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OHSU research team joins elite consortium dedicated to curing type 1 diabetes
Date:9/15/2010

PORTLAND, Ore. -- Oregon Health & Science University's Markus Grompe, M.D., will lead a multi-center team of scientists selected to participate in the prestigious Beta Cell Biology Consortium (BCBC). Funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the consortium's long-term goal is to develop a cell-based therapy for insulin delivery in type 1 diabetes patients.

"The goal of our work is to produce abundant quantities of functional human insulin-producing beta cells that can be used for transplantation to cure patients with type 1 diabetes. Our group in particular is focused on novel sources for transplantable beta cell replacements," said Grompe, principal investigator and director of the Pap Family Pediatric Research Institute, OHSU Doernbecher Children's Hospital; and director of the Oregon Stem Cell Center at OHSU.

Type 1 diabetes, formerly called juvenile diabetes, is characterized by a lack of insulin that results from the destruction of the insulin-producing beta cells of the pancreas. Without insulin, the body cannot process the glucose it receives from food and requires for energy. People with type 1 diabetes must take insulin every day, either by injection or continuously through a pump. To ensure they are receiving the proper amount, they frequently test their blood-glucose levels, which requires multiple finger pricks throughout the day.

"It is our hope that through the work of this interactive consortium, we can eliminate the need for this painful, lifelong ritual," said Grompe.

Grompe is a nationally accomplished stem cell and gene therapy expert. His pioneering work on liver stem cells and liver regeneration medicine provided a natural segue to this line of research. Recent studies by Grompe, BCBC project co-investigator Philip Streeter, Ph.D., and others indicate adult liver cells can successfully be converted into insulin-producing beta cells through genetic reprogramming in a m
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Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

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