Navigation Links
Nutritional intervention helps in mild Alzheimer's disease
Date:11/4/2011

A second clinical trial of the medical food Souvenaid confirmed that daily intake of the nutritional intervention improves memory in people with mild Alzheimer's disease (AD). Results of the trial - called Souvenir II - were presented at the 4th International Conference on Clinical Trials in Alzheimer's Disease (CTAD) in San Diego, California on Friday, Nov. 4, 2011 by Philip Scheltens, MD, PhD, Professor of Cognitive Neurology and Director of the Alzheimer Center at the VU University Medical Center in Amsterdam.

CTAD is sponsored by the University of California, San Diego School of Medicine and the European Alzheimer's Disease Consortium (EADC).

Souvenaid contains a patented combination of nutrients (Fortasyn Connect) specifically designed to stimulate the formation of nerve connections called synapses. Loss of synapses is thought by many Alzheimer's experts to be the underlying cause of memory loss and cognitive dysfunction in AD. Preclinical studies showed that the nutrients in Fortasyn Connect promote the growth of new brain synapses. Subsequently, in a study called Souvenir I, Souvenaid taken once per day over 12 weeks was shown to improve scores on standardized memory tests.

"I'm encouraged by the results of this second trial, but we need to do more analyses and further studies to fully understand the findings," said Scheltens. "These positive results give me the energy to go forward."

Souvenir II, conducted at 27 centers in six European countries, was designed to confirm that the benefits seen in Souvenir I persist for 24 weeks. The study also used a more comprehensive measure of memory, as well as other measures of brain activity. Participants in the blind study were randomly assigned to drink 125 ml. of Souvenaid or a control drink. Of the 259 subjects enrolled in the trial, 238 (91.9%) completed the study. Souvenaid was well tolerated, with 97% compliance among those who completed the study and a very favorable safety profile.

Memory performance was evaluated at baseline, 12 weeks and 24 weeks. The memory domain score of a Neuropsychological Test Battery (NTB) was the primary outcome parameter. This memory composite score was derived from the Rey Auditory Verbal Learning Test (immediate recall, delayed recall and recognition performance) and the Wechsler Memory Scale verbal paired associates test (immediate and delayed recall). Secondary outcomes resulting from the NTB were the executive function domain, total composite score and individual item scores.

During 24 weeks, memory composite scores from the Souvenaid group were significantly better than those from the control group. The significant effect on memory performance was confirmed by individual tasks of the NTB memory domain. Detailed analyses of secondary outcomes are still ongoing, including electroencephalogram (EEG) data as a measure of brain function. The EEG analysis, along with data from a magnetoencephalogram (MEG) sub-study may provide further understanding of the effect of Souvenaid on functional connectivity, thus investigating the hypothesis that Souvenaid can support synapse formation and function in mild AD.


'/>"/>
Contact: Jeffree Itrich
jitrich@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Baby-led weaning is feasible but could cause nutritional problems for minority of infants
2. World Renowned Physician Launches Dan-e™ All-Natural Nutritional Supplement for Women
3. Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements.
4. DRW Weight Loss Debuts Website to Promote Healthy Living and Nutritional Aids
5. O2 Media's Hit Morning TV Show ‘The Balancing Act' Welcomes Atkins Nutritionals to the Program
6. Are Fish Oil Supplements a Waste of Money? Healthy-Oil-Planet.com Helps Consumers Make Informed Decisions on Nutritional Supplements
7. Discover the Ease of Healthy Living Today with Juice Plus Nutritional Products
8. More Money, Increased Participation and Higher Nutritional Standards for School Meals
9. Small Nutritional Changes are a Key to Health, Weight Loss, says DSM Personalized Nutrition
10. Cell Science Systems Recruits Seasoned Executive to Head New Lifestyle Medicine & Nutritional Solution for Health Care Professionals
11. Nutritional Aid is Cost-effective Measure Against Health and Hunger Problems, World Vision Tells Congress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2019)... Calif. (PRWEB) , ... August 21, 2019 , ... An ... tourism and the very possible high cost of going abroad for cheap plastic surgery. ... Republic because the cost abroad was a fraction of what they would have paid ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... mascot from Morgantown, Pennsylvania, a lovable, socially popular, registered therapy dog, television ... called Never Bean Better Day. The Registrar at National Day Calendar has declared ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... technology: HDRX imaging. HDRX captures extremely high-resolution images of products for superior ... high image resolution at normal production line speeds within power settings used ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... Eminence Organic Skin Care products , the authorized retailer will change its corporate ... a practicing esthetician in Florida providing Eminence Organic Skin Care facials and treatments. ...
(Date:8/19/2019)... ... August 19, 2019 , ... Professional Enrollment Concepts (PEC), ... proudly announces they have ranked #3056 on the 2019 Inc. 5000 Fastest-Growing Private ... look at the most successful companies within the American economy's most dynamic segment—its ...
Breaking Medicine News(10 mins):
(Date:8/23/2019)... ... 22, 2019 , ... Fasting regimens have gained public and ... In a study published in Cell, Mount Sinai researchers found that fasting reduces ... acute infections. , While acute inflammation is a normal immune process that ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... Construction and Design Survey, has added Operational Readiness to its integrated service ... to clients’ capital projects, working with the clinical and operational leadership to ...
(Date:8/21/2019)... Ind. and RA'ANANA, Israel (PRWEB) , ... August ... ... announced they are entering into a partnership to enhance cybersecurity workforce education and ... , a hyper-realistic, simulated training platform for cybersecurity practitioners. Businesses in the United ...
Breaking Medicine Technology: