Navigation Links
Obese and overweight women face increased risk of recurrence of most common type of breast cancer
Date:8/26/2012

Extra poundseven within the overweight but not obese rangeare linked to a higher risk of recurrence of the most common type of breast cancer despite optimal cancer treatment, according to a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that extra body fat causes hormonal changes and inflammation that may drive some cases of breast cancer to spread and recur despite treatment.

Women who are obese when they are diagnosed with breast cancer have an increased risk of dying prematurely compared with women of normal weight. In this new study, Joseph Sparano, MD, of the Albert Einstein College of Medicine's Montefiore Medical Center, in Bronx, NY, and his colleagues across the US cancer cooperative groups compared the health outcomes of obese and overweight patients with others in a large group of women with stage I-III breast cancer who had participated in three National Cancer Institutesponsored treatment trials led by the Eastern Cooperative Oncology Group (now part of the ECOG-ACRIN Cancer Research Group). All of the trials (E1199, E5188, and E3189) required participants to have normal heart, kidney, liver, and bone marrow function, thereby excluding patients with other significant health issues. As a result, researchers were able to disentangle the influence of obesity from other factors affecting cancer recurrence and survival.

The researchers found that increasing body mass indexa measure of the body's fat contentsignificantly increased women's risk of cancer recurrence and death, despite optimal treatment including chemotherapy and hormonal therapy. There was a stepwise relationship between increasing body mass index and poor outcomes only in women with hormone receptorpositive breast cancer, the most common type of breast cancer that accounts for approximately two-thirds of all breast cancer cases in the United States and worldwide.

"We found that obesity at diagnosis of breast cancer is associated with about a 30 percent higher risk of recurrence and a nearly 50 percent higher risk of death despite optimal treatment," said Dr. Sparano. "Treatment strategies aimed at interfering with hormonal changes and inflammation caused by obesity may help reduce the risk of recurrence," he added.


'/>"/>
Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Related medicine news :

1. Many Obese Americans Struggle With Stigma, Discrimination, Poll Finds
2. Older Americans Living Longer, But Becoming More Obese
3. Fat Stats: 30% of Adults in 12 States Now Obese
4. Severely Obese Donors Raise Risks for Kids With Liver Transplant
5. Obese donors increase risk of death for pediatric liver transplant recipients
6. Obese Label May Not Apply to Heavy Ex-NFL Players
7. Obese Kids May Be at Higher Risk for Heart Disease
8. Babies Born to Obese Mothers May Have Low Iron: Study
9. Lower iron levels seen in newborns of obese mothers
10. Obese appendectomy patients have fewer complications with minimally invasive operations
11. Could Bloodletting Ease Heart Risks for the Obese?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/19/2017)... ZirMed Inc ., a recognized leader in cloud-based revenue cycle ... ranked #1 by its users for the seventh consecutive year ... ZirMed was recognized as the top-ranked end-to-end revenue cycle management ... 200 beds and holds one of the longest #1 ranking ... ...
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has ... the Atlanta Football Host Committee (AFHC) for the 2018 College ... Jan. 8, 2018, at Mercedes-Benz Stadium in Atlanta, ... of the AFHC "I,m In" campaign, participating in many activities ... ...
Breaking Medicine Technology: