Navigation Links
Nventa presents HspE7 data at international HPV conference
Date:11/5/2007

Preclinical Data Indicate New HspE7 Promotes More Potent Immune Responses

SAN DIEGO, CA, Nov. 5 /PRNewswire-FirstCall/ - Nventa Biopharmaceuticals Corporation (TSX:NVN) today presented additional preclinical data on new HspE7 at the 24th International Papillomavirus conference, the largest annual gathering of scientists, clinicians and companies working in the field of human papillomavirus (HPV), taking place this week in Beijing, China. HspE7 is being developed by Nventa as a therapeutic vaccine for the treatment of diseases caused by HPV. The paper titled, "Th1 CD4 Helper T Cell Immune Responses Induced by the Combination of HspE7 and the TLR-3 Agonist Poly ICLC", was presented by Peter Emtage, Ph.D., Vice President of Research and Development at Nventa.

Results: Data from the study not only confirmed that the addition of the TLR3 agonist Poly IC potently alters the magnitude of the antigen-specific CD8 effector arm, but also that adding this moiety acts to push the immune response into a more potent Th1-biased response. This was demonstrated by a significant reduction of Interleukin-5 (IL-5) levels seen following immunization with HspE7 co-administered with Poly IC, compared to those seen with HspE7 alone. Importantly, the IL-5 decrease was accompanied by a significant increase in the level of Interferon-gamma (IFN-gamma) in the Poly IC-containing HspE7 formulations. IFN-gamma is a hallmark cytokine associated with the generation of Th1-biased immune responses. In addition to the shift from IL-5 to IFN-gamma, there was also a significant increase in the generation of antigen-specific IL-2-secreting CD4 helper T cells. In the study, IgG1, IgG2b and IgG2c antibody responses were dramatically increased as well by the incorporation of Poly IC to the immunization.

Dr. Peter Emtage commented on the data: "Taken together, the antigen-specific increase in CD8 responses, CD4 helper T cell-derived cytokines, and the antigen-specific increase in IgG2b
'/>"/>

SOURCE Nventa Biopharmaceuticals Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Updated GOLD report presents new understandings in diagnosis, treatment and prevention of COPD
2. The Art Of Maternity(TM) at Destination Maternity(R) Presents A Sacred Passage Into Motherhood; the Art of Belly Masking to Belly Casting
3. Presentation Time Correction: Keryx Biopharmaceuticals Presents at 12:00pm, ET Tomorrow (Oct. 3) at William Blair & Company Small-Cap Growth Stock Conference
4. VNUS Medical Technologies Presents at William Blair Small-Cap Growth Stock Conference
5. NARSAD - Worlds Leading Mental Health Research Charity - Presents 19th Annual New York Mental Health Symposium, Oct. 19th & 20th
6. Retirement Living TV Presents Sex, Drugs and Rock N Roll
7. AviaraDx Presents at 2007 BIOCOM Investor Conference
8. NARSAD - the Worlds Leading Mental Health Research Charity - Presents 2007 Prizes for Outstanding Psychiatric Research at New York Gala, October 19th
9. California Science Center Science Matters Speakers Program Presents The Science and Ethics of Fear
10. Borgata Heart & Soul Foundation Presents Third Annual Women in Wine Event
11. SafeSmart, Inc. Presents SafetyTies to Sixth Annual MedAssets Technology Forum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... a researcher from the Cancer Science Institute of Singapore ... identified the cancer specific stem cell which causes gastric ... new drugs for the treatment of this disease and ... by Dr Chan Shing Leng, Research Assistant Professor at ... cancer-specific variant of a cell surface protein, CD44v8-10, marks ...
(Date:4/23/2014)... Oncotarget , explored tumour heterogeneity where different ... signatures within the same cancer. Such differences could ... strategies. , Firstly they confirmed the mutual exclusivity ... or BRAF mutation. Secondly, they found that lung ... that specific mutation present uniformly throughout the tumour, ...
(Date:4/23/2014)... to the bottom of Alzheimer,s disease has been ... and controversies. In the latest crook in the ... into the interaction between proteins associated with the ... ACS Chemical Neuroscience , could have important ... Surewicz, Krzysztof Nieznanski and colleagues explain that for ...
(Date:4/22/2014)... recently FDA-approved device has been shown to reduce seizures ... 50 percent. When coupled with an innovative electrode placement ... facilitated the complete elimination of seizures in nearly half ... clinical trials. , That,s good news for a large ... living with epilepsy whose seizures can,t be controlled with ...
(Date:4/22/2014)... UT Southwestern Medical Center are making breakthroughs that could ... A team of physician-scientists at UT Southwestern has identified ... natural anti-depressant properties) works inside the brain. Simultaneously, the ... in the form of a neuroprotective drug known as ... April,s issue of Molecular Psychiatry, is notable ...
Breaking Medicine News(10 mins):Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment 2Health News:Newly approved brain stimulator offers hope for individuals with uncontrolled epilepsy 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 3
... in no real danger, survey finds , MONDAY, Aug. 20 ... white peers to take risks that boost their odds for ... August issue of the journal Archives of Dermatology , ... Medicine surveyed 369 high school students (221 white Hispanics and ...
... are exposed to more pro-tobacco advertising, according to a ... this months Public Health Reports. , Smoking remains ... the United States, causing more than 440,000 deaths annually ... indirect costs each year; African-Americans currently bear the greatest ...
... In a study likely applicable to men of other ... than 21 drinks per week) may increase the risk ... study are published in the latest issue of Annals ... Lydia Bazzano of Tulane University School of Public Health ...
... sounds like the latest cleaning sensation being hawked on ... get in your eyes. , But a few properly ... to diagnosing dry eye syndrome earlier than other methods, ... disease, new research at UT Southwestern Medical Center confirms. ...
... to new treatments, study says , SUNDAY, Aug. 19 ... most red, purple and blue fruits and vegetables, may help ... , In laboratory tests on rats and on human colon ... the growth of colon cancer cells. The team also found ...
... It affected 4 indicators of cardiovascular trouble, study found ... air drags down a number of "biological indicators" pointing ... shows. , The indicators include autonomic dysfunction, inflammation, oxidative ... was published Aug. 15 in the American Journal ...
Cached Medicine News:Health News:Hispanic Teens Take More Skin Cancer Risks 2Health News:Pitt study finds inequality in tobacco advertising 2Health News:Eye-staining technique offers early detection for dry eye syndrome 2Health News:Eye-staining technique offers early detection for dry eye syndrome 3Health News:Urban Smog Tough on Young Adults' Hearts 2
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
(Date:1/15/2014)... 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... application concerning composition of matter, biological targets, mechanism of ... death.  This patent application describes a ... molecules (VSRNAs) which interfere with the basic homeostatic cellular ...
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... , , ... Group (MRG), the global authority on medical technology market intelligence, ... enteral feeding devices will be a key driver of the ... MRG,s new US and European Markets for Enteral Feeding ...
... , FORT COLLINS, Colo., Dec. 14 ... 250 mg (chenodiol tablets). On October 22, 2009, ... an important therapy for patients suffering from gallstones in ... disease or advanced age. , Chenodal prescriptions have started ...
Cached Medicine Technology:Enteral Feeding Device Market To Generate More Than $700 Million in the US & Europe by 2014 2Enteral Feeding Device Market To Generate More Than $700 Million in the US & Europe by 2014 3Manchester Announces Availability of Chenodal(TM) 2
... German Craftsmanship have produced the ... world. Ocutek now makes them ... of the coveted Meisterbrief certificate, ... are qualified to become Ocutek ...
... of German Craftsmanship have produced ... the world. Ocutek now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: