acomplia also saw other benefits: They lost more weight (9.5 pounds versus 1.1 pounds in the placebo group); their waist circumference went down more (1.77 inches versus 0.39 inches); their HDL or "good" cholesterol increased more (22.4 percent versus 6.9 percent) and triglyceride levels went down further (20.5 percent versus 6.2 percent). But LDL or "bad" cholesterol levels and blood pressure stayed about the same in both groups.

More worrisome, 43.4 percent of those in the Acomplia group experienced psychiatric problems, most notably anxiety and depression, compared to 28.4 percent in the placebo group.

More information

The U.S. Centers for Disease Control and Prevention has more on overweight and obesity.



SOURCES: Suzanne Steinbaum, D.O., director, Women and Heart Disease, Lenox Hill Hospital, New York City; April 2, 2008, Journal of the American Medical Association; April 1, 2008, presentation, American College of Cardiology annual meeting, Chicago


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Normal weight obesity: An emerging risk factor for heart and metabolic problems
2. California Association of Health Plans & California Medical Association Foundation Team Up to Combat Obesity
3. EnergyNow! Announces New Grant Funding to Combat Childhood Obesity
4. U.S. Surgeon General to Keynote Special Childhood Obesity Prevention Presentation in Philadelphia
5. Drug Treatment Market For Obesity Will Increase More Than Five-Fold, Reaching $2.7 Billion in 2016
6. Soccer Legend Tab Ramos, Subway(R) Restaurants Team Up To Fight Juvenile Obesity Among Latinos
7. Obesity may keep some women from getting screened for breast, cervical cancer
8. Blue Cross and Blue Shield of Illinois Announces Campaign to Address Childhood Obesity
9. Acting U.S. Surgeon General to Speak to Society for Adolescent Medicine on Prevention of Adolescent Overweight and Obesity
10. Arena Pharmaceuticals Lorcaserin for Obesity Passes Major Safety Milestone
11. Obesity Linked to Poor Prognosis for Some Breast Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
Breaking Medicine Technology: