Navigation Links
Obese and overweight women face increased risk of recurrence of most common type of breast cancer
Date:8/26/2012

Extra poundseven within the overweight but not obese rangeare linked to a higher risk of recurrence of the most common type of breast cancer despite optimal cancer treatment, according to a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that extra body fat causes hormonal changes and inflammation that may drive some cases of breast cancer to spread and recur despite treatment.

Women who are obese when they are diagnosed with breast cancer have an increased risk of dying prematurely compared with women of normal weight. In this new study, Joseph Sparano, MD, of the Albert Einstein College of Medicine's Montefiore Medical Center, in Bronx, NY, and his colleagues across the US cancer cooperative groups compared the health outcomes of obese and overweight patients with others in a large group of women with stage I-III breast cancer who had participated in three National Cancer Institutesponsored treatment trials led by the Eastern Cooperative Oncology Group (now part of the ECOG-ACRIN Cancer Research Group). All of the trials (E1199, E5188, and E3189) required participants to have normal heart, kidney, liver, and bone marrow function, thereby excluding patients with other significant health issues. As a result, researchers were able to disentangle the influence of obesity from other factors affecting cancer recurrence and survival.

The researchers found that increasing body mass indexa measure of the body's fat contentsignificantly increased women's risk of cancer recurrence and death, despite optimal treatment including chemotherapy and hormonal therapy. There was a stepwise relationship between increasing body mass index and poor outcomes only in women with hormone receptorpositive breast cancer, the most common type of breast cancer that accounts for approximately two-thirds of all breast cancer cases in the United States and worldwide.

"We found that obesity at diagnosis of breast cancer is associated with about a 30 percent higher risk of recurrence and a nearly 50 percent higher risk of death despite optimal treatment," said Dr. Sparano. "Treatment strategies aimed at interfering with hormonal changes and inflammation caused by obesity may help reduce the risk of recurrence," he added.


'/>"/>
Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Related medicine news :

1. Many Obese Americans Struggle With Stigma, Discrimination, Poll Finds
2. Older Americans Living Longer, But Becoming More Obese
3. Fat Stats: 30% of Adults in 12 States Now Obese
4. Severely Obese Donors Raise Risks for Kids With Liver Transplant
5. Obese donors increase risk of death for pediatric liver transplant recipients
6. Obese Label May Not Apply to Heavy Ex-NFL Players
7. Obese Kids May Be at Higher Risk for Heart Disease
8. Babies Born to Obese Mothers May Have Low Iron: Study
9. Lower iron levels seen in newborns of obese mothers
10. Obese appendectomy patients have fewer complications with minimally invasive operations
11. Could Bloodletting Ease Heart Risks for the Obese?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... , ... “Journey to the Light: The Quest for Happiness and Love. . ... to finding herself. “Journey to the Light: The Quest for Happiness and Love. ... writer of newsletters, manuals, and articles, who has recently decided to expand her literary ...
(Date:7/23/2017)... (PRWEB) , ... July 23, 2017 , ... A ... in St. Louis, and led by the Minneapolis Veterans Administration Health Care System overwhelmingly ... of the disease offers very few benefits. , In the cases involved with ...
(Date:7/23/2017)... ... 23, 2017 , ... Technology is making it easier for ... tools are helping patients become more actively involved in their care and maintaining ... survey, released today by the American Hospital Association’s (AHA) Health Forum. , According ...
(Date:7/23/2017)... ... July 23, 2017 , ... Viora Ltd., a ... US Patent No. 9,038,640 by the United States Patent and Trademark Office. The ... combination of Switching, Vacuum, and Cooling mechanisms to further increase the efficacy and ...
(Date:7/21/2017)... ... July 21, 2017 , ... "As a doctor of lung medicine ... catheters available on the market," said an inventor from Center Valley, Pa. "My idea ... the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT to offer an ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... 11, 2017  The global market for liquid biopsy ... $394.1 million in 2016.  Although in early stages, the ... in particular as a result of the gradual shift ... recent introduction of a significant number of new liquid ... of tumor biomarkers to guide treatment decisions. ...
(Date:7/10/2017)... , July 10, 2017 The Institute for ... methods, is the recipient of a VITROCELL® inhalation exposure ... International Science Consortium. The device, which is designed to ... expose human lung cells to airborne test materials in ... use the VITROCELL® system for testing combustible tobacco products, ...
(Date:7/5/2017)... 5, 2017 Wolfmet 3D  printed tungsten collimator manufactured by ... and manufacturing combine to progress molecular radiotherapy imaging. ... are unable to accurately quantify the radiation absorbed by those ... the success of this radiotherapy treatment has been available — ... ...
Breaking Medicine Technology: