Navigation Links
OSA increases cardiovascular mortality in the elderly
Date:9/6/2012

Untreated severe obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular mortality in the elderly, and adequate treatment with continuous positive airway pressure (CPAP) may significantly reduce this risk, according to a new study from researchers in Spain.

"Although the link between OSA and cardiovascular mortality is well established in younger patients, evidence on this relationship in the elderly has been conflicting," said lead author Miguel ngel Martnez-Garca, MD, of La Fe University and Polytechnic Hospital in Valencia, Spain. "In our study of 939 elderly patients, severe OSA not treated with CPAP was associated with an increased risk of cardiovascular mortality especially from stroke and heart failure, and CPAP treatment reduced this excess of cardiovascular mortality to levels similar to those seen in patients without OSA."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

All subjects in this prospective, observational study were 65 years of age or older. Median follow-up was 69 months. Sleep studies were conducted with either full standard polysomnography or respiratory polygraphy following Spanish guidelines. OSA was defined as mild-to-moderate (apnea-hypopnea index [AHI] 15-29) or severe (AHI ≥30). Patients with AHI <15 acted as controls. CPAP use ≥4 hours daily was considered as good adherence to treatment.

Compared with the control group, the adjusted hazard ratios for cardiovascular mortality were 2.25 (CI, 1.41 to 3.61) for patients with untreated severe OSA, 0.93 (CI, 0.46 to 1.89) for patients treated with CPAP and 1.38 (CI, 0.73 to 2.64) for patients with untreated mild-to-moderate OSA. Similar results were observed among the subgroup of patients ≥75 years of age. Among patients who initiated CPAP treatment, compliance was independently associated with a reduced risk of cardiovascular mortality.

The study had a few limitations, including that the study was not randomized, the reduced statistical power in the subgroup analyses, and the use of respiratory polygraphy to diagnose OSA in a number of patients. Strengths included being the large study size including exclusively elderly patients and the long follow-up.

"This is the first large-scale study to examine the impact of OSA on cardiovascular mortality in a series including exclusively elderly patients and assess the effectiveness of CPAP treatment in reducing this risk," said Dr. Martnez-Garca. "Our finding that adequate CPAP treatment is associated with significant reductions in cardiovascular mortality in patients with OSA has important implications, especially given the increasing elderly population."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Prenatal diagnosis of congenital heart disease increases maternal stress, depression, and anxiety
2. Smoking after stroke increases death risk by 3-fold
3. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
4. Lack of food increases hospital use by HIV-infected urban poor in SF
5. Smoking during pregnancy increases the risk of wheeze and asthma in preschool children
6. Pan-fried meat increases risk of prostate cancer, new study finds
7. Pre-test genetic counseling increases cancer knowledge for BRCA patients
8. Smoking increases, while alcohol consumption may decrease risk of ALS
9. As a mans belt size increases, so does his risk of sexual and urinary dysfunction
10. Diagnostic imaging increases among stage IV cancer patients on Medicare
11. Severe flu increases risk of Parkinsons: UBC research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... York (PRWEB) , ... May 24, 2016 , ... WaterAid launched the #perioddrama ... faced by more than 1 billion women around the world who do not have access ... women from across the US about their dread of #perioddrama. The (sometimes hilarious) results help ...
(Date:5/24/2016)... ... May 24, 2016 , ... Harvard Health ... licensing relationship that will deliver a new series of Q&A videos to clinicians ... medical knowledge and expertise of Harvard Medical School faculty into brief videos that ...
(Date:5/24/2016)... ... May 24, 2016 , ... Clarion Safety Systems , ... labels , has been featured in the National Electrical Manufacturers Association’s (NEMA) newsletter, ... electroindustry professionals with manufacturer, regulatory, and standardization news. The publication is a bi-monthly ...
(Date:5/24/2016)... ... 24, 2016 , ... After graduating from Cornell, author Joshua Alexander ... on medication, living on Social Security disability and staying in a group home. In ... It!” (published by Balboa Press), Alexander shares how he was finally able to heal ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... announces the grand opening of ‘El Centro del Quinto Sol Wheel Park’ in ... Pueblo ‘east side’ community to offer something special for this often overlooked neighborhood. ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LAWRENCE, Mass. , May 24, 2016  NxStage ... medical technology company focused on advancing renal care, today ... Officer, plans to participate in the following schedule of ... will be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, ...
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse à ... destinés à l,intervention portant sur les membres ... OrbusNeich, entreprise mondiale spécialisée dans ... changer la vie, a élargi son portefeuille ...
(Date:5/23/2016)... PUNE, India , May 23, 2016 ... is spread across 163 pages, profiles 12 companies and ... 280 tables and figures on the industry and its ... study that is comprehensive in nature, details the current ... of the industry including definitions, classifications, applications and industry ...
Breaking Medicine Technology: