Navigation Links
OHSU AIDS vaccine candidate appears to completely clear virus from the body

PORTLAND, Ore. An HIV/AIDS vaccine candidate developed by researchers at Oregon Health & Science University appears to have the ability to completely clear an AIDS-causing virus from the body. The promising vaccine candidate is being developed at OHSU's Vaccine and Gene Therapy Institute. It is being tested through the use of a non-human primate form of HIV, called simian immunodeficiency virus, or SIV, which causes AIDS in monkeys. Following further development, it is hoped an HIV-form of the vaccine candidate can soon be tested in humans. These research results were published online today by the journal Nature. The results will also appear in a future print version of the publication.

"To date, HIV infection has only been cured in a very small number of highly-publicized but unusual clinical cases in which HIV-infected individuals were treated with anti-viral medicines very early after the onset of infection or received a stem cell transplant to combat cancer," said Louis Picker, M.D., associate director of the OHSU Vaccine and Gene Therapy Institute. "This latest research suggests that certain immune responses elicited by a new vaccine may also have the ability to completely remove HIV from the body."

The Picker lab's approach involves the use of cytomegalovirus, or CMV, a common virus already carried by a large percentage of the population. In short, the researchers discovered that pairing CMV with SIV had a unique effect. They found that a modified version of CMV engineered to express SIV proteins generates and indefinitely maintains so-called "effector memory" T-cells that are capable of searching out and destroying SIV-infected cells.

T-cells are a key component of the body's immune system, which fights off disease, but T-cells elicited by conventional vaccines of SIV itself are not able to eliminate the virus. The SIV-specific T-cells elicited by the modified CMV were different. About 50 percent of monkeys given highly pathogenic SIV after being vaccinated with this vaccine became infected with SIV but over time eliminated all trace of SIV from the body. In effect, the hunters of the body were provided with a much better targeting system and better weapons to help them find and destroy an elusive enemy.

"Through this method we were able to teach the monkey's body to better 'prepare its defenses' to combat the disease," explained Picker. "Our vaccine mobilized a T-cell response that was able to overtake the SIV invaders in 50 percent of the cases treated. Moreover, in those cases with a positive response, our testing suggests SIV was banished from the host. We are hopeful that pairing our modified CMV vector with HIV will lead to a similar result in humans."

The Picker lab is now investigating the possible reasons why only a subset of the animals treated had a positive response in hopes that the effectiveness of the vaccine candidate can be further boosted.


Contact: Todd Murphy
Oregon Health & Science University

Related medicine news :

1. Walgreens to Help Provide Up to 3 Million Life-Saving Vaccines for Children who Need Them Most Through Donation to United Nations Foundation’s Shot@Life Campaign
2. Pain-free microneedle influenza vaccine is effective, long-lasting
3. African-American women less likely to receive HPV vaccine than whites, Pitt study finds
4. China Human Vaccine Industry Outlook 2012-2015: Worldwide Industry Latest Market Share, Strategy, Growth, Size, Trends And Forecast Research Report
5. Global Vaccine Market Trends and Disease Indications Analysis with 2022 Forecasts in New Research Report at
6. Investigational malaria vaccine found safe and protective
7. Global and China Human Vaccine Market Analysis & 2017 Forecasts in New Research Report at
8. Chinese CDC and Aeras sign agreement to collaborate on TB vaccine R&D
9. China Animal Vaccine Market Worth 15.9 Billion By 2016 in New Research Report at
10. Building Vaccine Accountability in Wisconsin Immunization Registry (WIR©â„˘) Systems with VTrckS
11. China Poultry Vaccine Industry Analysis in New Market Research Report at
Post Your Comments:
(Date:10/12/2015)... ... October 13, 2015 , ... Career Step, an online ... of its new Professional Medical Coding and Billing with Applied PCS career training ... ICD-10-PCS code sets, earn the Certified Professional Coder (CPC) and Certified Coding Associate ...
(Date:10/12/2015)... , ... October 12, 2015 , ... ... August 19, 2015, high school aged female athletes, particularly in the area of ... repetitive motion and mechanical overuse injuries than male peers in the same age ...
(Date:10/12/2015)... Los Angeles, CA (PRWEB) , ... October 12, 2015 , ... ... 7th, the Fire Chief for the city of San Antonio, Texas recommended that any ... retrofitted to incorporate these important safety systems going forward. The article explains that it ...
(Date:10/12/2015)... ... October 12, 2015 , ... AcousticSheep LLC, ... Cleveland Clinic in honor of Breast Cancer Awareness Month. During the month ... will donate a SleepPhones® Classic product to a breast cancer patient at the ...
(Date:10/12/2015)... (PRWEB) , ... October 12, 2015 , ... On July ... MN. Their mission: To paddle the entire 2,320-miles of river to the Gulf of ... halfway done with the monumental journey, with two months remaining for a November 22nd ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 12, 2015 Device usage in healthcare continues ... integrate these devices into existing clinical workflow. In response, ... and mobility solutions, has launched the SV10 series of ... a wide array of laptops and tablets. In addition, ... exclusively for Microsoft Surface and is compatible with all ...
(Date:10/12/2015)... October 12, 2015 ... to grow at 7.2% CAGR, microscopy market ... rising focus on nanotechnology, technological advancements, and ... report available with ... . --> Complete report on ...
(Date:10/12/2015)... Oct. 12, 2015 Indivior PLC (LON: INDV) today ... Delaware granted the Company,s motion to ... New Drug Application (ANDA) No. 205299 to market a generic ... naloxone) Sublingual Film (CIII) in the United States ... Since August 2013, Indivior has received Paragraph IV certifications from ...
Breaking Medicine Technology: