Navigation Links
Number of cancer stem cells might not predict outcome in HPV-related oral cancers

COLUMBUS, Ohio New research from The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) suggests that it may be the quality of cancer stem cells rather than their quantity that leads to better survival in certain patients with oral cancer.

The researchers investigated cancer stem cell numbers in oral cancers associated with human papillomavirus (HPV) and in oral cancers not associated with the virus. Typically, patients with HPV-positive oral cancer respond better to therapy and have a more promising prognosis than patients with HPV-negative tumors. The latter are usually associated with tobacco and alcohol use.

The OSUCCC James team's findings, published in the journal Cancer, suggest that relying on the number of cancer stem cells in a tumor might inaccurately estimate the potential for the tumor's recurrence or progression.

"We show that high levels of cancer stem cells are not necessarily associated with a worse prognosis in head and neck cancer, a finding that could have far-reaching implications for patient care," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology and scientist with the OSUCCC James Experimental Therapeutics Program.

Head and neck cancer is the sixth most common cancer worldwide, with an estimated 600,000 cases diagnosed annually. Although the disease is often linked to alcohol and tobacco use, cancer-causing types of HPV are a major risk factor for the malignancy, and cases of HPV-associated oral cancers have tripled in the past 30 years.

Cancer stem cells make up only a small percent of the malignant cells within a tumor. When these cells divide, they can produce either more cancer stem cells or the nondividing malignant cells that constitute the bulk of a tumor.

Research has shown that cancer stem cells are highly resistant to chemotherapy and radiation and those cancer stem cells that survive treatment cause tumor recurrence. For these reasons, it is thought that tumors with high numbers of cancer stem cells are more likely to recur.

In this study, Pan and his OSUCCC James collaborators hypothesized that patients with HPV-positive tumors had better outcomes because their tumors had fewer cancer stem cells than tumors with HPV-negative tumors. They discovered just the opposite, however.

Comparing numbers of cancer stem cells in human tumor samples and in oral-cancer cell lines, they found that the HPV-positive samples had 2.4 to 62.6 times more cancer stem cells than did the HPV-negative samples.

"Most cancer biologists would have expected tumors with high cancer stem cell numbers to be very difficult to cure because cancer stem cells are thought to convey resistance to conventional therapy," adds Ted Teknos, MD, study collaborator and director of head and neck cancer surgery at the OSUCCC James.

"However, it may be that HPV-induced head and neck cancer is highly curable primarily because the stem cells are sensitive to therapy. It's not the presence or absence of stem cells that is important in cancer, but rather how well does your therapy eliminate them."


Contact: Amanda J. Harper
Ohio State University Wexner Medical Center

Related medicine news :

1. Original Strength Listed As Number 1 Strength Training Book by Scott Iardella’s Rdella’s Training for 2013
2. HUMAN Ranks on Franchise 500 as Entrepreneur Magazine’s Number One Vending Franchise
3. The Law Offices of Sean M. Cleary Published an Infographic with Miami’s Emergency Phone Numbers
4. Crisis and Trauma Recovery Self-help Book by Renowned Therapist Tracie O’Keefe Becomes Number 1 Amazon Bestseller
5. Los Angeles Hair Transplant Surgeon Doubles the Number of Grafts in FUE Hair Restorations Producing More Efficient FUE Hair Transplantation
6. Stryker Hip Injury Claims Number Nearly 400 in Federal Court, Rottenstein Law Group LLP Reports
7. DePuy Hip Settlement News: Number of Federal Pinnacle Cases Now Exceeds 5,000, Rottenstein Law Group LLP Reports
8. Pradaxa Lawsuit News: Wright & Schulte LLC Reports on Growing Pradaxa Bleeding Litigation, As Number of Filings Exceed 1,800
9. Ross Insurance Offers Advice to Parents in an Effort to Help Reduce the Number of Teen Drinking and Driving Accidents
10. Heart Disease: The Number One Cause of Death in Diabetics Article and Video Released By Health News Wires
11. Bernstein Liebhard LLP Launches Stryker Hip Recall Website as Total Number of Rejuvenate, ABG II Hip Implant Lawsuits Nears 950 in U.S. Courts
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... Speech ... who believe that with innovative technologies and under the right circumstances, these practices ... the benefit of a dual-approach to his or her therapeutic sessions, as well ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... the 1980s we have seen vast improvements in scientific research and discoveries, leading ... strides, providing increased hope and relief to those affected by HIV/AIDS. Mediaplanet’s cross-platform ...
(Date:12/1/2015)... ... December 01, 2015 , ... The ... been lifted as IMAGE Information Systems launches MED-TAB™ -- the world’s first portable ... Meeting from November 29 to December 4, 2015. , MED-TAB is expected ...
(Date:12/1/2015)... ... December 01, 2015 , ... For many X-rays taken at ... accurate interpretation by the radiologist. The marking utensils are so small, however, they ... found a way to alleviate this problem. , He developed the patent-pending MARK ...
(Date:12/1/2015)... ... December 01, 2015 , ... SAN FRANCISCO, Calif. ... that the organization has awarded Education and Developmental Therapies (EDT), an Applied Behavior ... award celebrates exceptional special needs providers that excel in synthesizing the areas of ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015 Breg, ... and services, announced today that it has been awarded ... organization. Members served by Novation will have access to ... sports bracing products and soft goods dedicated to advancing ... --> The aging U.S. population, rising prevalence of ...
(Date:12/1/2015)... , Dec. 1, 2015 Building on ... Johnson & Johnson (NYSE: JNJ ) today ... Pharmaceutical Companies to significantly reduce the burden of ... up 74 percent of new HIV infections among ... World AIDS Day, these new initiatives include collaborations ...
(Date:12/1/2015)... YORK , Dec. 1, 2015 Relmada Therapeutics, ... the treatment of chronic pain, announced today that the company ... will be held December 1-3 at the Luxe Sunset Boulevard ... Sergio Traversa , CEO of Relmada Therapeutics, will present on ... Eastern Time). . Please register at least ...
Breaking Medicine Technology: