Navigation Links
OHSU cancer institute researcher discovers new predictor of prostate cancer recurrence
Date:2/14/2008

PORTLAND, Ore. An Oregon Health & Science University Cancer Institute researcher has found a biomarker that may help improve the ability to predict if a mans prostate cancer is going to come back after surgical removal.

In order to make this discovery, researchers examined prostate cancer tissue samples that had been removed during surgical procedures on cancer patients. The researchers found that men whose tumors showed a silencing of the gene CDH13 had a five-fold increased risk of prostate cancer recurrence compared with men whose tumors showed no silencing of this gene, according to Joshi Alumkal, M.D., OHSU Cancer Institute member and assistant professor of medicine, (hematology/medical oncology), OHSU School of Medicine. In normal cells, this gene is active, but in some cancer cells it may be turned off, which leads to a propensity for metastasis, or spreading.

The research, DNA Methylation as a Predictor of Prostate Cancer Recurrence, will be presented as a poster on Thursday, Feb. 14, from 11:30 a.m. to 12:30 p.m. at the 2008 American Society of Clinical Oncology Genitourinary Symposium in San Francisco.

In this study, the largest of its kind examining DNA methylation changes and prostate cancer recurrence, the research team looked at tissue samples from 151 research subjects with localized prostate cancer with at least five years of follow-up after their prostatectomies. During prostate cancer formation, the DNA may be modified through a process called DNA methylation, which turns off many important genes called tumor suppressor genes that act as the brakes on cancer cell growth or cancer cell spread. CDH13 is a prime example of one of these genes.

Two-thirds of the subjects were free of recurrence; one-third had a recurrence.

In the clinic, those of us who care for patients with prostate cancer look at the pathology report and PSA blood test to determine how a patient will do after surgery and how aggr
'/>"/>

Contact: Christine Decker
deckerch@ohsu.edu
503-494-6397
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. DDT Compound Speeds Breast Cancer Growth
2. Secretary Norman Y. Mineta Joins Lung Cancer Alliance Board of Directors
3. The Facts African Americans Need to Know About Colon Cancer
4. How DDT metabolite disrupts breast cancer cells
5. Climb to Fight Breast Cancer Offers Peaks for Every Skill Level
6. Patient with rare disorder responds to cancer drug
7. Cancer Drug Works Against MS in Early Trial
8. American Cancer Society honors exemplary cancer caregivers
9. Smokers might benefit from earlier colon cancer screening
10. Scientists solve structure of gene regulator that plays key role in cancer
11. Sun Busters(R) Now Sports The Skin Cancer Foundations Seal of Recommendation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... ... Super Bowl 50 will emanate from Levi’s Stadium in Santa Clara, CA on Sunday, ... Bowl. In the two weeks that separate the conference championships and the Super Bowl, there ... game will mark the 50th time it has been held and the festivities will take ...
(Date:7/31/2015)... ... 2015 , ... Precision Aesthetics is New York’s only Thermage skin tightening pinnacle ... provider of Exilis non-surgical fat reduction in New York. Due to its unparalleled ... International clientele. Many patients travel to New York to get their non-surgical skin ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... new store run by GoodThreads. The store can be accessed by visiting ... many of which are customizable. The best part: whenever a product is purchased, ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Sculpted Contours Luxury ... CoolSmooth PRO this week. Zeltiq Aesthetics released this new applicator in the United ... 2014 for treating the outer thighs. The original applicator required a 2 hour ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug ... new True North Conference Center. The medical community, social workers, law enforcement, and ... be more aligned in the effort to better understand and combat sex trafficking. ...
Breaking Medicine News(10 mins):Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... ... the Pederson Immigration Law Group, P.C. is slated to be keynote speaker at this ... ... - The Pederson Immigration Law Group, P.C., (PILG) announced that Jan Pederson, the nation,s ...
... (July 14, 2009) New research published in the July ... Surgeons reveals that African Americans with gastrointestinal stromal tumors ... the gastrointestinal tract, now have survival rates equivalent to those ... to develop GIST and less likely to undergo surgical treatment ...
... , KUALA LUMPUR, Malaysia, July 14 ... wellbeing from ancient Malaysian culture, will be revealed to a global ... a new book, Health and Beauty from the Rainforest: Malaysian ... inspired by these traditions. A lifestyle approach to wellness, ramuan ...
... , , MINNEAPOLIS, July 14 ... advised Biotel that it is terminating the Merger Agreement with ... terms of the agreement. Biotel believes it has complied with ... merit and inconsistent with CardioNet,s representations to Biotel. Biotel is ...
... ROCHESTER, Minn. -- A new Mayo Clinic study ... is better at predicting who will develop Alzheimer,s ... more piece of information to aid in the identification and ... This study will be presented at the Alzheimer,s Association International ...
... CHICAGO, July 14 Continuing its efforts to educate, ... a not-for-profit patient-focused organization, is hosting its 25-minute live call-in ... Monday, July 20, 2009 at 6:00 PM on Channel 21. ... program will feature a frank discussion about women,s health with ...
Cached Medicine News:Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 2Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 3Health News:Study finds survival rates from gastrointestinal tumors improving among African-Americans 2Health News:U.S. Debut: Holistic Health And Beauty From The Rainforest - New Book Reveals Closely Guarded Malaysian Health and Beauty Secrets Introducing the World to Time-Honored Tradition of Ramuan 2Health News:U.S. Debut: Holistic Health And Beauty From The Rainforest - New Book Reveals Closely Guarded Malaysian Health and Beauty Secrets Introducing the World to Time-Honored Tradition of Ramuan 3Health News:Mayo Clinic study continues to refine most effective methods to predict Alzheimer's disease 2Health News:Women's Health - An Intimate Discussion 2
(Date:7/30/2015)... OAKS, Calif., July 30, 2015  Amgen (NASDAQ: ... the second quarter of 2015. Key results include: ... the second quarter of 2014 to $5,370 million, ... by Enbrel ® (etanercept), Prolia ® ... (carfilzomib) and XGEVA ® (denosumab). Unfavorable changes ...
(Date:7/30/2015)... , July 30, 2015  Amgen (NASDAQ: AMGN ) ... and managing director of Warburg Pincus LLC, to the Amgen ... welcome Fred Hassan and the deep, global experience ... said Robert A. Bradway , chairman and chief executive ... innovation will serve Amgen well." Mr. Hassan has ...
(Date:7/30/2015)... 30, 2015  Cleveland Clinic President Wael Barsoum ... last month that industry is compelled to adopt declining ... the efficiencies—and develop the transformational innovations -- required to ... were preceded by Doug Kohrs , past President ... who stressed that industry must add "episode of care," ...
Breaking Medicine Technology:Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... bill in Pennsylvania,s Senate and House of Representatives is ... mail order prescription plans. The legislation allows individuals to ... community pharmacist for the exact same price, which will ... saving and tens of thousands of jobs throughout the ...
... 8, 2011 Skilled Healthcare Group, Inc. (NYSE: ... year ending December 31, 2011.  This new guidance incorporates the ... for Medicare & Medicaid Services (CMS) of its final rule ...  CMS reduced Medicare reimbursement rates for skilled nursing facilities by ...
Cached Medicine Technology:"Prescription for Choice" Easy Pill to Swallow for Pennsylvania 2"Prescription for Choice" Easy Pill to Swallow for Pennsylvania 3Skilled Healthcare Announces Revised 2011 Guidance 2Skilled Healthcare Announces Revised 2011 Guidance 3Skilled Healthcare Announces Revised 2011 Guidance 4Skilled Healthcare Announces Revised 2011 Guidance 5Skilled Healthcare Announces Revised 2011 Guidance 6
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: