Navigation Links
Number of cancer stem cells might not predict outcome in HPV-related oral cancers
Date:1/22/2014

COLUMBUS, Ohio New research from The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) suggests that it may be the quality of cancer stem cells rather than their quantity that leads to better survival in certain patients with oral cancer.

The researchers investigated cancer stem cell numbers in oral cancers associated with human papillomavirus (HPV) and in oral cancers not associated with the virus. Typically, patients with HPV-positive oral cancer respond better to therapy and have a more promising prognosis than patients with HPV-negative tumors. The latter are usually associated with tobacco and alcohol use.

The OSUCCC James team's findings, published in the journal Cancer, suggest that relying on the number of cancer stem cells in a tumor might inaccurately estimate the potential for the tumor's recurrence or progression.

"We show that high levels of cancer stem cells are not necessarily associated with a worse prognosis in head and neck cancer, a finding that could have far-reaching implications for patient care," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology and scientist with the OSUCCC James Experimental Therapeutics Program.

Head and neck cancer is the sixth most common cancer worldwide, with an estimated 600,000 cases diagnosed annually. Although the disease is often linked to alcohol and tobacco use, cancer-causing types of HPV are a major risk factor for the malignancy, and cases of HPV-associated oral cancers have tripled in the past 30 years.

Cancer stem cells make up only a small percent of the malignant cells within a tumor. When these cells divide, they can produce either more cancer stem cells or the nondividing malignant cells that constitute the bulk of a tumor.

Research has shown that cancer stem cells are highly resistant to chemotherapy and radiat
'/>"/>

Contact: Amanda J. Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Original Strength Listed As Number 1 Strength Training Book by Scott Iardella’s Rdella’s Training for 2013
2. HUMAN Ranks on Franchise 500 as Entrepreneur Magazine’s Number One Vending Franchise
3. The Law Offices of Sean M. Cleary Published an Infographic with Miami’s Emergency Phone Numbers
4. Crisis and Trauma Recovery Self-help Book by Renowned Therapist Tracie O’Keefe Becomes Number 1 Amazon Bestseller
5. Los Angeles Hair Transplant Surgeon Doubles the Number of Grafts in FUE Hair Restorations Producing More Efficient FUE Hair Transplantation
6. Stryker Hip Injury Claims Number Nearly 400 in Federal Court, Rottenstein Law Group LLP Reports
7. DePuy Hip Settlement News: Number of Federal Pinnacle Cases Now Exceeds 5,000, Rottenstein Law Group LLP Reports
8. Pradaxa Lawsuit News: Wright & Schulte LLC Reports on Growing Pradaxa Bleeding Litigation, As Number of Filings Exceed 1,800
9. Ross Insurance Offers Advice to Parents in an Effort to Help Reduce the Number of Teen Drinking and Driving Accidents
10. Heart Disease: The Number One Cause of Death in Diabetics Article and Video Released By Health News Wires
11. Bernstein Liebhard LLP Launches Stryker Hip Recall Website as Total Number of Rejuvenate, ABG II Hip Implant Lawsuits Nears 950 in U.S. Courts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... 2014 It’s hard to imagine what it’s ... vulnerable children around the world, it’s a reality. And while ... children are forced to walk barefoot on rocky terrain or ... play with their friends. , Buckner International's Shoes ... Radio in October to encourage support for Air1 and ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... 2014 Recently, Top10BestSEOHosting.com has unveiled ... JustHost, GoDaddy and HostMonster are the best VPS ... Private Server) is the method of partitioning a ... which has the appearance and capabilities of running ... the site pays close attention to VPS products ...
(Date:10/19/2014)... stem cell-based research could improve understanding of intestinal diseases ... suggests. Scientists used stem cells to grow "organoids" ... They then transplanted the organoids into mice, creating a ... researchers. "This provides a new way to study ... failure, from genetic disorders appearing at birth to conditions ...
Breaking Medicine News(10 mins):Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Scientists Grow, Implant Human Intestinal Tissue in Mice 2
... A new approach of imaging discovered by scientists now detects even small smoking-related lung ... track deep into the smokers lungs and its movement - researchers at the University ... images of lungs soft tissues, when helium gas was inhaled prior taking images. ... ...
... anti-quota strike, setting the stage for a face-off with the ... the 19-day long protest can invite contempt proceedings. ... General Body Meetings of the medicos which saw sharp divisions ... has paralysed medical services in the capital., ,'The Youth ...
... incidence of HIV/AIDS is declining in the western Indian state ... , Karnataka and Andhra Pradesh because of the proactive measures ... in the country, especially in the north, it is rising, ... released Tuesday, said that overall two-thirds of the people living ...
... Court of India today asked the students to end their ... if they fail to do so contempt// action can be ... told that their protest had left "patients at the mercy ... are continuing with the strike. If they are over-reaching our ...
... Myanmar into India's northeast has led to a rise in ... says a United Nations study. ,"Drug trafficking across the ... Mizoram and Nagaland occurs with ease. Despite the existence of ... accessible to the local youths of these states," said a ...
... planning to study the effect of cervical cancer on the ... as the biggest study into the psychological and emotional effects ... will be instituted for duration of five years and will ... physical lives of couples. The researchers have said that they ...
Cached Medicine News:Health News:Helium And MRI Scanning Clearly Detects Smoker Lungs – Research Find 2Health News:Supreme Court Warns Medicos of Contempt Action 2Health News:Illegal Drug Trafficking Pose A Great Threat For HIV Epidemic In Northeast 2
(Date:10/20/2014)... , Oct. 20, 2014  ResMed (NYSE: ... the ResMed Data Exchange program, a comprehensive suite ... equipment (HME) and other health care providers. ... access to critical patient information. It integrates valuable ... and U-Sleep™ patient management platforms with customers, in-house ...
(Date:10/20/2014)... Oct. 20, 2014 Lpath, Inc. (NASDAQ: ... bioactive lipid-targeted therapeutics, received official notification from the European ... another key patent supporting its iSONEP™ and ASONEP™ ... European patent No. 2087002, claims compositions of matter ... two lead compounds, iSONEP and ASONEP. Sonepcizumab is ...
(Date:10/19/2014)... -- Shire plc (LSE: SHP, NASDAQ: SHPG ... (CFO), has notified the Board of Directors of his decision to ... opportunity as CFO of Severn Trent plc.  James will leave Shire ... a search for a new CFO immediately. Flemming Ornskov, ... and lead a high-quality finance team at Shire. We are very ...
Breaking Medicine Technology:ResMed Launches ResMed Data Exchange 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 4Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4
... GlySure Limited, developer of in-hospital continuous ... its $10.9 million Series C financing round. GlySure will ... approval in the United States and Europe. ... well as existing investors Amadeus Capital Partners, Chester Investments ...
... -- Global Pharm Holdings Group, Inc. (OTCBB: GPHG) ... integrated pharmaceutical company engaged in the distribution of ... herbal cultivation and sales in China through its ... today announced the appointment of Mr. Kwong Chi ...
Cached Medicine Technology:GlySure Secures $10.9 Million in Series C Financing Round 2Global Pharm Holdings Group, Inc. Strengthens its Board by Adding a Non-Executive Director 2Global Pharm Holdings Group, Inc. Strengthens its Board by Adding a Non-Executive Director 3
Sabre 180 is a powerful niche generator....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Malis CMC-III Generator provides both coagulation and cutting outputs....
Medicine Products: