Navigation Links
OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
Date:12/10/2007

ATLANTA An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer.

Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Monday, Dec. 10, at 3:30 p.m.

Polycythemia vera is a disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. There is no cure.

Mice with normal TNF-alpha production and the JAK2 mutation developed the red blood cell disease very quickly within two to three weeks. The blood became very thick, and they developed severe bone marrow fibrosis, excessive fibers in the bone marrow with a decrease in healthy cells. In contrast, mice without the hormone but carrying the JAK2 mutation had normal red blood cell levels and normal bone marrow.

The hormone, TNF-alpha is known as a highly potent hormone, but until now its role in cancer has not been well understood.

If these specific hormones are understood, then there is hope to find a new way to fight these cancer cells by attacking the specific hormones triggering the cancer cells, said Bumm, a fellow in hematology/ medical oncology, OHSU School of Medicine.

There are already drugs developed that target TNF-alpha used for patients with auto immune and inflammatory diseases such as rheumatoid arthritis. But the drugs have not been used for cancer patients. Bumm said one of the next steps will be to conduct studies on a larger mouse study and also testing these different drugs effect on this JAK2-induced cancer.

M
'/>"/>

Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014 Carson Hearing Care has ... hearing health care tips to local residents on a ... will offer weekly articles from the audiologists at Carson ... the latest advances in hearing restoration research, new tinnitus ... audiologists plan to write a new post on the ...
(Date:8/29/2014)... NEW YORK August 29, 2014 - Despite US ... obesity, there are many barriers, several of which may ... study by researchers at NYU Langone Medical Center published ... General Internal Medicine ( JGIM ). , David ... Department of Internal Medicine at NYU Langone, and colleagues ...
(Date:8/29/2014)... IL (PRWEB) August 29, 2014 ... poised to begin accepting applications next month for ... are transitioning into accepting marijuana as a legalized ... and dispensaries will be permitted to operate in ... communities will be best suited to handle legal ...
(Date:8/29/2014)... August 29, 2014 The microbiology testing ... the in-vitro diagnostics industry; it is also the hugest ... driven by the ongoing spread of AIDS – still ... associated with the upsurge of opportunistic infections (OIs); bioterrorism ... broader availability of immunosuppressive medicines. Although for certain infections ...
(Date:8/29/2014)... 29, 2014 Floors of hospitals and ... wearing socks. Also, many patients are relegated to lying ... surgery recovery, Alzheimer’s, etc. Two inventors from Perrysburg, Ohio, ... patient safety. , This special pair of socks helps ... keeps patients who are relegated to beds or chairs ...
Breaking Medicine News(10 mins):Health News:Fort Worth Hearing Aid Leader, Carson Hearing Care, Creates Expert Blog to Discuss Important Hearing Healthcare Topics 2Health News:Fort Worth Hearing Aid Leader, Carson Hearing Care, Creates Expert Blog to Discuss Important Hearing Healthcare Topics 3Health News:Options for weight loss your primary care doctor might not know about 2Health News:Medical Marijuana Approaches Legalization in Chicago 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3
... 27 The Ensign,Group, Inc. (Nasdaq: ENSG ... of,skilled nursing, rehabilitative care services and assisted living,companies, ... FBR Capital,Markets 12th Annual Spring Investor Conference on ... York City. Christopher Christensen, CEO, together with Alan,Norman, ...
... E-Connect Statewide to Discuss Successes and Challenges, ... million children,in California experience an emotional or behavioral ... receive adequate treatment. A lack of knowledge,stigma, limited ... and treatment, putting children at risk for school ...
... Healthcare Consulting Team, ANNAPOLIS, Md., May 27 ... leader in the case management field, has joined ... Ms. Craig, architect of the best-in-class caseload,workflow application, ... Mr. Garry Carneal, SHS President and CEO. "Kathy ...
... disease, study says , , TUESDAY, May 27 (HealthDay News) -- ... even in nonsmokers, researchers report. , The findings -- that ... developing lung cancer, regardless of whether he or she ever ... disease, said study author Dr. Ping Yang, of the Mayo ...
... Kevin Hutchinson to Inaugural Board of Managers, ... chief,executive officer, Kevin Hutchinson, has been named an ... LLC, a wholly owned subsidiary of the,American Academy ... consulting services to primary care physicians and health,systems ...
... Calif., May 27 Animal Dermatology Clinic (ADC),Tustin announces ... the new,Member-At-Large on the Executive Board of the American ... ACVD oversees the,operation of and is the decision making ... term. The Member-at-Large position entails Dr.,Muse being a liaison ...
Cached Medicine News:Health News:The Ensign Group to Present at the FBR Capital Markets 12th Annual Spring Investor Conference on May 29th 2Health News:The Ensign Group to Present at the FBR Capital Markets 12th Annual Spring Investor Conference on May 29th 3Health News:Techno-Savvy Public Awareness Campaign Enables Families to Send a Powerful Message About Children's Mental Health 2Health News:Acuity Workflow Solutions(TM) Enhances Medical Case Management Process: 2Health News:Common Genetic Variant Tied to Lung Cancer Risk 2Health News:Common Genetic Variant Tied to Lung Cancer Risk 3Health News:Prematics CEO Joins Initiative to Advance More Coordinated, Connected Health Care 2Health News:Prematics CEO Joins Initiative to Advance More Coordinated, Connected Health Care 3Health News:Animal Dermatology Clinic Tustin Announces Dr. Russell Muse's Appointment as the Member-At-Large for the Executive Board of the American College of Veterinary Dermatology 2
(Date:8/29/2014)... 2014 Diseases largely eradicated in ... returning. Measles was declared eliminated in 2000, yet the ... August 15—the highest incidence in 20 years. In July, ... whooping cough a problem of "epidemic proportions." ... dying from these preventable diseases—in part because some parents ...
(Date:8/29/2014)... , Aug. 29, 2014  In part ... to leverage a hospital pharmacy as a strategic asset, ... national practice leader for Cardinal Health,s Innovation Delivery Solutions ... care can benefit both hospitals and patients. ... only one part of their job in a value-based ...
(Date:8/29/2014)... 29, 2014 Pixcelldata, the innovative ... has announced a major new deal with Dutch based ... pathology expert, Dr. Marius Nap . ... European Congress of Pathology which is taking placing between ... London where Pixcelldata will demonstrate ...
Breaking Medicine Technology:Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2
The Trans-Blot transfer cell, used with the included PowerPac 200 power supply, performs efficient, high-intensity electrophoretic transfers. The Trans-Blot cell offers many advantages....
... for a Range of ... Native Enzyme, High Intensity, ... Faster, Higher-Efficiency Transfers via ... Field-Intensity Transfers with Movable ...
... Includes: Criterion cell for running ... with plate electrodes. A blotter fit ... Criterion precast gel system, the Criterion ... the flexibility of the Trans-Blot system ...
A blotter fit for use with the incredible new Criterion precast gel system, the Criterion blotter combines excellent blotting efficiency with the flexibility of the Trans-Blot system and the ease-of-...
Medicine Products: