OHSU School of Dentistry team discovers new molecule in blood-pressure cont... (. Balkowiec and her team found that ...)

OHSU School of Dentistry team discovers new molecule in blood-pressure control system

Date:1/8/2009

Balkowiec and her team found that the stimulation of baroreceptors, as experienced during an increase in blood pressure, leads to the release of BDNF. The study also discovered that BDNF is present at the central end of baroreceptors in the brainstem.

"In fact, BDNF is likely to play the most important role at the central end of baroreceptors, where they connect to second-order neurons in the blood-pressure control pathway," said Balkowiec. "BDNF has previously been shown to play an important role in establishing neuronal connections in other parts of the nervous system, but this is the first time it has been considered a factor in the blood pressure control system."

Studies under way, in collaboration with Virginia Brooks, Ph.D., OHSU School of Medicine professor of physiology and pharmacology, indicate that levels of BDNF in cardiorespiratory nerve cells increase dramatically when blood pressure rises. This suggests a direct role of BDNF in regulation of blood pressure, said Balkowiec.

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Contact: Sydney Clevenger
clevenge@ohsu.edu
503-418-1792
Oregon Health & Science University
Source:Eurekalert

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OHSU School of Dentistry team discovers new molecule in blood-pressure cont...(. Balkowiec and her team found that ...),Health