Navigation Links
OTC Drugs May Work Differently in Obese Kids
Date:4/27/2010

Researcher suggests considering weight factors when deciding dosage,,

TUESDAY, April 27 (HealthDay News) -- Children who are overweight or obese appear to metabolize over-the-counter drugs differently than normal-weight children, a new study finds.

This could result in complications at both ends of the spectrum, whether kids' bodies end up with more drug than they need or less.

"There could be severe implications," said L'Aurelle Johnson, senior author of the research, which was to be presented Tuesday in Anaheim, Calif., at a meeting of the American Society for Pharmacology and Experimental Therapeutics, part of the Experimental Biology 2010 conference.

"There could be adverse effects if the therapeutic agent is metabolized into an active form," she explained. "They could have higher systemic circulation of this particular agent, and they might have adverse events due to [overly] high concentrations in the system."

On the contrary, if the therapeutic agent is metabolized into an inactive form, therapeutic thresholds might not be met, meaning the child would not benefit from the drug, she explained.

Though it's long been known that adults who are overweight metabolize drugs differently than their normal-weight counterparts, there has been little similar research done in kids, according to the researchers.

"Because of the increase in obesity in the pediatric population, we need to know how being overweight or obese affects how drugs are metabolized in the system," Johnson said.

Johnson and a co-author looked at how both dextromethorphan (the active ingredient in over-the-counter Robitussin DM) and caffeine (delivered via a cola drink) were metabolized by 16 normal-weight and nine obese children, 6 to 10 years old. All of the children were black.

Specifically, the authors measured activity levels of two key enzymes involved in drug metabolism.

They found higher enzyme activity among the obese children who were given caffeine, but not among those who took dextromethorphan.

"This means that there is variability in enzyme activity, which has implications for furthering personalized medicine," said Johnson, who is an assistant professor of experimental and clinical pharmacology at the University of Minnesota College of Pharmacy. "We might need to take into account a child's physiological condition -- whether they're obese or non-obese -- when determining dosing."

Johnson also plans to look at how the activities of additional enzymes might be altered in obese children.

More information

The Institute for Safe Medication Practices has information on avoiding medication errors.



SOURCES: L'Aurelle Johnson, Ph.D., assistant professor, experimental and clinical pharmacology, University of Minnesota College of Pharmacy, Minneapolis; presentation, American Society for Pharmacology and Experimental Therapeutics annual meeting, April 24-28, 2010, Anaheim, Calif.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Drugs, New Combinations Fight Breast Cancer
2. NICE guidelines ration affordable osteoporosis drugs
3. Bone Drugs May Beat Back Breast Cancer
4. Rehabilitation for Opiate Addiction Without Maintenance Drugs
5. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
6. Fake Drugs Bought on the Web Pose Big Health Risks
7. Scientists show how molecular switch helps pancreatic cancer beat drugs
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Counterfeit Internet drugs pose significant risks and discourage vital health checks
10. Fertility drugs contribute heavily to multiple births
11. Scientists show how brain tumors outsmart drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
Breaking Medicine Technology: