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Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program
Date:6/5/2008

SAN CARLOS, Calif., June 5 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced the publication of preclinical data from the company's Wnt Therapeutics program showing that the R-spondin family of proteins activate the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. The R-spondin proteins also amplified the activity of Wnt proteins, and modulated the Wnt pathway by a common mechanism. The study, entitled "R-spondin Family Members Regulate the Wnt Pathway by a Common Mechanism," is published in the June issue of Molecular Biology of the Cell (MBC).

"This study reinforces the therapeutic potential of our R-spondin family of proteins in our Wnt therapeutics program, which target a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, bone disorders and wound healing," said Dr. Ted W. Love, chairman and chief executive officer of Nuvelo. "We are on track to begin two Phase 1 trials with NU206, the lead candidate in our Wnt Therapeutics program, in the second and third quarters of this year. We are also continuing to assess the therapeutic potential of other secreted proteins in the R-spondin family."

About R-spondin secreted proteins

The R-spondin (Rspo) family of secreted proteins are the first biologic agents that can be used to enhance endogenous Wnt signaling in vivo, and provide therapeutic potential in diseases that are dependent on the Wnt pathway for maintenance of tissue integrity and tissue repair. Rspo proteins are novel regulators of the Wnt pathway and were first identified by Nuvelo as potent gastrointestinal mitogens in transgenic mice
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SOURCE Nuvelo, Inc.
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