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Number of babies mom has may play role in future cardiovascular health
Date:3/28/2014

her or not women had evidence of subclinical atherosclerosis in the heart and artery walls. CAC was positive if it was greater than 10 and AWT was abnormal if it was greater than the 75th percentile for age and gender. These tests were done as part of standard subject participation in the Dallas Heart Study.

Using women who had two or three live births as a reference, women who had given birth to four or more children had an approximately two-fold increased risk of having abnormal CAC or AWT. This association remained even after adjusting for socioeconomic status, education, race and factors known to heighten the risk of cardiovascular disease. Women who had more babies were more likely to be older, Hispanic, have high blood pressure, higher body mass index and lower socioeconomic status.

Curiously, women who had zero or just one live birth were also more likely to show evidence of subclinical atherosclerosis revealing a U-shaped relationship.

Authors say it is unclear why this might be the case. But Sanghavi and others speculate they may have captured some women in this group who have an underlying condition that prevents them from carrying a first or second pregnancy to term, which may also predispose them to cardiovascular disease or risk factors. For example, women with polycystic ovarian syndrome can have menstrual irregularities and trouble getting pregnant, but they may also have other health changes such as excess body weight, diabetes, high blood pressure or high cholesterol.

Pregnancy itself sparks a cascade of changes that can place more strain on a woman's cardiovascular system. For example, the volume of blood being pumped through the heart increases by 50 percent. In addition, other physiological and metabolic changes occur (e.g., increased insulin resistance and higher cholesterol levels).

"Pregnancy has been called 'nature's stress test,' and for good reason," Sanghavi said. "It may also help identify
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Contact: Beth Casteel
bcasteel@acc.org
202-375-6275
American College of Cardiology
Source:Eurekalert

Page: 1 2 3

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