Navigation Links
OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
Date:12/10/2007

ATLANTA An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer.

Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Monday, Dec. 10, at 3:30 p.m.

Polycythemia vera is a disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. There is no cure.

Mice with normal TNF-alpha production and the JAK2 mutation developed the red blood cell disease very quickly within two to three weeks. The blood became very thick, and they developed severe bone marrow fibrosis, excessive fibers in the bone marrow with a decrease in healthy cells. In contrast, mice without the hormone but carrying the JAK2 mutation had normal red blood cell levels and normal bone marrow.

The hormone, TNF-alpha is known as a highly potent hormone, but until now its role in cancer has not been well understood.

If these specific hormones are understood, then there is hope to find a new way to fight these cancer cells by attacking the specific hormones triggering the cancer cells, said Bumm, a fellow in hematology/ medical oncology, OHSU School of Medicine.

There are already drugs developed that target TNF-alpha used for patients with auto immune and inflammatory diseases such as rheumatoid arthritis. But the drugs have not been used for cancer patients. Bumm said one of the next steps will be to conduct studies on a larger mouse study and also testing these different drugs effect on this JAK2-induced cancer.

Maybe one of these drugs will work on the mice and is safe so that we could begin testing the drugs on patients. At this point, there is no specific treatment for polycythemia vera cancer patients. Maybe we opened a new door to understand leukemia better and to fight it at a crucial root, Bumm said.

Polycythemia vera is rare, about five in every 1 million people have it. Without treatment, about half the people who have polycythemia vera with symptoms die in less than two years.

Often, people with polycythemia vera have no symptoms for years. The earliest symptoms usually are weakness, fatigue, headache, light-headedness, shortness of breath and night sweats. Vision may be distorted, and a person may have blind spots or may see flashes of light. Bleeding from the gums and more bleeding than would be expected from small cuts are common. The skin, especially the face, may look red. A person may itch all over, particularly after bathing or showering.


'/>"/>

Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
Breaking Medicine Technology: