Navigation Links
OHSU research suggests new strategy for protecting aging Americans against infectious disease
Date:12/17/2007

PORTLAND, Ore. Researchers at Oregon Health & Science University have uncovered new information about the bodys immune system in a study that suggests new strategies may be in order for protecting the countrys aging population against disease. The research is published in the current edition of the Proceedings of the National Academy of Science.

The research focused on an important component of the bodys immune system, a certain type of white blood cell called nave T-cells. These cells are called naive because they have no experience of encountering germs. However, once they encounter germs, they learn and adapt to become strong defenders of the organism. The cells play an important role in the vaccination process because vaccines, which contain either weakened or dead viruses, teach nave T-cells how to recognize germs and prepare the body for fighting infectious diseases at a later date. Previous research shows that an individuals supply of nave T-cells diminishes over their lifetime, meaning that in old age a person is more susceptible to infections such as the flu.

Our research identified one actual process by which nave T-cells are lost later in life, explained Janko Nikolich-Zugich, Ph.D., a senior scientist at the OHSU Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center and a professor of molecular microbiology and immunology in the OHSU School of Medicine.

Throughout our lives, nave T-cells divide very slowly in our bodies. This helps maintain sufficient numbers of nave T-cells while we are young. As we age, nave T-cells are lost and the remaining ones speed up their division to make up for the losses in their numbers. Interestingly, after a certain point, this actually causes the numbers of nave T-cells to dwindle over time. Our data shows that once the number of nave T-cells drops below a critical point, the rapidly dividing nave cells are very short lived. Based on this finding and other information, research suggests that some of the aging Americans may be better protected against disease by finding a way to jumpstart production of new nave T-cells instead of through revaccination.

Nikolich-Zugich and his colleagues are now working on methods to encourage the body to restart production of nave T-cells.

Even a slight boost in the number of these important T-cells could protect an aging person against disease for several years, explained Nikolich-Zugich.


'/>"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 05, 2016 , ... The talus is the part ankle ... falls, or traffic accidents can cause the talus bone to be fractured, and a ... In a first-of-its-kind procedure using 3D printing technology, internationally renowned orthopedic surgeon Dr. ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... announces the Everlasting Glove, a sports invention that aids in the improvement of ... Manufacturing industry is worth $9 billion," says Scott Cooper, CEO and Creative Director ...
(Date:5/4/2016)... ... 2016 , ... Trinity Health today launched its inaugural Innovation ... at improving care and reducing readmission rates for patients who are dually eligible ... is to drive innovation that transforms our ministry and our industry to be ...
(Date:5/4/2016)... AZ (PRWEB) , ... May 04, 2016 , ... ... Annual Technology & Business Conference. The conference opened on Tuesday with Frank Luntz, ... discussion on NCPDP’s PDMP Solution provided a deep dive on NCPDP’s model solution ...
(Date:5/4/2016)... , ... May 04, 2016 , ... Level 10 Head ... her verbal commitment to the University of Arizona for the fall of 2019. ... decision last month. Brovedani’s commitment to the GymCats came from her connection with the ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016 According ... Size, Share, Development, Growth and Demand Forecast to 2022 ... Field Strength (High Field, Very High Field, Low to ... Head and Neck, Spine, Musculoskeletal, Vascular, Breast, Pelvic and ... magnetic resonance imaging (MRI) market was valued at $5,351.7 ...
(Date:5/3/2016)... 3, 2016 Norgine ... sie einen entscheidenden Meilenstein durch diese Veröffentlichung ... zum Handeln, um Patientenresultate  bei Verdauungs- und ... Fortschritten im Verständnis der Hepatischen Enzephalopathie bei ... für Hepatische Enzephalopathie in der Öffentlichkeit zu ...
(Date:5/2/2016)... , May 2, 2016  Celsion Corporation (NASDAQ: ... today announced data from the first cohort of ... trial (the OVATION Study) combining GEN-1, the Company,s ... the treatment of newly-diagnosed patients with advanced ovarian ... interval debulking surgery.  In the first three patients ...
Breaking Medicine Technology: