Navigation Links
OGI and MaRS Innovation invest in peptide therapeutics

Peptides and proteins have long been an attractive class of drug candidates because of their natural involvement in cellular processes and fewer potential side effects. Dr. Andrei Yudin, Professor, Department of Chemistry, University of Toronto, has developed a new and effective process that makes linear peptides circular, which allows these molecules, called macrocycles, to enter cells more effectively and increase their stability compared to linear peptides. Given their advantageous properties, macrocycles are emerging as a new class of molecules with potential in drug development.

Dr. Yudin and his group's unique ability to efficiently cyclize a broad range of linear peptides provides the opportunity to build a diverse library of macrocycles as possible drug candidates. The Yudin group will build a targeted library of macrocyles and test it for important properties including cell permeability and stability. This compound library will enable researchers and pharmaceutical organizations to screen for biologically active structures against disease-relevant targets, with the ultimate goal of identifying novel therapeutic macrocycles for new drug development. Dr. Yudin will be working closely with pharmaceutical companies to build a library that will meet the needs of industry.

"This work has the potential to help change the face of drug development and expand the options available in the creation of new therapeutics," commented Dr. Mark Poznansky, President and CEO, OGI. "Dr. Yudin and his group are clearly poised to be key influencers in this area."

"We are delighted to receive the investment from OGI as we move closer to commercialization," commented Dr. Yudin. "Our initial endeavour to generate a library of compounds is based around fundamental properties of drug-like compounds. Our method of cyclizing peptides will allow us to grow our inventory of compounds to eventually compete on a global scale in this emerging area of constrained peptides."

In addition to the PBDF funding, the technology has received investment by MaRS Innovation, the commercialization agent for 16 Ontario-based research institutions.

"We see significant appetite in the market for viable discovery platforms for peptide based therapeutics. It is important that Dr. Yudin receives appropriate support at this early stage to maximize the potential of this work," commented Dr. Rafi Hofstein, President and CEO, MaRS Innovation. "At MaRS Innovation, we work with many of the Province's leading researchers to convert great science into commercial opportunities."

U of T's Innovations and Partnerships Office (IPO) is working in collaboration with MI and Dr. Yudin to commercialize his novel platform technology.

"The University of Toronto is grateful to the Ontario Genomics Institute for this investment in our research," said Dr. Peter Lewis, Associate Vice President, Research at U of T and Acting Assistant Vice President, IPO. "The PBDF award will be vital in helping U of T and MaRS Innovation to bring Dr. Yudin's innovation to the marketplace. Just as importantly, OGI's support will assist greatly in enabling Dr. Yudin's work to make a strong and positive impact on global society."


Contact: Alastair Harris-Cartwright
Ontario Genomics Institute

Related medicine news :

1. Austen BioInnovation Institutes Accountable Care Community initiative gains national support
2. BUSM professor honored with Excellence and Innovation in Education and Training Award
3. Innovations in cardiovascular therapies and treatments will be presented at TCT 2011
4. Three senior Hebrew University faculty members receive Kaye Awards for innovations
5. QB3, Deloitte collaborate to drive California bioscience innovation
6. Innovation in science
7. Sones Innovation Award honors breast cancer vaccine research
8. Student innovation at Rensselaer Polytechnic Institute could lead to better breast cancer screening
9. ACP applauds President Obamas call for state innovation on health insurance coverage
10. How do data exclusivity periods affect pharmaceutical innovation?
11. SNM sharpens focus on molecular imaging innovation and translation
Post Your Comments:
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official ... independent group of Microsoft Dynamics SL software users, partners, industry experts and representatives. ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment ... itself for not only fulfilling the needs of advisers and clients but going ... price and providing top-tier customer service. However, there's always room for improvement, which ...
(Date:11/27/2015)... ... 27, 2015 , ... CBD College is proud to announce that ... awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join ... twelve colleges and universities in the state of California make the cut. CBD College ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Dr. ... Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., ... observed that both STEMI and Sepsis conditions present in similar ways and require time-critical ...
(Date:11/27/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class ... (Long Term Support) into its Q-Suite 5.10 product line. , Making the change ... version of Asterisk that will receive not only security fixes, but feature and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
(Date:11/26/2015)... -- 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ... transplantation is expected to boost the market growth, as 3D ... --> 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: