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Nventa presents HspE7 data at international HPV conference
Date:11/5/2007

Preclinical Data Indicate New HspE7 Promotes More Potent Immune Responses

SAN DIEGO, CA, Nov. 5 /PRNewswire-FirstCall/ - Nventa Biopharmaceuticals Corporation (TSX:NVN) today presented additional preclinical data on new HspE7 at the 24th International Papillomavirus conference, the largest annual gathering of scientists, clinicians and companies working in the field of human papillomavirus (HPV), taking place this week in Beijing, China. HspE7 is being developed by Nventa as a therapeutic vaccine for the treatment of diseases caused by HPV. The paper titled, "Th1 CD4 Helper T Cell Immune Responses Induced by the Combination of HspE7 and the TLR-3 Agonist Poly ICLC", was presented by Peter Emtage, Ph.D., Vice President of Research and Development at Nventa.

Results: Data from the study not only confirmed that the addition of the TLR3 agonist Poly IC potently alters the magnitude of the antigen-specific CD8 effector arm, but also that adding this moiety acts to push the immune response into a more potent Th1-biased response. This was demonstrated by a significant reduction of Interleukin-5 (IL-5) levels seen following immunization with HspE7 co-administered with Poly IC, compared to those seen with HspE7 alone. Importantly, the IL-5 decrease was accompanied by a significant increase in the level of Interferon-gamma (IFN-gamma) in the Poly IC-containing HspE7 formulations. IFN-gamma is a hallmark cytokine associated with the generation of Th1-biased immune responses. In addition to the shift from IL-5 to IFN-gamma, there was also a significant increase in the generation of antigen-specific IL-2-secreting CD4 helper T cells. In the study, IgG1, IgG2b and IgG2c antibody responses were dramatically increased as well by the incorporation of Poly IC to the immunization.

Dr. Peter Emtage commented on the data: "Taken together, the antigen-specific increase in CD8 responses, CD4 helper T cell-derived cytokines, and the antigen-specific increase in IgG2b
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SOURCE Nventa Biopharmaceuticals Corporation
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