Navigation Links
Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer
Date:2/26/2013

PHILADELPHIA An increasing body mass index was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"We know that exercise and avoiding obesity decrease colorectal cancer risk, but little is known about why," said Shuji Ogino, M.D., Ph.D., associate professor of pathology at Dana-Farber Cancer Institute and associate professor in the Department of Epidemiology at Harvard School of Public Health in Boston, Mass. "In this study, we used a biomarker named CTNNB1, which is a molecule implicated in cancer and obesity, to divide patients into two groups, CTNNB1-positive and CTNNB1-negative."

Ogino and colleagues used data from more than 100,000 women from the Nurses' Health Study and more than 45,000 men in the Health Professionals Study to examine whether there was an association between body mass index (BMI) or exercise activity and colorectal cancer risk according to CTNNB1 expression status.

Among the study population, 2,263 individuals were diagnosed with colorectal cancer during follow-up. Tumor CTNNB1 expression data were available for 861 of these individuals, and 54 percent of these tumors were negative for CTNNB1 and 46 percent positive for the biomarker.

Increasing BMI by a 5.0 kg/m2 increment was associated with a 34 percent higher risk for CTNNB1-negative cancer, but was not associated with CTNNB1-positive cancer. In contrast, increasing physical activity level was associated with a significantly lower risk for CTNNB1-negative cancer. It was not associated with CTNNB1-positive cancer.

"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Ogino said. "If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity."

In addition, the data indicated that CTNNB1 could be a potential target for chemoprevention and treatment, according to Ogino. He called for more population-based, large-scale databases to facilitate molecular pathological epidemiology research.

"Currently, most population-based studies do not take tumor heterogeneity into consideration, and typically colon cancer is treated as a single disease," Ogino said. "We need to integrate molecular pathology and epidemiology in education and research to facilitate integrative science and improve public health."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Outdoor Fast-Food Ads Linked to Obesity, Study Suggests
2. Obesity, excess weight gain during pregnancy linked to heavier babies in African-American women
3. Researchers identify role for protein linked to obesity, type 2 diabetes
4. Use Social Media to Fight Childhood Obesity, Heart Experts Say
5. Study Supports Link Between Obesity, Cavities in Homeless Kids
6. In obesity, a micro-RNA causes metabolic problems
7. What babies eat after birth likely determines lifetime risk of obesity, rat study suggests
8. Obesity, larger waist size associated with better outcomes in heart failure patients
9. Wayne State University researcher seeks to understand link between obesity, flu severity
10. Obesity, A Contributing Cause Of Arthritis Of The Knee, Is Now Being Treated With Regenerative Medicine At The Center For Regenerative Medicine
11. Peaches, plums, nectarines give obesity, diabetes slim chance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... ... enhance people’s everyday lives, recently attended the January ECRM Trade Show in Hilton ... is known for its large range of supplements that keep the body functioning ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is Greater than Sin”: ... who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater than Sin” is the ... an educator interacting with countless women who had little knowledge of the female characters ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Christmas in Suffolk”: ... published author, Sara Seymour, who lives in Lafayette, Indiana where she works in a ... iced coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s new book ...
(Date:1/19/2017)... (PRWEB) , ... January 20, 2017 , ... Today, the ... to participate in four of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who ... patients. APMs are an important part of the Administration’s effort to build a ...
(Date:1/19/2017)... , ... January 19, 2017 , ... This month, the ... that the name of their drug rehab center in Delray Beach, Florida has been ... that not only stars such as Philip Seymour Hoffman and Chris Farley are dying ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
(Date:1/19/2017)... 2017 According to a study conducted by ... to witness a CAGR of 6.5% during the forecast period 2016-2024. ... continue to be the leading market for cryotherapy globally during the ... Highlights ... ensuring affordable and adequate supply of gas in order to provide ...
Breaking Medicine Technology: