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'Obese but happy gene' challenges the common perception of link between depression and obesity
Date:11/20/2012

d to depression," Meyre said.

The McMaster researchers investigated the genetic and psychiatric status of patients enrolled in the EpiDREAM study led by the Population Health Research Institute, which analyzed 17,200 DNA samples from participants in 21 countries.

In these patients, they found the previously identified obesity predisposing genetic variant in FTO was associated with an eight per cent reduction in the risk of depression. They confirmed this finding by analyzing the genetic status of patients in three additional large international studies.

Meyre said the fact the obesity gene's same protective trend on depression was found in four different studies supports their conclusion. It is the "first evidence" that an FTO obesity gene is associated with protection against major depression, independent of its effect on body mass index, he said.

This is an important discovery as depression is a common disease that affects up to one in five Canadians, said Samaan.
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Contact: Thana Dharmarajah
dharmar@mcmaster.ca
905-525-9140
McMaster University
Source:Eurekalert

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