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Obesity Doesn't Always Guarantee Heart Disease
Date:6/21/2010

Dr. Gregg C. Fonarow, director of the Ahmanson-UCLA Cardiomyopathy Center at the University of California, Los Angeles, said that "while this study did not find increased risk associated with obesity if no metabolic abnormalities were present, it is important to note that other studies with longer-term follow-up have shown there is an increased risk of cardiovascular events in these individuals."

"The balance of evidence suggests that, over the long-term, obesity imparts higher cardiovascular risk, even if metabolic abnormalities are not present at baseline," he said.

A researcher specializing in diabetes and metabolic syndrome also thinks the follow-up period in the study is too short to draw firm conclusions about whether certain obese people are protected from heart disease.

Dr. Tae-Hwa Chun, an assistant professor of internal medicine at the University of Michigan, said that "clearly we need to know why some overweight and obese individuals are protected from metabolic deterioration and increased cardiovascular risk."

This study suggests that identifying the genetic and molecular mechanism that underlies the deadly link between obesity and cardiovascular risk, which is selectively found in a subset of individuals, is more important than simply measuring body-mass index, Chun said.

"There is a caveat in this study, however, as the cardiovascular event rate is so low in the short follow-up period, the study may not possess enough statistical power to detect a potential difference in cardiovascular risk," he said.

More information

For more information on obesity and heart disease visit the American Heart Association.



SOURCES: Andre van Beek, M.D., Ph.D., of University Medical Center Groningen, Groningen, The Netherlands; Gregg C. Fonarow, M.D., professor, me
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