Navigation Links
OHSU vaccine research targets HIV in the slower, early stage of infection
Date:2/17/2009

PORTLAND, Ore. New research at Oregon Health & Science University's Vaccine and Gene Therapy Institute suggests vaccines that specifically target HIV in the initial stages of infection before it becomes a rapidly replicating, system-wide infection - may be a successful approach in limiting the spread of the disease. The research is published in the early online edition of the journal Nature Medicine and will appear in a future printed edition.

The researchers used a vaccination method that involves creating and maintaining resistance by programming a portion of the body's immune system effector memory T-cells to look out for HIV at the site of infection.

"HIV appears to be vulnerable when it is first introduced into mucosal surfaces in the body," said Louis Picker, M.D., associate director of the OHSU VGTI and director of the VGTI's vaccine program. "However, once HIV spreads throughout the entire body, it replicates very rapidly and becomes difficult if not impossible to control. Our approach is to attack during this early period of vulnerability. The approach is similar to that of a homeowner who sprays their house with water before sparks land on the roof. This approach can prevent the roof from catching fire and, in the case of HIV, prevent the spread of the virus."

To determine whether they could proactively "educate" the immune system, scientists used a monkey model of AIDS - simian immunodeficiency virus (SIV) the monkey counterpart to HIV. They introduced an altered monkey form of cytomegalovirus (CMV) programmed to express SIV proteins and trigger specialized effector memory T-cells to look for and attack SIV in its early stages.

In total, 12 rhesus macaque monkeys at the Oregon National Primate Research Center were vaccinated using this method. When the animals were later infected with SIV, one-third were protected.

The next step for the research team is to try to determine why only a port
'/>"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sponsor Dollars Key to Flu Vaccine Study Publication
2. Federal Vaccine Court Rulings Against Autism Families Due to Governments Refusal to Fund Sound Science
3. Parents and Advocates Label Todays Vaccine Court Rulings Insincere and Politically Driven, Says National Autism Association
4. Court Says Vaccine Not the Cause of Autism
5. Federal Court Declares Vaccines Do Not Cause Autism
6. New test may help to ensure that dengue vaccines do no harm
7. Video: Pampers Together with Actress Salma Hayek Helps UNICEF Move Closer Toward Goal of Eliminating Deadly Tetanus Through Global One Pack = One Vaccine Campaign
8. Federal Members of Advisory Committee Block Vaccine-Autism Research, Defy Wishes of Its Own Scientists, Autism Community, and Congress
9. FFF Enterprises Launches New MyFluVaccine Website
10. Meningitis Vaccine Seems to Work Like a Charm
11. Novel Vaccines Improve Potential for European Vaccines Manufacturers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... 2015 The Hon. Ellen Tauscher, Independent ... the following statement following the deadly earthquake in Nepal: ... resulting in the deaths of more than 1,000 people. ... across Nepal, Bangladesh, India and other parts of South ... to the people of Nepal and the families of ...
(Date:4/25/2015)... York, NY (PRWEB) April 25, 2015 By ... technology and data for the enterprise relying on their judgement ... running smoothly. But according to an article published ... can many times actually be doing a disservice to their ... i’s are dotted and t’s are crossed when it comes ...
(Date:4/25/2015)... Parker and Sons projects growth in 2015. The demand ... alongside the growing economy. As a result, Parker and Sons ... help account for the rising need for heating, cooling, and ... we are enthusiastic about. It means growth for us, and ... and Sons. , Indeed, Parker and Sons has been contributing ...
(Date:4/25/2015)... Minnesota (PRWEB) April 25, 2015 For thirteen ... the premier income protection education event in the nation! This ... with The Plus Group, US to take DI Day on ... , George G. Davidson, CLU, ChFC, RHU, DIA, CLTC, Chief ... Cities DI Day reflects on the change by stating, "The ...
(Date:4/24/2015)... As the nation recognizes the Month ... of these young men and women, the “Alaska – ... their Families” presents a special training session on Adverse ... a better understanding of the effect of childhood trauma ... – civilian and military – who provide services and ...
Breaking Medicine News(10 mins):Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5Health News:Parker and Sons Plans to Expand in 2015 2Health News:Secura Consultants Takes DI Day On The Road 2Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2
... high levels of job strain have higher blood pressure ... study in the Journal// of Occupational and Environmental Medicine. ... combined with low control or decision-making ability over one's ... not just during the work day but also at ...
... revealed that smoking and binge drinking among teenage girls ... make the health risks seem less important than those ... Accordingly, young people correctly see cigarettes and alcohol as ... change to reflect that, Ofsted opined. Pupils also felt ...
... AMA President, Dr Mukesh Haikerwal, said today that the ... be the priority of any health reforms// that come ... ,Dr Haikerwal said patients would be the ... the right thing and sign up to the Federal ...
... the number of organ donors, Ontario’s health ministry is considering// ... pay to living donors. The health minister has promised ... ,British Columbia coughs up nearly $5,500 as expense for ... With this scheme, nearly 43 living donors have been reimbursed ...
... afflict stroke patients, in the process// revealing that one may ... ,Researchers at Washington University School of Medicine in St. Louis ... the putamen is strongly linked to motor neglect, a condition ... ,Like stroke patients with motor neglect, Parkinson's ...
... of how the brain of a premature infant responds to ... brain but// also identified at least one significant difference. ... researchers showed for the first time that parts of the ... system messenger compound. Glutamate is already well-known for its links ...
Cached Medicine News:Health News:High Job Strain Linked to Increased Blood Pressure 2Health News:Parents To Blame For Soaring Counts Of Binge-Drinkers And Smokers 2Health News:Drugs for Parkinson’s May Be Useful for Stroke-related Disabilit 2Health News:Drugs for Parkinson’s May Be Useful for Stroke-related Disabilit 3Health News:Drugs for Parkinson’s May Be Useful for Stroke-related Disabilit 4Health News:Different Approach Needed to Protect Brains of Premature Babies 2Health News:Different Approach Needed to Protect Brains of Premature Babies 3
(Date:4/25/2015)... April 25, 2015  With the introduction of Elekta,s ... cranial radiosurgery are now available for more patients with ... latest generation stereotactic radiosurgery system for the brain, integrates ... increasing the versatility of Gamma Knife radiosurgery. Elekta unveiled ... ESTRO Forum in Barcelona . ...
(Date:4/24/2015)... , April 24, 2015   Bernstein ... Pharmaceuticals, Inc. ("Aerie" or the "Company") (NASDAQ: ... to investors in violation of the federal securities ... Aerie breached their fiduciary duties to shareholders. ... on the discovery, development and commercialization of first-in-class ...
(Date:4/24/2015)... -- Bayer Corporation hosted its annual "Take Your Child to Work ... headquarters.  This is Bayer,s second "Take Your Child To Work ... campus, and Thursday,s event welcomed 230 children ready to see ... Fortunately, for the kids, this was not just another ... "Science For A Better Life," Bayer made sure that "Take ...
Breaking Medicine Technology:New Leksell Gamma Knife to benefit more patients with brain disease 2New Leksell Gamma Knife to benefit more patients with brain disease 3Bernstein Liebhard LLP Investigates Claims On Behalf Of Those Who Invested In Aerie Pharmaceuticals, Inc. 2Bayer Hosts "Take Your Child to Work Day" 2Bayer Hosts "Take Your Child to Work Day" 3Bayer Hosts "Take Your Child to Work Day" 4
... VIEW, Calif., Dec. 21, 2010 MAP Pharmaceuticals, Inc. (Nasdaq: ... ™ open-label safety trial.  The Company has now completed ... (NDA) for LEVADEX and plans to submit an NDA in ... inhaled migraine therapy that has completed Phase 3 clinical development ...
... -- China Botanic Pharmaceutical Inc. (AMEX: CBP ... and distributor of botanical products, bio-pharmaceuticals and traditional Chinese ... considerable progress in its efforts to comply with the ... 404") for fiscal year 2010. As announced ...
Cached Medicine Technology:MAP Pharmaceuticals Announces Completion of LEVADEX™ Open-Label Safety Trial 2MAP Pharmaceuticals Announces Completion of LEVADEX™ Open-Label Safety Trial 3China Botanic Announces Progress on its SOX 404 Compliance Program 2China Botanic Announces Progress on its SOX 404 Compliance Program 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: