Navigation Links
OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
Date:12/9/2007

ATLANTA Oregon Health & Science University Cancer Institute researchers have opened a new window into the roots of chronic myeloid leukemia (CML).

We are looking under the surface of CML to understand better where the cancer is coming from. We have discovered abnormal cells in the early stem cell population in some CML patients, which dont belong to the CML clone. These are abnormal cells that are not part of the CML clone, said Thomas Bumm, M.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Sunday, Dec. 9, at 4:30 p.m.

Bumm was looking into Philadelphia Chromosome-negative stem cells which he and others had thought would look like normal, healthy cells, and have normal chromosomes. (It has been known that the driving force of CML is the Philadelphia Chromosome-positive cancer cells.)

But no, these chromosome negative cells are not normal looking. We are seeing that there are other abnormal cells in the early stem cell population in the bone marrow of some CML patients that are Philadelphia Chromosome-negative. They have abnormalities such as the deletion of chromosome 7 or a duplication of chromosome 8, explained Bumm, a fellow in hematology/medical oncology, OHSU School of Medicine.

It is not known why patients with CML have these abnormal cells and to what extent. These newly discovered abnormal cells are also seen in other cancers such as myelodysplastic syndrome.

We are not yet sure about the extent of this problem. We do hope though that our studies into the stem cell compartment of CML patients might help to find new targets for CML therapy to cure this cancer, Bumm said.

Chronic myelogenous leukemia is a form of blood cancer characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.

The next step, although costly, will be to analyze more leukemia patients as well as healthy bone marrow samples to continue to look for these new abnormalities.


'/>"/>

Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Fire Door ... provide one resource, from start to finish, for Life Safety compliance. These ... Condition surveys requested by the Joint Commission, and fire stopping reviews, inspections, and ...
(Date:5/24/2016)... ... 2016 , ... United Benefit Advisors (UBA), the nation’s leading ... & Co., Inc. Headquartered in Albany, New York, Austin & Co., Inc. ... and beyond. As an employee-owned company celebrating over 160 years of service, ...
(Date:5/24/2016)... ... May 24, 2016 , ... How to Write Error Free Procedures, **Presented by ... , Human error is known to be the major cause of quality and production ... totally eliminated, many human performance problems can be prevented. , How to Write Error ...
(Date:5/24/2016)... ... (PRWEB) May 24, 2016 -- ... of its Advisory Board. Joining the Grow Healthy Advisory Board ... of them embody the mission of our organization and bring talent, ... have them as we continue to expand our footprint as the ...
(Date:5/24/2016)... ... May 24, 2016 , ... Backed by decades of ... each job, ensuring the best suited solution to meet regulatory requirements. Their professional ... their lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s line of medical ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... Clarifying Vision - Prospects and ... Vision Care What can be expected from ... grow at the fastest rates? This visiongain ... trends, opportunities and prospects. ,Our 190-page ... most lucrative areas in the industry and the future ...
(Date:5/23/2016)... , May 23, 2016 ... reach USD 5.0 billion by 2022, according to a ... generation of medical waste coupled with the lack of ... is expected to drive the demand for reprocessed medical ... devices as compared to that of the original device ...
(Date:5/20/2016)... , May 20, 2016 ... Therapeutic Antibody Technologies, Insulins, Growth Hormones, Recombinant Coagulation ... Biological Drugs - This New Study Reveals Selling ... Ahead ,What is the future ... the latest technological and commercial analysis. Staying ahead ...
Breaking Medicine Technology: