Navigation Links
Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer
Date:2/26/2013

PHILADELPHIA An increasing body mass index was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"We know that exercise and avoiding obesity decrease colorectal cancer risk, but little is known about why," said Shuji Ogino, M.D., Ph.D., associate professor of pathology at Dana-Farber Cancer Institute and associate professor in the Department of Epidemiology at Harvard School of Public Health in Boston, Mass. "In this study, we used a biomarker named CTNNB1, which is a molecule implicated in cancer and obesity, to divide patients into two groups, CTNNB1-positive and CTNNB1-negative."

Ogino and colleagues used data from more than 100,000 women from the Nurses' Health Study and more than 45,000 men in the Health Professionals Study to examine whether there was an association between body mass index (BMI) or exercise activity and colorectal cancer risk according to CTNNB1 expression status.

Among the study population, 2,263 individuals were diagnosed with colorectal cancer during follow-up. Tumor CTNNB1 expression data were available for 861 of these individuals, and 54 percent of these tumors were negative for CTNNB1 and 46 percent positive for the biomarker.

Increasing BMI by a 5.0 kg/m2 increment was associated with a 34 percent higher risk for CTNNB1-negative cancer, but was not associated with CTNNB1-positive cancer. In contrast, increasing physical activity level was associated with a significantly lower risk for CTNNB1-negative cancer. It was not associated with CTNNB1-positive cancer.

"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Ogino said. "If physicians a
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Outdoor Fast-Food Ads Linked to Obesity, Study Suggests
2. Obesity, excess weight gain during pregnancy linked to heavier babies in African-American women
3. Researchers identify role for protein linked to obesity, type 2 diabetes
4. Use Social Media to Fight Childhood Obesity, Heart Experts Say
5. Study Supports Link Between Obesity, Cavities in Homeless Kids
6. In obesity, a micro-RNA causes metabolic problems
7. What babies eat after birth likely determines lifetime risk of obesity, rat study suggests
8. Obesity, larger waist size associated with better outcomes in heart failure patients
9. Wayne State University researcher seeks to understand link between obesity, flu severity
10. Obesity, A Contributing Cause Of Arthritis Of The Knee, Is Now Being Treated With Regenerative Medicine At The Center For Regenerative Medicine
11. Peaches, plums, nectarines give obesity, diabetes slim chance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... ... Skimmer Helper, a household invention that cleans pools efficiently - minus the backbreaking ... Scott Cooper, CEO and Creative Director of World Patent Marketing. "It is a ...
(Date:7/28/2015)... Florida (PRWEB) , ... July 28, 2015 , ... ... of patented products, announces Shelled Out, a new household invention that makes shelling ... earn $253.4 billion by 2020,” says Scott Cooper, CEO and Creative Director of ...
(Date:7/28/2015)... ... July 28, 2015 , ... Darryl ... as volunteers celebrate the 14th year of raising money for the Darryl Worley ... Savannah for this year’s main concert Saturday, Oct. 3. , This year’s concert ...
(Date:7/28/2015)... ... July 28, 2015 , ... Morristown Medical Center, part of Atlantic ... of the first five hospitals in the nation, to implant the newly approved CoreValve® ... 23, and all are in good condition. , The CoreValve® Evolut® R System was ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... announced today that the company is in full support of National Immunization Awareness ... sometimes deadly diseases. To stay protected against serious illnesses like the flu, measles, ...
Breaking Medicine News(10 mins):Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 2Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 3Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 4Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 5Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 2Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 3Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 4Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 5Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 2Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 3Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 2Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 3
... have stated that Biotechnology will provide the most effective ... genome project, and developments in understanding of diseases ... and vaccines that will protect society against bioterrorist attacks ... of the American Association for the Advancement of Science ...
... snapshots could help identify with precision people at high ... say their technique is cheap enough to be used ... by brain cell death due to bleeding from damaged ... in the Asia alone. , , Retinal ...
... vitamin D, increases bone mass and lowers the risk ... is known to stimulate new bone formation, but concerns ... elderly, according to Dr. Craig D. Rubin from University ... who contributed to the research.// There is no FDA-approved ...
... lot of fruit and vegetables have healthier lungs than those ... journal Thorax, analysed data taken in the 1980s. ,It found ... people with a high intake of two particular vitamins - ... also associated with improved lung health.// ,Scientists believe ...
... normal role for a gene that causes two rare hair-loss ... were finding it diificult to treat ordinary baldness. So far, ... a direct link between the hairless gene and typical baldness. ... gene causes the rare hair-loss disorders when it malfunctions. ...
... dermatologists, there is a new high-tech way of smoothing out ... an inevitable sign of ageing, especially if you've spent time ... their limitations, and surgery is expensive so you might feel ... Robert Weiss of Cleavland University//, there are now a number ...
Cached Medicine News:Health News:Biotechnology on the lead 2
(Date:7/28/2015)... -- A German Diabetes Center clinical study found that ... enriches human gut microbiota and modifies gut production of ... daily administration of Nutraceutix,s L. reuteri strain ... tract ® delivery technology that protects live ... to the intestinal tract. The randomized, double-blind, ...
(Date:7/28/2015)... The Physician-Patient Alliance for Health & Safety ... Surviving Your Hospital Stay ." "Help us ... of these patients went home from hospital," said ... referring to the patient stories presented at ... Promote Continuous Monitoring of Patients on Opioids (shown ...
(Date:7/28/2015)... TAMPA, Fla. , July 28, 2015  For ... by their researchers, physicians and other inventors can be ... to market is difficult, and successes are rare. ... wants to change that. Medical Device ... technology licensed from universities, hospitals and physicians. MDI develops, ...
Breaking Medicine Technology:Nutraceutix's L. reuteri Probiotic Clinically Proven to Modulate Gut Insulin Metabolism 2Surviving Your Hospital Stay: Physician-Patient Alliance for Health & Safety Launches Fundraising for Patient Safety 2Medical Device Investments To Become Center Of Excellence For The Commercialization Of Innovative Medical Technologies 2
... Significance, FRAZER, Pa., May 01, 2007 /PRNewswire-FirstCall/ ... presented today at the 59th Annual,Meeting of ... highlights,data demonstrating that FENTORA(R) (fentanyl buccal tablet) ... pain in patients,with neuropathic pain who are ...
... Inc. (NYSE:DNA),and Biogen Idec, Inc. (Nasdaq:BIIB) announced ... study of Rituxan(R) (rituximab) in,patients with relapsing-remitting ... American Academy of Neurology annual meeting,held in ... targets and,selectively depletes CD20-positive B-cells., "There remains ...
Cached Medicine Technology:Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 2Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 3Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 4Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 5Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 6Cephalon Presents Positive Results for Fentora in Breakthrough Pain,Associated with Neuropathic Conditions 7Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology 2Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology 3Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology 4Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology 5Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology 6
Galt Skull Trephine with adjustable centering point and detachable cross-bar handle, 19.0 mm....
Greenberg micro instrument holder is a flexbar arm used to hold micro instruments used repeatedly within retracted fields. Holds instruments with shafts up to 1/8 in diameter....
Length-9 (229 mm) Tapered retractor blades. 1/16 x 1/4 (1.6 mm x 19 mm)....
Kit is supplied with four secondary bars. Secondary bars attach to primary bar. Length 12 (305 mm)....
Medicine Products: