Navigation Links
Obese men at high risk for prostate cancer even after benign biopsy
Date:4/23/2013

Obese men were more likely to have precancerous lesions detected in their benign prostate biopsies compared with non-obese men, and were at a greater risk for subsequently developing prostate cancer, according to researchers at Columbia University's Mailman School of Public Health. The findings will be published online in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Our study is focused on a large group of men who have had a prostate biopsy that is benign but are still at a very high risk for prostate cancer," said Andrew Rundle, DrPH, associate professor of Epidemiology and the first author of the paper. "Studies conducted in the past have attempted to determine if there are subpopulations of men diagnosed with benign conditions that may be at a greater risk for developing prostate cancer. Here we were able to show that obesity is associated with a significantly higher risk of prostate cancer after an initial benign biopsy, particularly in the first few years after a biopsy. This was also one of the first studies to assess the association between obesity and precancerous abnormalities in the benign biopsy tissue specimens."

Dr. Rundle and his colleagues investigated the association between obesity and future prostate cancer incidence within a cohort of 6,692 men at the Henry Ford Health System who were followed for 14 years after a biopsy or transurethral resection of the prostate with benign findings. The investigation was part of a larger study for prostate cancer funded through a research grant by the National Institutes of Health to the Henry Ford Health System.

The researchers conducted a case-control study among 494 of these patients and 494 matched controls; they found precancerous abnormalities in 11% of the patients' benign specimens. These abnormalities were significantly associated with obesity at the time of the procedure, according to Dr. Rundle.

After accounting for several variables, including family history of prostate cancer, prostate-specific antigen (PSA) levels during the initial procedure, and the number of PSA tests and digital rectal exams during follow-up, the researchers found that obesity at the time of the initial procedure was associated with a 57% increased incidence of prostate cancer during follow-up.

Dr. Rundle noted, however, that this association was only apparent for tumors occurring earlier in the follow-up period. "We don't absolutely know what the true biology is," he said. "In some ways, this reflects the association between the body size and larger prostate size, which is thought to reduce the sensitivity of the needle biopsy. It is possible that the tumors missed by initial biopsy grew and were detected in a follow-up biopsy."

The association observed between body size and prostate cancer risk is greater than that seen in prior studies, according to Dr. Rundle. He attributed the discrepancy to differences between the cohorts studied; the current study was composed only of men at high risk for prostate cancer. In addition, since these high-risk men were members of the comprehensive Henry Ford Medical System, they underwent increased medical surveillance, which included repeated biopsy and regular PSA screening.

"We need some guidance on when or for whom a full follow-up is required," said Dr. Rundle. "Obesity should be considered a factor for more intensive follow-up after a benign prostate biopsy."


'/>"/>

Contact: stephanie berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Some Slightly Obese May Gain From Weight-Loss Surgery, Guidelines Say
2. Scientists identify gene that is consistently altered in obese individuals
3. Lung Transplant Hazard May Rise With Obese Recipients, Smoking Donors
4. Obese New Mothers May Have Higher Heart Attack, Stroke Risk
5. Weight loss may prevent, treat osteoarthritis in obese patients
6. Procedure Lowers Hunger Hormone to Help Obese Lose Weight
7. Babies Born to Obese Women Show Thicker Arteries: Study
8. Exercise May Stave Off Depression in Severely Obese
9. Obese Black Women at Higher Risk for Having Very Large Babies
10. Caloric restriction, exercise help prevent weight gain, other complications in obese women
11. USC research finds certain contraceptive may pose risk of Type 2 diabetes for obese women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: