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NxStage Announces $43 Million Private Placement of Equity Securities
Date:5/23/2008

ot be offered or sold in the United States or any state thereof absent registration under the Securities Act and applicable state securities laws or an applicable exemption from registration requirements. As part of this transaction, NxStage has agreed to file a registration statement covering the resale of the shares of common stock and the shares of common stock issuable upon exercise of the warrants acquired in the private placement.

Important Additional Information

NxStage intends to file with the SEC a proxy statement in connection with the private placement. Investors and security holders of NxStage are urged to read the proxy statement when it becomes available because it will contain important information about NxStage and the private placement. Investors and security holders of NxStage may obtain free copies of the proxy statement when it becomes available at the SEC's website at http://www.sec.gov, at NxStage's website at http://www.nxstage.com or by writing to NxStage Medical, Inc., 439 S. Union St., 5th Floor, Lawrence, Massachusetts 01843, Attention: Investor Relations. NxStage, its directors and the affiliates of its directors may be deemed to be participants in the solicitation of proxies with respect to the private placement. A description of the interests in NxStage of its directors and such affiliates is set forth in NxStage's proxy statement for its 2008 annual meeting of stockholders, filed with the SEC on April 29, 2008, and will be set forth in the proxy statement in connection with the private placement when it becomes available.

About OrbiMed Advisors LLC

OrbiMed is the world's largest healthcare-dedicated fund manager. OrbiMed's investment advisory business was founded in 1989 with a vision to invest across the spectrum of healthcare companies: from private start-ups to large multinational companies. OrbiMed manages a
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SOURCE NxStage Medical, Inc.
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