Navigation Links
OHSU School of Dentistry team discovers new molecule in blood-pressure control system
Date:1/8/2009

PORTLAND, Ore. Researchers at Oregon Health & Science University's School of Dentistry (www.ohsu.edu/sod) have discovered that the nerve cells controlling heart rate and blood pressure synthesize a molecule known to be critically important for proper nervous system growth. The finding could someday play a significant role in the prevention of Sudden Infant Death Syndrome (SIDS) and high blood pressure. According to the National Institutes of Health, SIDS is the leading cause of death in children between 1 month and 1 year of age. About one in three adults in the United States has high blood pressure.

The new discovery was published in a January issue of the Journal of Neurochemistry (vol. 108, pp. 450-464) and released online December 1, 2008 (www3.interscience.wiley.com.liboff.ohsu.edu/cgi-bin/fulltext/121542115/HTMLSTART). The Journal of Neurochemistry is a leading peer-reviewed neuroscience journal-.

"Our discovery sheds light on how the nerve supply to the cardiovascular system is established during development," said Agnieszka Balkowiec, M.D., Ph.D., principal investigator, OHSU School of Dentistry assistant professor of integrative biosciences and OHSU School of Medicine adjunct assistant professor of physiology and pharmacology. "Someday we hope to better understand cardiorespiratory developmental disorders such as SIDS."

Changes in blood pressure are signaled to the brain by nerve cells called baroreceptors. The OHSU study shows that baroreceptors make a molecule called Brain-Derived Neurotrophic Factor (BDNF), which belongs to the family of neurotrophins that play a critical role in the development and plasticity of other nerve cells. (Studies suggest that developmental abnormalities in nerve pathways that control the cardiovascular and respiratory system may result in SIDS).

Balkowiec and her team found that the stimulation of baroreceptors, as experienced during an increase in blood pressure, leads to the release of BDNF. The study also discovered that BDNF is present at the central end of baroreceptors in the brainstem.

"In fact, BDNF is likely to play the most important role at the central end of baroreceptors, where they connect to second-order neurons in the blood-pressure control pathway," said Balkowiec. "BDNF has previously been shown to play an important role in establishing neuronal connections in other parts of the nervous system, but this is the first time it has been considered a factor in the blood pressure control system."

Studies under way, in collaboration with Virginia Brooks, Ph.D., OHSU School of Medicine professor of physiology and pharmacology, indicate that levels of BDNF in cardiorespiratory nerve cells increase dramatically when blood pressure rises. This suggests a direct role of BDNF in regulation of blood pressure, said Balkowiec.


'/>"/>

Contact: Sydney Clevenger
clevenge@ohsu.edu
503-418-1792
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Time to Set Kids Back-to-School Sleep Clocks
2. Add Earlier Bedtime to Back-to-School List
3. Does Pathological Shyness Make for School Shooters?
4. Mailman School of Public Health study examines link between racial discrimination and substance use
5. Survey reveals disparities in skin cancer knowledge, protection among high school students
6. Non-medicinal treatment touted for pre-schoolers with ADHD
7. Nonmedicinal treatment touted for preschoolers with ADHD
8. Obese Children Miss More School Days
9. Back to School Means Backpack Safety
10. Heart Attacks at School Involve More Adults Than Kids
11. Back to School Means Return of School Blood Drives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology: