Navigation Links
OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
Date:7/23/2010

PORTLAND, Ore. Oregon Health & Science University Knight Cancer Institute researchers found that the GRB7 gene drives an aggressive form of breast cancer and acts independently of the HER-2 gene, known to be a stimulator of breast cancer growth. Isolating the role of this gene could ultimately help fine-tune a patient's treatment and enable physicians to provide a more accurate prognosis.

The study, published online this month by Breast Cancer Research and Treatment, established that levels of GRB7, or growth factor receptor bound protein seven, are important on their own as a marker for aggressive breast cancer. Previously it was understood that patients whose breast cancer tumors tested positive for high levels of HER-2, the protein human epidermal growth factor receptor-2, tended to have a more aggressive form of the disease than patients whose tumors did not have elevated levels of this protein. However, OHSU Knight Cancer Institute researchers found that the protein driving this aggressive form of the disease is GRB7 rather than HER-2 on its own.

"Our work shows GRB7 protein levels are an important and independent factor in determining a prognosis for breast cancer," said OHSU Knight Cancer Institute member Shiuh-Wen Luoh, M.D., Ph.D., assistant professor of medicine in the Division of Hematology and Medical Oncology, medical oncology director for the Comprehensive Breast Cancer Clinic and senior author of the paper.

The findings could have implications for the types of therapies used. Luoh said a next step will be to determine if high levels of the GRB7 protein influence patient responses to anti-HER-2 therapies such as Herceptin or Tykerb.

The research into GRB7's role is advancing the OHSU Knight Cancer Institute's mission to provide cancer patients with personalized treatments that target the specific characteristics of their disease.

"Our work was only made possible with the availability of a breast tumor repository that OHSU and the Knight Cancer Institute began collecting about 20 years ago," said Ed Keenan, Ph.D., who served as co-investigator on the study. Keenan, former associate dean of medical education for OHSU's School of Medicine, is a professor in the Department of Physiology and Pharmacology and the Department of Surgery. He also serves as president of The Foundation for Medical Excellence.


'/>"/>

Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... For breast cancer clinicians ... (SABCS) or those who desire a more intimate review and analysis of its highlights, ... Bench to Bedside—is being offered by Imedex on February 4, 2017 in Chicago. Chaired ...
(Date:1/17/2017)... ... 17, 2017 , ... Healthful Balance announces the national release ... operated by Ed Stroup, was created to offer the highest quality vitamins and ... customer service. Healthful Balance products can be purchased online through their website, or ...
(Date:1/17/2017)... ... January 17, 2017 , ... Kevin Harrington (one of the ... be featuring DRTV campaigns regarding the topic of Beauty and Personal Care. ... of themselves. What better way to commit to these changes than beginning with personal ...
(Date:1/17/2017)... Florida (PRWEB) , ... January 17, 2017 , ... ... City, a new 21st century approach to infusing high speed technology into the ... area exclusively dedicated to the advancement of healthcare and wellness in a yet-to-be-named, ...
(Date:1/17/2017)... ... January 17, 2017 , ... Mirror Mirror Beauty Boutique, Houston’s premiere ... Diamond Level in Zeltiq’s Crystal Rewards Program. Practice founder, Paul Vitenas, MD FACS, is ... of providers. , Produced by Zeltiq, CoolSculpting is approved by the Food and ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 2017  Pennsylvania Secretary of Health Dr. ... marijuana growers/processors and dispensaries are now available on ... Permit applications will be accepted from February 20 ... an important step forward in getting this valuable ... Murphy said. "We,ve developed a thorough application that ...
(Date:1/17/2017)... 17, 2017  Edwards Lifesciences Corporation (NYSE: ... structural heart disease and critical care monitoring, plans to ... 31, 2016 after the market closes on Wednesday, February ... 5:00 p.m. ET that day to discuss those results. ... (877) 407-8037 or (201) 689-8037.  For 72 hours following ...
(Date:1/17/2017)... 2017  Market Research Future published a Half Cooked Research Report ... to reach USD 33.6 million during the period 2016 to 2022 ... ... Market has been examined as a swiftly growing market and expected ... for endoscopy device in various regions.  The increasing growth in endoscopy ...
Breaking Medicine Technology: