Navigation Links
OHSU Cancer Institute researcher discovers what fuels certain cancer mutation

ATLANTA An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer.

Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Monday, Dec. 10, at 3:30 p.m.

Polycythemia vera is a disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. There is no cure.

Mice with normal TNF-alpha production and the JAK2 mutation developed the red blood cell disease very quickly within two to three weeks. The blood became very thick, and they developed severe bone marrow fibrosis, excessive fibers in the bone marrow with a decrease in healthy cells. In contrast, mice without the hormone but carrying the JAK2 mutation had normal red blood cell levels and normal bone marrow.

The hormone, TNF-alpha is known as a highly potent hormone, but until now its role in cancer has not been well understood.

If these specific hormones are understood, then there is hope to find a new way to fight these cancer cells by attacking the specific hormones triggering the cancer cells, said Bumm, a fellow in hematology/ medical oncology, OHSU School of Medicine.

There are already drugs developed that target TNF-alpha used for patients with auto immune and inflammatory diseases such as rheumatoid arthritis. But the drugs have not been used for cancer patients. Bumm said one of the next steps will be to conduct studies on a larger mouse study and also testing these different drugs effect on this JAK2-induced cancer.

Maybe one of these drugs will work on the mice and is safe so that we could begin testing the drugs on patients. At this point, there is no specific treatment for polycythemia vera cancer patients. Maybe we opened a new door to understand leukemia better and to fight it at a crucial root, Bumm said.

Polycythemia vera is rare, about five in every 1 million people have it. Without treatment, about half the people who have polycythemia vera with symptoms die in less than two years.

Often, people with polycythemia vera have no symptoms for years. The earliest symptoms usually are weakness, fatigue, headache, light-headedness, shortness of breath and night sweats. Vision may be distorted, and a person may have blind spots or may see flashes of light. Bleeding from the gums and more bleeding than would be expected from small cuts are common. The skin, especially the face, may look red. A person may itch all over, particularly after bathing or showering.


Contact: Christine Decker
Oregon Health & Science University

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... It’s inevitable that everyone will ... close friend, or animal pass away, death lives among us. It is your perspective, ... from a family of 11 children, author T Sky understands that she may see ...
(Date:11/30/2015)... ... November 30, 2015 , ... Vasont Systems, a ... Universal Integrator (VUI) extension unites with Syncro Soft’s latest software update, oXygen XML ... continuous process with the latest release of oXygen® XML editor and the Vasont® ...
(Date:11/30/2015)... ... 2015 , ... GKhair & Tibolli team members and artists were excited and ... November 8th and 9th at the Puerto Rico Convention Center, San Juan Puerto Rico. ... top of the line fashion journalists. The San Juan Beauty Show carries immense credibility ...
(Date:11/30/2015)... CHICAGO, IL November 30, 2015 (PRWEB) , ... ... ... SpeechCheck and Winscribe are pleased to announce their strategic partnership at ... speech recognition consultants, SpeechCheck, Inc., and Winscribe, global providers of cutting-edge dictation ...
(Date:11/30/2015)... ... November 30, 2015 , ... CTI Group ... which empower organizations through communication analytics, announced today that their Proteus® VoIP QMS ... their service quality. , Proteus® VoIP QMS (Quality Management System) does ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Elbit Imaging Ltd. (TASE, NASDAQ: ... that it was informed by InSightec Ltd. ("InSightec"), that the ... approved its Exablate Neuro system to treat movement, pain ... --> Insightec,s Exablate Neuro platform is transforming medicine ... technologies: Focused Ultrasound, which is used to lesion the ...
(Date:11/29/2015)... 29, 2015   Royal Philips  (NYSE: PHG, AEX: ... at the 2015 Radiological Society of North America Annual ... Place in Chicago . Visitors to ... company,s broad portfolio of integrated Diagnostic Imaging, Clinical Informatics, ... clinical performance, improve workflow and create a superior patient ...
(Date:11/29/2015)... , Nov. 29, 2015 CIVCO Medical ... technology at the Radiological Society of ... Chicago November 29 – December ... designed to offer customers unrivaled versatility, enhanced user ... --> ...
Breaking Medicine Technology: