Navigation Links
OHSU researchers discover potential way to repair brain damage in multiple sclerosis
Date:10/31/2012

PORTLAND, Ore. Researchers at Oregon Health & Science University have discovered that blocking a certain enzyme in the brain can help repair the brain damage associated with multiple sclerosis and a range of other neurological disorders.

The discovery could have major implications for multiple sclerosis, complications from premature birth and other disorders and diseases caused by demyelination a process where the insulation-like sheath surrounding nerve cells in the brain becomes damaged or destroyed. Demyelination disrupts the ability of nerve cells to communicate with each other, and produces a range of motor, sensory and cognitive problems in MS and other disorders.

The study was published this week in the online edition of the Annals of Neurology. The study was conducted by a team of researchers led by Larry Sherman, Ph.D., who is a professor of cell and development biology at OHSU and a senior scientist in the Division of Neuroscience at the Oregon National Primate Research Center.

"What this means is that we have identified a whole new target for drugs that might promote repair of the damaged brain in any disorder in which demyelination occurs," Sherman said. "Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders."

Sherman's lab has been studying MS and other conditions where myelin is damaged for more than 14 years. In 2005, he and his research team discovered that a sugar molecule, called hyaluronic acid, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord lesions. Their findings at the time, published in Nature Medicine, suggested that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from differentiating in areas of brain damage.

The new study shows that the hyaluronic acid itself does not prevent the
'/>"/>

Contact: Todd Murphy
murphyt@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
2. Common Antidepressants Too Risky During Pregnancy, Researchers Say
3. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
4. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
5. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
6. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
7. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
8. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
9. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
10. Mount Sinai researchers identify predictors for inpatient pain
11. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... ... a reputable source of authentic USA vs. Australia tickets at Ford Field in ... in conjunction with their Victory Tour to celebrate winning the 2015 Women's World Cup by ... awarded the Golden Ball as the best player of the 2015 Women's World Cup. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Eldermark Software, the ... Center for Aging Services Technologies (CAST) Medication Management Technologies whitepaper. The whitepaper is ... providers understand the benefits of using medication management technologies . ...
(Date:7/31/2015)... McLean, VA (PRWEB) , ... July 31, 2015 , ... ... solution at OSEHRA 2015. , What is HITaaS? Health IT as a Service (HITaaS) ... (IaaS) and software as a service (SaaS). , HITaaS manages all aspects ...
(Date:7/31/2015)... ... ... Physical therapy for knee osteoarthritis is an important part of knee ... patient from doing what they want or need to do. The patient may have trouble ... The patient's exercise regime may be limited by the pain in their knee. When a ...
(Date:7/31/2015)... McMinnville, OR (PRWEB) , ... July 31, 2015 , ... ... the Granary District Stage Amphitheater in McMinnville, Oregon August 15th, 2015 from 9am – ... is an exciting and important day for the entire community as the culmination of ...
Breaking Medicine News(10 mins):Health News:Cheap USA vs. Australia Tickets at Ford Field in Detroit, MI: Ticket Down Slashes Ticket Prices for Australia vs. USWNT International Friendly Match at Ford Field 2Health News:LeadingAge Selects Eldermark Case Study to Highlight Medication Error Reduction Results 2Health News:LeadingAge Selects Eldermark Case Study to Highlight Medication Error Reduction Results 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 2Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 4Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 2Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 3Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 2Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 3
... 2010 Elsevier, a world-leading publisher of scientific, ... announced the launch of SciVerse, an innovative platform ... the scientific community to collaborate on the development ... committed to releasing the APIs (application programming interfaces) ...
... French . The medicinal use of cannabis has ... large for many years as an alternative to standard pharmaceutical ... may have unwanted side effects. A new study by McGill ... that cannabis may offer relief to patients suffering from chronic ...
... , SUNDAY, Aug. 29 (HealthDay News) -- Having a particular ... risk of getting migraines, new research shows. While migraines ... specific genes has proven difficult, the researchers said. The ... genetic variant associated with a heightened risk for the most ...
... people suffering chronic pain, smoked cannabis reduces pain, ... research published in CMAJ (Canadian Medical Association Journal) ... who suffer from chronic neuropathic pain due to ... few treatment options. These options include opioids, anticonvulsants, ...
... Many children are being put at risk by parents over-use ... and colds, says a study from Australia to be presented ... today (Monday 30 August). The researchers, led ... South Wales, say that dosing errors and inappropriate use of ...
... FRIDAY, Aug. 27 (HealthDay News) -- While attention-deficit hyperactivity disorder ... there is a cluster of kids and adults who successfully ... privileges in school. "People who want to fake ADHD ... on a number of standard clinical instruments that are used ...
Cached Medicine News:Health News:Elsevier introduces SciVerse, an innovative platform for accelerating science 2Health News:Research demonstrates benefits of medical cannabis as a treatment for chronic pain 2Health News:New Migraine Gene Discovered 2Health News:New Migraine Gene Discovered 3Health News:Smoked cannabis reduces chronic pain 2Health News:Widespread parental misuse of medicines puts children at risk 2Health News:Widespread parental misuse of medicines puts children at risk 3Health News:Some Fake ADHD to Get Meds, Special Treatment 2Health News:Some Fake ADHD to Get Meds, Special Treatment 3
(Date:7/30/2015)... and VANCOUVER , July 30, 2015 ... today that it will report its second quarter 2015 ... will host a conference call and live webcast at ... financial results, clinical development programs and a general corporate ... on to the Investor Relations page of the OncoGenex ...
(Date:7/30/2015)... FALLS, Ohio , July 30, 2015  Cleveland ... his OMTEC® 2015 keynote address last month that industry ... models in order to gain the efficiencies—and develop the ... Dr. Barsoum,s comments were preceded by ... avid entrepreneur and OMTEC moderator, who stressed that industry ...
(Date:7/30/2015)...  Medimetriks Pharmaceuticals, Inc. announced today that its ... study for Ozenoxacin, a novel bactericidal non-fluorinated quinolone ... U.S. rights to Ozenoxacin 1% cream.  ... with an emphasis on U.S. patients, involved 412 ... older with a clinical diagnosis of bullous or ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
... today announced the national availability and receipt of ... pain medication monitoring program offering the industry,s highest ... and identify potential negative drug interactions before they ... concerns of prescription pain medication abuse by using ...
... ISIS ), the leader in antisense therapeutics, today ... Goldman Sachs 33rd Annual Global Healthcare Conference on Tuesday, June ... in Rancho Palos Verdes, CA. A live audio ... & Media" section of the Company,s Web site, www.isispharm.com ...
Cached Medicine Technology:PeaceHealth Laboratories' New Patent Addresses a Leading Cause of Death: Prescription Drug Abuse 2
The Leica M500 OH3 is an advanced surgical microscope used by neurosurgeons. It is a smart system combining the best optical performance available on the market with an innovative and unique stand....
Surgical Loupes...
... MAGNETOM Allegra is the ultimate brain ... been optimized for best image quality ... all in a highly compact design. ... diagnosing stroke, epilepsy, tumor and multiple ...
Signa Profile is built on the Signa foundation to deliver speed & image quality....
Medicine Products: