Navigation Links
OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
Date:5/29/2012

BEAVERTON, Ore. - While vaccines are perhaps medicine's most important success story, there is always room for improvement. Researchers at Oregon Health & Science University's Oregon National Primate Research Center (ONPRC) appear to have done just that. As explained in a newly published research paper, Mark Slifka, Ph.D., and colleagues have discovered a new method for creating vaccines that is thought to be safer and more effective than current approaches. The research results are published online in the journal Nature Medicine.

"Most vaccines have an outstanding safety record," explained Slifka. "It is important to keep in mind that no medical achievement has saved more lives than the simple act of vaccination. However, for many diseases, we have struggled to develop an effective vaccine. In other cases, vaccines may be protective, but come with rare but serious side effects. For instance, the live oral polio vaccine was very effective at stopping polio outbreaks and transmission, but was also responsible for eight to 10 cases of vaccine-associated polio in the United States each year. This problem was solved in 2000 when the U.S. switched to a formaldehyde-fixed 'dead' form of the vaccine. Our goal is to make vaccines like these safer and potentially even more effective by pioneering an entirely new approach to vaccine development."

Slifka's approach is remarkable because it is the first to demonstrate that hydrogen peroxide can inactivate viruses for use as vaccines. Although hydrogen peroxide has long been known as an effective antiseptic and is often used to sterilize medical equipment, it was believed that it would be too damaging to be useful in vaccine development. It turns out that this previous notion was incorrect. In fact, peroxide may turn out to be one of the best new approaches to future vaccine design.

In the study published this week, Slifka's lab generated not one, but three vaccines.

"We wanted to demonstrate that this is truly a platform technology and not just a one-hit-wonder," explained Slifka. "For this reason, we chose three unrelated model systems and demonstrated protective vaccine-induced immunity in all three cases."

The three diseases targeted by these viruses are West Nile virus, Lymphocytic choriomeningitis virus (a relative of lassa fever virus, known to cause hemorrhagic fever in Africa) and vaccinia virus (widely known for its previous use in the smallpox vaccine.)

An Oregon-based biotech company, Najt Technologies, Inc., is hoping that these advances in vaccine technology will result not only in new vaccines but also new jobs in the Portland area.

"This new approach really gives a boost to an area of vaccine development that's been stagnant for some time," said Ian Amanna, Ph.D., associate vice president for research at Najt Technologies.

"Because of these advances, we've been increasing our workforce and putting together a group of very talented researchers. In partnership with OHSU, we're excited to have the opportunity to further develop this technology into commercial vaccines that can offer protection for at-risk individuals. These vaccines will not only be important to international travelers, but also to the people living in endemic regions. These places are often in developing countries with limited resources for preparing and testing life-saving vaccines and we are looking forward to the day that we can bring these new vaccines to the countries that need them the most."

Najt Technologies, founded by Slifka and colleagues using methods first discovered at OHSU, hopes to continue working together with academic institutions such as OHSU, ONPRC, and Washington University-St. Louis to create new and better vaccines for some of the world's biggest problems including West Nile virus, yellow fever and dengue hemorrhagic fever.


'/>"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-4158
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Researchers at Oregon Health & Science University discover MS-like disease in monkeys
2. Study finds most Oregon hospices do not fully participate in the Death with Dignity Act
3. Relax for Hope May 23 - a Spa Day Fundraiser for the American Cancer Soiety's Relay for Life in Lincoln City, Oregon.
4. Phoseon Technology Selected as Finalist for 2010 TechAmerica Oregon Technology Awards
5. Despite much-higher poverty rates, rural Oregonians use less public assistance
6. State of Oregon Department of Human Services Selects Netsmart Technologies for Comprehensive Behavioral Healthcare Integration Project
7. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
8. Boston researcher, surgical oncologist receives national award
9. National initiative launched to change the way biology departments approach undergraduate education
10. Georgetown physician leads national resveratrol study for Alzheimers disease
11. Dr. Yael Mosse will receive first Nachman Award in Pediatric Oncology at national conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Medic CE , ... Surprising Truth about Pediatric Septic Shock” hosted by the Journal of Emergency Medical Services ... p.m. Eastern time, will be presented by Captain Rommie Duckworth, LP, a career fire ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... offering holistic pediatric dentistry options for its patients on Long Island, New York. ... entire physical well being, and is one of the biggest trends in dentistry ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., ... for the food and beverage industry offers Citri-Fi®, a natural citrus fiber, to ... purchasing decision process. As a result, labels need to deliver simple, transparent and ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... Population Health and Clinical Integration company, announced today that its iClinic V12.2 solution ... (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which emphasize team-based ...
(Date:5/23/2017)... ... May 23, 2017 , ... PM360, the premier information ... announced the winners of its 3rd Annual ELITE Awards. The ELITE (Exceptional • ... the healthcare industry today. , Out of more than 500 submissions, 100 winners ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
(Date:5/4/2017)... , May 4, 2017  Fortuna Fix Inc. (" ... to be the first to eliminate the need for embryonic ... cells to treat neurodegenerative diseases. Fortuna ... with Professor Michael Fehlings , MD, PhD; Father ... , MD, MPH; and Professor James Giordano , PhD. ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 ... 2017 Annual Clinical and Scientific Meeting— OBP Medical , ... devices, today announced the launch of a new extra-small ... and ER-SPEC vaginal specula. Already available ... and extra-large sizes makes OBP Medical,s line of single-use ...
Breaking Medicine Technology: