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OHSU Cancer Instutute researchers find abnormalities in gene for melanoma
Date:5/29/2008

PORTLAND, Ore. New research from the Oregon Health & Science University Cancer Institute about mutations in melanoma may bring a wellspring of hope to many patients.

Researchers have discovered that there are several different kinds of DNA abnormalities that can occur in a gene called the KIT gene. These abnormalities are associated with different kinds of acral and mucosal melanomas, which are less common, but highly malignant forms of skin cancer. Acral melanomas are found on the palms of hands, the soles of feet and under nails. Mucosal melanomas are found in the mucous membranes of some organs of the body.

If scientists can figure out the mutation, effective treatments can follow, explained Michael Heinrich, M.D., co-principal investigator, OHSU Cancer Institute member and head of the Hematology and Medical Oncology Section at the Portland Veterans Affairs Medical Center. The co-investigator is Christopher Corless, M.D., Ph.D., OHSU Cancer Institute member.

The research will be presented Sunday, June 1, at 5 p.m. during the annual American Society of Clinical Oncology in Chicago.

This study builds on recent research about the first instance in which a womans metastatic melanoma was driven into remission by the targeted therapy drug, Gleevec, which was developed at the OHSU Cancer Institute. Previously there had been few effective treatments for melanoma patients with metastatic disease. But not all melanomas respond so successfully to Gleevec.

In the current study, Heinrich and colleagues studied 129 samples gathered from people with different types of melanoma and found that there is a high rate of mutations in these cancers.

This means that if we can find the melanoma early, it can be screened to see what type of mutations are present, and eventually you can get the right medication or treatment, Heinrich said.

Heinrich explained that it is similar to testing of breast cancer tumors to decide if patients should receive s
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Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

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