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OROS(R) Methylphenidate in Adults with ADHD: New Insights
Date:5/7/2008

ROS(R) MPH vs. 5.2% for placebo). BP or HR increase led to down titration in 4.5% (5/110) of OROS(R) MPH patients and 0.9% (1/116) of placebo patients.

The studies were presented and sponsored by J&JPRD, which filed for U.S. approval of OROS(R) MPH for the treatment of adult ADHD last year.

The following New Research Posters on OROS(R) MPH will be presented today at APA:
NR6-019: Cardiovascular Safety Data From a Long-Term, Open-Label Study of

OROS(R) MPH in Adults with ADHD

NR6-017: A Long-Term Safety Study of OROS(R) Methlyphenidate in Adults

with ADHD

NR6-034: Cardiovascular Effects of OROS(R) MPH in a Dose-Titration Study

of Adults with ADHD

NR6-014: Treatment Response with OROS(R) MPH in a Dose-Titration Study of

Adults with ADHD

NR6-010: Clinician-Rated and Patient-Rated Symptom Improvement in a

Double-Blind, Placebo-Controlled, Dose-Titration Study of OROS(R) MPH in

Adults with ADHD

NR6-005: Efficacy of OROS(R) MPH in a Double-Blind, Placebo-Controlled,

Dose-Titration Study of Adults with ADHD: Secondary Endpoints

*Dr. Adler has been a consultant, served on advisory boards and received research grants from J&JPRD and McNeil Pediatrics(TM), Division of Ortho- McNeil-Janssen Pharmaceuticals, Inc.

About ADHD

Attention Deficit Hyperactivity Disorder (ADHD) is a common and treatable neuropsychiatric condition, which includes inattention, hyperactivity and impulsivity. According to the National Institutes of Mental Health (NIMH), ADHD is one of the most common mental disorders in childhood. It affects an estimated four million children and adolescents in the United States.

Important Safety Information

OROS(R) MPH should not be taken by patients with: significant anxiety, tension or agitation; allergies to methylphenidate or other ingredients in OROS(R) MPH; glaucoma; Tourette's syndrome, tics or family history of Tourette's syndr
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SOURCE McNeil Pediatrics(TM), Division of Ortho-McNeil-Janssen
Copyright©2008 PR Newswire.
All rights reserved

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