Navigation Links
Nutrition 21 Announces: University Of Arkansas Releases Independent, Placebo Controlled Vasodilation Study Showing 1.5g Of Nitrosigine is Equal to 8g of Citrulline Malate
Date:10/10/2019

In attendance at this year’s ISSN (International Society of Sports Nutrition) Annual Conference, Nutrition 21 was excited to hear the significant results of an independent study presented by researchers from the University of Arkansas studying the significant blood flow impact of Nitrosigine®. The clinical study poster entitled “The Acute Effects of Citrulline Malate and Bonded Arginine Silicate Supplementation on Vasodilation of Young Adults” was presented by lead author Jeffrey Rogers from the University of Arkansas American College of Sports Medicine. Nutrition 21 provided no support and did not participate in the design or implementation of the study.

The study compared two popular ingredients used in sports nutrition today: citrulline malate (CM ) and bonded arginine silicate (Nitrosigine®). Nitrosigine® is a leading branded ingredient used in a variety of consumer products with a legacy of continued success in the sports nutrition and pre-workout arena. Nitrosigine® is added to formulations in order to significantly increase serum arginine and nitric oxide (NO) levels, reduce markers of post-workout muscle damage and increase cognitive processing speed. CM is used for its ability to increase blood serum concentrations of arginine, resulting in NO production.

Dr. Michelle Gray, Associate Professor and the Director of the Exercise Science Research Center at the University of Arkansas, commented “Current research has yet to compare CM and Nitrosigine® in vivo using a flow-mediated dilation (FMD) technique, a validated measure of the vascular endothelium’s NO producing ability. We identified a need and designed the experiment with the purpose of determining the effectiveness of Nitrosigine® and CM compared to placebo, in up-regulating NO production in blood vessels as measured by acute changes in vasodilation.”

The double-blind, placebo-controlled, crossover design study was performed, with a 7-day washout period between test visits. The subjects were 22 healthy, normotensive, and at least moderately active male (n=14) and female (n=8) young adults.

Results showed that a single dose of 1.5g of Nitrosigine® significantly increased FMD, a measurement of increased vasodilation, blood flow, and possibly nitric oxide levels, more than placebo (p<0.01) and to the same extent as 8g of CM.

Overall Clinical Results of the Study:

  • In a double-blind, placebo-controlled study, both Nitrosigine® and CM supplementation led to an equally significant increase in vasodilation and blood flow, but with a dose of CM (8g) that was 5x more than the dose of Nitrosigine (1.5g)
  • Overall, these data show that a single dose of 1.5g of Nitrosigine®:
  • Significantly increases vasodilation and blood flow, important for increases in muscle pump, as measured by FMD,in active young adults compared to placebo
  • Significantly increases FMD, a nitric oxide-related measurement, in active young adults compared to placebo
  • Significantly increases FMD, a measurement of vasodilation, blood flow, and nitric oxide production, as well as 8g of CM increases those metrics

“Nutrition 21 was excited to hear of this independent study and the positive results showing the benefits of Nitrosigine® on increasing vasodilation, a process driven by increasing nitric oxide production, and believed to enhance a number of sports performance endpoints. We are especially pleased that this study was designed to test a healthy, athletically trained population, and showed that a 1.5g dose of Nitrosigine® worked as well as 8g of Citrulline Malate, in increasing flow mediated dilation.” says James Komorowski, MS, CNS, Chief Science Office at Nutrition 21.

About Nitrosigine®: Nitrosigine® is a patented complex of bonded arginine silicate with FDA New Dietary Ingredient (NDI) notification status and has been self-affirmed Generally Recognized As Safe (GRAS) at the level of 1,500 mg per day for use in nutritional bars and beverages. Nitrosigine® is scientifically engineered to boost nitric oxide levels, which have been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. The unique Nitrosigine® complex bonds arginine and silicate – unlocking powerful synergistic effects that offer enhanced benefits. Nitrosigine® is a safe, non-stimulant, effective ingredient that is easy to formulate into new and existing products for sports nutrition, men’s health and cardiovascular health.

About Nutrition 21, LLC: Nutrition 21, is an industry-leading developer and marketer of efficacious, high-value, clinically substantiated ingredients for use in dietary supplements, medical foods, and beverages. With over 30 years of biotechnology and pharmaceutical experience, the company’s scientific platform has continued to create unique, patented products that are both safe and clinically effective. To build consumer trust, Nutrition 21 ensures product efficacy and safety through a product development strategy that involves rigorous preclinical and clinical research. The company currently holds over 100 domestic and international issued and pending patents for its ingredients which support unique claims associated with glucose metabolism, weight management, cognition, and sports nutrition, among others. For more information, please visit: http://www.Nutrition21.com

© 2019 Nutrition 21, LLC Nitrosigine® is registered trademarks of Nutrition 21, LLC.

Nutrition 21, LLC, 1 Manhattanville Road, Suite 104, Purchase, New York 10577-2197 Source: Nutrition 21, LLC DRA2110100919

Read the full story at https://www.prweb.com/releases/nutrition_21_announces_university_of_arkansas_releases_independent_placebo_controlled_vasodilation_study_showing_1_5g_of_nitrosigine_is_equal_to_8g_of_citrulline_malate/prweb16637884.htm.


'/>"/>
Source: PRWeb
Copyright©2019 Vocus, Inc.
All rights reserved


Related medicine news :

1. How Untreated Hyperglycemia Can Lead to Kidney Failure and Disease Discussed in New Video From Health Nutrition News
2. Diet Doc’s Hormone Diets & Weight Loss Plans Offers New Uniquely Designed Diet Plans that are Nutritionally & Medically Compatible for Type 2 Diabetes Patients
3. Nutrition Science Initiative Recruits Exceptional Leader in Behavior and Metabolism
4. Integrative Nutrition Donates $117,000 in Support of GMO Labeling
5. Gaspari Nutrition Makes Waves at the 2013 World Jiu Jitsu Expo
6. An Intermittent Fasting Diet Plan That Yields the Quickest Weight Loss Results Revealed in New Video from Health Nutrition News
7. Secret to to Eating High Carb Foods While Losing Weight Revealed by Health Nutrition News
8. VeraVia Fitness Releases Nutrition Tips for Handling Stress
9. Cycles of Change Announces Nutritional and Wellness Plan
10. Prevo Health Solutions Sponsors Inaugural Quest for the Best Fitness and Nutrition Challenge for the Private Club Industry - Member and Club-to-Club Challenge
11. Healthy Snack Food Brand, Extend Nutrition, Tackles the Junk-Food Giants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2019)... ... ... Caring.com, a leading senior care referral service with Family Advisors nationwide, released ... Live. All 50 states and 302 cities in the U.S. were ranked based on ... According to the U.S. Census Bureau , almost 20 million Americans will be ...
(Date:10/8/2019)... ... 2019 , ... SoCal Adolescent Wellness announces the opening of a second location ... services to better serve the families in Orange County," said Becca Moody, CEO of ... extraordinary impact this pre-intervention program has on the lives of the adolescents and families ...
(Date:10/8/2019)... Hartford, CT (PRWEB) , ... October 08, 2019 ... ... at JawFixers in West Hartford, CT, help patients with missing teeth restore their ... year, this team of oral surgeons relies on advanced i-CAT® 3D Cone Beam ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... pathologists, 4medica® President Gregg Church will inform conference attendees how the ... labs orders management-by starting with the right, clean patient data. The single platform ...
(Date:10/8/2019)... Mass. (PRWEB) , ... October 08, 2019 , ... ... MCN Healthcare to seamlessly integrate skills and procedures content from ... designed to help nurses and allied health professionals master critical skills. MCN provides ...
Breaking Medicine News(10 mins):
(Date:10/11/2019)... ... October 11, 2019 , ... Based on data for the first eight ... in deceased organ donors over 2018. Through August 31, 7,786 deceased donors have provided ... national database . At this pace, the Association of Organ Procurement Organizations (AOPO) projects ...
(Date:10/10/2019)... (PRWEB) , ... October 10, 2019 , ... ... Parkinson Championships , 2019 ITTF Parkinson World Table Tennis Championships, October 11th – ... play music and perform in public. So, he sought to find a way ...
(Date:10/9/2019)... PARK, N.Y. (PRWEB) , ... October 09, 2019 ... ... will present the nation’s only complete teaching of Yoga Science and AMI Meditation ... Science of Yoga, this comprehensive training, held October 22-26, 2019 at the ...
Breaking Medicine Technology: