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OHSU joins forces with UO, Harvard to accelerate Fanconi anemia research
Date:5/27/2010

PORTLAND, Ore. Oregon Health & Science University is partnering with the University of Oregon and Harvard Medical School to expedite basic science research into new and existing drugs and compounds that may prevent the complications associated with Fanconi anemia, an inherited condition that can lead to bone marrow failure and cancer.

With a new $10.7 million grant from the National Heart Lung and Blood Institute, a branch of the NIH, the research teams will screen and sort thousands of drug candidates in mice at OHSU, zebra fish at UO and human cell lines at Harvard.

Approximately 1,000 of the drug candidates to be screened already have been approved by the FDA to treat other medical conditions, which could expedite their application in Fanconi anemia. Another 10,000 molecules with similar properties, but randomly modified for various biological reactions, also will be screened for therapeutic benefits.

"This generous NIH grant coupled with our long-running association with the Fanconi Anemia Research Fund will allow us to quite literally pursue the bench-to-bedside vision of turning fundamental basic research into therapies we can use with patients. This project highlights the value of integrative collaboration," said Markus Grompe, M.D., principal investigator and director of the OHSU Pap Family Pediatric Research Institute, and professor of pediatrics, OHSU Doernbecher Children's Hospital.

Some of the potential drugs candidates were first identified at a Fanconi Anemia Research Fund workshop in Portland. The fund founded by former UO President Dave Frohnmayer and his wife, Lynn, who have lost two daughters to the disease provided nearly $650,000 to pursue ideas developed at the workshop.

"This NIH grant will expand and hasten the efforts of this large collaborative effort to identify new therapies for Fanconi anemia patients," said Lynn Frohnmayer. "The projects involved in this grant have direct implications
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Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

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