Navigation Links
OHSU Cancer Institute researchers pinpoint how smoking causes cancer
Date:5/13/2008

PORTLAND, Ore. Oregon Health & Science University Cancer Institute researchers have pinpointed the protein that can lead to genetic changes that cause lung cancer.

The research will be published Tuesday, May 12, in the British Journal of Cancer.

Researchers discovered that the production of a protein called FANCD2 is slowed when lung cells are exposed to cigarette smoke. Low levels of FANCD2 leads to DNA damage, triggering cancer. Cigarette smoke curbs the production of caretaker proteins, like FANCD2, which normally prevent cancer by fixing damages in DNA and causing faulty cells to commit suicide.

Research has shown that smoking is strongly linked to lung cancer, but this discovery may help scientists improve treatments for lung disease in the future.

These findings show the important role FANCD2 plays in protecting lung cells against cigarette smoke, and may explain why cigarette smoke is so toxic to these cells, said lead author Laura Hays, Ph.D., research assistant professor of medicine (hematology/medical oncology) and member of the OHSU Cancer Institute.

Senior author, Grover Bagby, M.D., further stated that: Dr. Hays work shows that FANCD2 is an important protein in protecting against cancer, and cigarette smoke knocks out its production. Although there are probably other proteins involved in this process, we know this is a key one because cells with very high levels of FANCD2 were resistant to the toxic effects of the smoke. Bagby is the founding and past director of the OHSU Cancer Institute and professor at the Northwest Cancer Veterans Affairs Research Center at the Portland Veterans Affairs Medical Center.

The authors created an artificial windpipe in the lab to replicate the environment of a smokers lung. They then studied the effects of cigarette smoke on different proteins in cells and found that FANCD2 levels were low enough to allow DNA damage.

FANCD2 is part of a family of proteins involved in an inherited condition called Fanconi anemia. People with the condition are more likely to develop cancers at a young age and have low levels of these proteins.

Lesley Walker, Ph.D., director of cancer information at Cancer Research UK, said: This interesting piece of science adds to our understanding of why smoking is so deadly. Smoking is the single biggest preventable cause of cancer and causes nine out of 10 cases of lung cancer.

But the good news is that quitting works after five years without smoking, your risk of a heart attack will have fallen to half that of a smoker. And after 10 years, your risk of lung cancer will have halved too.

Lung cancer is the most common cancer in the world, with 1.3 million people diagnosed every year.


'/>"/>

Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Vitamin D protects cells from stress that can lead to cancer
2. Surviving breast cancer is not enough, warns Breast Cancer Campaign
3. HPV linked to better survival in tonsil, tongue cancer, U-M study finds
4. End-stage dementia patients deserve the same access to palliative care as people with cancer
5. FDA Says, Wait To Dying Men; Coast-To-Coast Prostate Cancer Demonstrations on May 30th in Protest of FDA Failure to Approve Safe, Effective Immunotherapy
6. Newer Prostate Cancer Treatment Similar to Traditional Surgery
7. Mood Disorders Put Breast Cancer Patients at Risk for PTSD
8. Acrylamide Raises Kidney Cancer Risk
9. HRSA Outreach Seeks to Raise Cancer Awareness Among People Who Lived Near Nuclear Sites or Mined Uranium
10. Dr. Lance H. Brown President-Elect of Dermatologic Society of Greater New York Fights Misconceptions About Sun Protection and Skin Care in Support of Skin Cancer Awareness Month - May
11. National Lung Cancer Partnership Launches Campaign to Raise Lung Cancer Awareness Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... Chicago, Illinois (PRWEB) , ... February 05, 2016 ... ... advisors and independent PROSHRED franchises from across the country gathered at the La ... to recognize top performers. PROSHRED Chicago was named the year’s most outstanding ...
(Date:2/5/2016)... ... 2016 , ... Pivot Point Consulting, a leading national Healthcare ... Services for HIT Implementation Support & Staffing report with an outstanding score of ... healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 clinics. , ...
(Date:2/5/2016)... ... ... Colorize is a web theme package created exclusively for Final ... dynamic moving camera. Colorize is perfect for personal and web related videos and its ... to 5 focus points per scene, stage floor scene presets that are great for ...
(Date:2/5/2016)... Russia (PRWEB) , ... February 05, 2016 , ... Calls ... has a completely new user interface design and the developer has fixed known bugs ... those they want to on their phone while not consuming any of their device’s ...
(Date:2/4/2016)... , ... February 04, 2016 , ... ... "It's All About YOU Re-Treat" on February 19-21, 2016, in Southern California . ... Rancho Palos Verdes, California. These 30 professional speakers, including Clinical Psychologist and Hypnotherapist ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016   Bernstein Liebhard LLP today ... the United States District Court for the District of ... "Class") consisting of all persons or entities who purchased common ... INSY ) from March 3, 2015 through January 25, ... of its officers with violations of the Securities Exchange Act ...
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary Breast ... cancer and the most common cancer in women worldwide, ... disease exceedingly prevalent. The number of women diagnosed with ... but the number of deaths has declined due to ... treatment has been revolutionized in the past four decades, ...
Breaking Medicine Technology: