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Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program

SAN CARLOS, Calif., June 5 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced the publication of preclinical data from the company's Wnt Therapeutics program showing that the R-spondin family of proteins activate the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. The R-spondin proteins also amplified the activity of Wnt proteins, and modulated the Wnt pathway by a common mechanism. The study, entitled "R-spondin Family Members Regulate the Wnt Pathway by a Common Mechanism," is published in the June issue of Molecular Biology of the Cell (MBC).

"This study reinforces the therapeutic potential of our R-spondin family of proteins in our Wnt therapeutics program, which target a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, bone disorders and wound healing," said Dr. Ted W. Love, chairman and chief executive officer of Nuvelo. "We are on track to begin two Phase 1 trials with NU206, the lead candidate in our Wnt Therapeutics program, in the second and third quarters of this year. We are also continuing to assess the therapeutic potential of other secreted proteins in the R-spondin family."

About R-spondin secreted proteins

The R-spondin (Rspo) family of secreted proteins are the first biologic agents that can be used to enhance endogenous Wnt signaling in vivo, and provide therapeutic potential in diseases that are dependent on the Wnt pathway for maintenance of tissue integrity and tissue repair. Rspo proteins are novel regulators of the Wnt pathway and were first identified by Nuvelo as potent gastrointestinal mitogens in transgenic mice (1).

About Nuvelo

Nuvelo, Inc. is dedicated to improving the lives of patients through the discovery, development and commercialization of novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor in Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and preclinical candidate NU206, a Wnt pathway modulator for the potential treatment of chemotherapy/radiation therapy-induced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and Wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities.

Information about Nuvelo is available at our website at or by phoning 650-517-8000.

This press release contains "forward-looking statements," which include statements regarding the timing, progress and anticipated completion of Nuvelo's clinical stage and research programs, the anticipated availability of top-line data, and the potential benefits that patients may experience from the use of our clinical stage compounds, which statements are hereby identified as "forward-looking statements" for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. Such statements are based on our management's current expectations and involve risks and uncertainties. Actual results and performance could differ materially from those projected in the forward- looking statements as a result of many factors, including, without limitation, uncertainties relating to drug discovery and the regulatory approval process; clinical development processes; enrollment rates for patients in our clinical trials; changes in relationships with strategic partners and dependence upon strategic partners for the performance of critical activities under collaborative agreements; and the impact of competitive products and technological changes. These and other factors are identified and described in more detail in Nuvelo's filings with the SEC, including without limitation Nuvelo's quarterly report on Form 10-Q for the quarter ended March 31, 2008 and subsequent filings. We disclaim any intent or obligation to update these forward-looking statements.

(1) Kim et al. (2005) Mitogenic influence of human R-Spondin1 on the

intestinal epithelium. Science 309.

SOURCE Nuvelo, Inc.
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