Navigation Links
OTC Drugs May Work Differently in Obese Kids
Date:4/27/2010

Researcher suggests considering weight factors when deciding dosage,,

TUESDAY, April 27 (HealthDay News) -- Children who are overweight or obese appear to metabolize over-the-counter drugs differently than normal-weight children, a new study finds.

This could result in complications at both ends of the spectrum, whether kids' bodies end up with more drug than they need or less.

"There could be severe implications," said L'Aurelle Johnson, senior author of the research, which was to be presented Tuesday in Anaheim, Calif., at a meeting of the American Society for Pharmacology and Experimental Therapeutics, part of the Experimental Biology 2010 conference.

"There could be adverse effects if the therapeutic agent is metabolized into an active form," she explained. "They could have higher systemic circulation of this particular agent, and they might have adverse events due to [overly] high concentrations in the system."

On the contrary, if the therapeutic agent is metabolized into an inactive form, therapeutic thresholds might not be met, meaning the child would not benefit from the drug, she explained.

Though it's long been known that adults who are overweight metabolize drugs differently than their normal-weight counterparts, there has been little similar research done in kids, according to the researchers.

"Because of the increase in obesity in the pediatric population, we need to know how being overweight or obese affects how drugs are metabolized in the system," Johnson said.

Johnson and a co-author looked at how both dextromethorphan (the active ingredient in over-the-counter Robitussin DM) and caffeine (delivered via a cola drink) were metabolized by 16 normal-weight and nine obese children, 6 to 10 years old. All of the children were black.

Specifically, the authors measured activity levels of two key enzymes involved in drug metabolism.

They foun
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New Drugs, New Combinations Fight Breast Cancer
2. NICE guidelines ration affordable osteoporosis drugs
3. Bone Drugs May Beat Back Breast Cancer
4. Rehabilitation for Opiate Addiction Without Maintenance Drugs
5. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
6. Fake Drugs Bought on the Web Pose Big Health Risks
7. Scientists show how molecular switch helps pancreatic cancer beat drugs
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Counterfeit Internet drugs pose significant risks and discourage vital health checks
10. Fertility drugs contribute heavily to multiple births
11. Scientists show how brain tumors outsmart drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... (PRWEB) August 21, 2014 Transvaginal ... Bard, Inc. continue to move forward in the ... Southern District of West Virginia, Bernstein Liebhard LLP ... August 14th, the Court has established new stipulated ... special handling, division, storage and preservation. (In re ...
(Date:8/21/2014)... care physicians in rural communities do not routinely ... to Penn State medical and public health researchers. ... have limited resources if they seek help., "Rural ... women," said Jennifer S. McCall-Hosenfeld, a primary care ... health sciences, Penn State College of Medicine. "However, ...
(Date:8/21/2014)... London, UK (PRWEB) August 21, 2014 ... from USD 15.6 billion in 2014 and reach USD ... during the forecast period. The drivers of such growth ... products, rising obese and diabetic population, and surging ageing ... costs of state-of-the-art wound care products. Region-wise, North America ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Lauren Collura, a ... the 2014 “Back to the Boardwalk” Facebook sweepstakes. Lauren, her ... a beautiful four-bedroom beachfront house in Lavallette beginning this Saturday. ... to the Boardwalk” sweepstakes. Last year, Horizon Blue Cross Blue ... communities after Superstorm Sandy and decided to make it a ...
(Date:8/21/2014)... THURSDAY, Aug. 21, 2014 (HealthDay News) -- In a ... that pregnant women avoid eating tuna due to concerns ... tuna, which is second only to shrimp as the ... encourage pregnant women to avoid all tuna," Jean Halloran, ... advocacy division of Consumer Reports, said in a news ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:Primary care physicians can be critical resource for abused women in rural areas 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 3Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2
... Nov. 5 Attorneys from Dallas, Rasansky Law Firm ... court on behalf of the mother of a 2-year-old girl who ... year ago. The lawsuit includes claims that the day care,s owners ... the child,s death from showing up on a state licensing database. ...
... is pleased to announce their standing in the latest ... quick, confidential performance ratings and comparisons of technology vendors, ... overall in their Q3 2009 Customer Satisfaction Industry Report. ... customer satisfaction score was the lowest ever reported by ...
... FRANCISCO, Nov. 5 Quantros, Inc., an industry leader ... point of care data surveillance solutions, today announced the ... ), a publicly traded company spun off from Cardinal ... were not disclosed. , This latest addition to ...
... Investments to ... ... nonprofit venture capital firm that invests in entrepreneurs who are building businesses to serve the ... Hill Eye and Laser Centre (UHEAL) in Kenya, both of which provide advanced eye care ...
... study finds, , THURSDAY, Nov. 5 (HealthDay News) -- What ... a good night,s sleep come more easily. , A study ... the odds of having disturbed sleep in the seven years ... years before they stopped working. , Sleep improvements probably had ...
... , WATSONVILLE, Calif., Nov. 5 Nordic Naturals ... especially for pregnant women to ensure adequate DHA, an ... for the new mother and developing baby. Prenatal DHA ... the leading non-profit organization in the United States that ...
Cached Medicine News:Health News:The Rasansky Law Firm Announces Dallas Day Care Death Lawsuit; State Investigation Finds Evidence of Negligence at Woodbridge Day School 2Health News:ChemSW Rated Top Vendor Overall for Customer Satisfaction in Q3 2009 by VendorRate 2Health News:Quantros Acquires MediQual(TM) From CareFusion Corporation 2Health News:Quantros Acquires MediQual(TM) From CareFusion Corporation 3Health News:Acumen Fund Announces Two Investments Providing Advanced Eye Care Services in India and Kenya 2Health News:Acumen Fund Announces Two Investments Providing Advanced Eye Care Services in India and Kenya 3Health News:Acumen Fund Announces Two Investments Providing Advanced Eye Care Services in India and Kenya 4Health News:Without Job Stress, Retirees Sleep Better 2Health News:Nordic Naturals Professional Exclusive Division Introduces Prenatal DHA An Omega-3 Fatty Acid Supplement for Pregnant Women 2
(Date:8/21/2014)... , Aug. 21, 2014 Professional ... in paediatric medicine by awarding the three best ... Formulation initiative (EuPFI) conference . The Formulating ... – 18 in Athens, Greece ... pharmacy students and professionals, from which three winners ...
(Date:8/21/2014)... , Aug. 21, 2014   Royal ... PHIA) today announced it has received 510(k) clearance ... market its precision planning application for Transcatheter Aortic-Valve ... TAVI application provides interventionalists with pre-procedural, high-precision positioning ... Philips TAVI planning application is available as part ...
(Date:8/21/2014)... JOSE, Calif. , Aug. 21, 2014  SI-BONE, ... medical device company that pioneered the use of the ... (MIS) device indicated for fusion of the sacroiliac (SI) ... ) published an update to its Lumbar Fusion Medical ... SI joint fusion procedure.  The policy states that the ...
Breaking Medicine Technology:Professional Compounding Centers of America will award top poster-session winners at European Paediatric Formulation Initiative in Athens 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 2SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 3
... KVM Switches to be First Units to Sport New ... ... ATEN Technology, Inc., an,innovator of high-quality KVM (keyboard/video/mouse) and remote,connectivity ... the first LCD KVM switches to feature,product-protected antimicrobial nanocoating. The ...
... LA JOLLA, Calif., Sept. 10 TorreyPines,Therapeutics, Inc. ... its third,Phase I clinical trial for NGX267, in ... with schizophrenia (CIAS). The,compound, a functionally selective muscarinic ... when given orally to healthy male volunteers,once-daily for ...
Cached Medicine Technology:Keeping the Data Center Clean: ATEN Launches Industry-First KVM Switches with Antimicrobial Nanocoating to Protect Products from Bacteria Surviving on Surfaces 2Keeping the Data Center Clean: ATEN Launches Industry-First KVM Switches with Antimicrobial Nanocoating to Protect Products from Bacteria Surviving on Surfaces 3Keeping the Data Center Clean: ATEN Launches Industry-First KVM Switches with Antimicrobial Nanocoating to Protect Products from Bacteria Surviving on Surfaces 4TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia 2TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia 3
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 100-1,000 microliter range....
... Pipettor is the #1 Pipettor for ... comfort, and reliability. Continuously adjustable. Features ... sub-micrometer. Easy interchangeable ejector buttons to ... Adjustable rapid pipet tip ejector with ...
... adjustable, air-displacement pipette with a patented multifunctional ... of the Pipetman family, sharing many of ... We also added a number of features ... models cover the full range of volumes ...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Medicine Products: