Navigation Links
Nuclear receptors reveal possible interventions for cancer, obesity
Date:1/10/2011

HOUSTON, Jan. 10, 2011 Research with significant implications in the treatment and intervention of cancer and obesity has been published recently in two prestigious journals by University of Houston (UH) biochemist Dr. Jan-ke Gustafsson.

In an invited review in the Journal of Biological Chemistry, the most-cited biomedical research journal in the world, Gustafsson and his team summarize the most recent results pertaining to the function of a nuclear receptor called estrogen receptor beta, or ERbeta, the biological and medical importance of which Gustafsson and his associates discovered in 1995. In the article, titled "Estrogen Signaling via Estrogen Receptor Beta," the group found that this regulatory molecule prevents what is called epithelial-to-mesenchymal transition, or EMT, in the prostate gland. EMT is believed to have an essential role in prostate tumor development. ERbeta also has a growth-suppressive effect in colon cancer cells.

All of this, added to new insights gained by the researchers regarding ERbeta's interaction with certain genetic materials, suggests that this molecule is potentially an interesting pharmaceutical target in many diseases, including cancer.

A second article by Gustafsson and his group appeared in a recent issue of the journal Proceedings of the National Academy of Sciences, one of the world's most-cited multidisciplinary scientific serials. Titled "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity," the research shows that two specific nuclear receptors LXRalfa and LXRbeta act in such a way as to indicate they have a crucial role in regulating energy homeostasis, which is important to maintain the stability of normal biological states during adjustments to environmental changes. Gustafsson suggests, then, that these molecules should be considered as targets in pharmaceutical intervention against obesity.

Both s
'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Accurate interpretation of antinuclear antibodies test key to confirming autoimmune disease
2. SNM and Image GentlyTM launch initiative to standardize radiation dose in pediatric nuclear medicine
3. New nuclear breast imaging technologies associated with higher cancer risks
4. NIH renews research program to develop medical countermeasures against radiological, nuclear threats
5. SNMs 2010 Annual Meeting reveals latest developments in molecular imaging and nuclear medicine
6. Sung-Cheng (Henry) Huang receives 2010 Benedict Cassen Prize for Research in Nuclear Medicine
7. Bengt Roland Långström receives SNMs 2010 Georg Charles de Hevesy Nuclear Pioneer Award
8. UND Acquires ProtectionPlus in Ongoing Effort to Reduce Nuclear Stress Testing Costs for Physicians
9. Applied nuclear physics for biomedicine, nuclear security and basic science
10. H1N1, Biodegradable Plastics and Nuclear Physics Highlight Research Areas Undertaken During Houghton College's Summer Research Institute
11. Urgent Nuclear Stress Test Lab Costs Reductions for Physician Practices in Need
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nuclear receptors reveal possible interventions for cancer, obesity
(Date:4/17/2015)... (PRWEB) April 17, 2015 Baptist Health ... have signed a partnership agreement designed to transform oncology ... The institutions have agreed to create a joint cancer ... protocols and translational research. Baptist MD Anderson Cancer Center ... providing a single destination for highly coordinated, multidisciplinary cancer ...
(Date:4/17/2015)... Scientists from the Icahn School ... U.S. and Venezuelan researchers, have discovered the most ... an isolated tribe of Yanomami Amerindians in the ... the Yanomami, previously unexposed to antibiotics or industrialized ... of people living in industrialized countries, and was ...
(Date:4/17/2015)... Connie Casad, M.D., a well-known and respected gynecologist, ... years of practice experience in Dallas, Texas, has announced ... for her patients with the availability of a reader’s ... with a brief synopsis on each for her patients. ... providing this service, Dr. Casad said, “Furnishing a researched ...
(Date:4/17/2015)... April 17, 2015 Compare-autoinsurance.org has released ... best online auto insurance quotes . , ... financial coverage for their cars. Drivers should always compare ... buy. The insurance market is a competitive one, which ... every hour. , It is now possible to ...
(Date:4/17/2015)... 2015 Oxytocin is a ... and thought to help mothers bond to their newborn, ... substantiate this, new studies performed, at NYU Langone Medical ... reported by Medical News Today on April 16, 2015, ... maternal social behavior. The study reveals that, when oxytocin ...
Breaking Medicine News(10 mins):Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 2Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 3Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3Health News:Connie Casad, M.D. Provides Patients Recommended List of Wellness Books on Website 2Health News:The Best Auto Insurance Quotes Are Available Online! 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 3
... ... is guaranteed to make acne disappear in days thanks to Capsaicin, the ... pending combination of capsaicin and caffeine to increase topical blood flow and ... that causes acne without any burn. The company is so confident of ...
... ... ... , ... , , , ...
... , ... ... ... ...
... , ... ... ... ...
... MAYWOOD, Ill. -- Loyola University Medical Center ranked ... recent research competition for pathologists in training. Loyola ... number of scientific studies accepted in the Stowell-Orbison Awards ... of Pathology (USCAP). One hundred academic programs worldwide participated ...
... various illnesses , FRIDAY, Feb. 19 (HealthDay News) -- ... the intestinal tract from bacterial infection and inflammation has ... the protein -- granulocyte-macrophage colony-stimulating factor (GM-CSF) -- ... by pathogens such as E. coli and intestinal inflammation ...
Cached Medicine News:Health News:ThermaSkin Offers Free Natural Pepper Remedy To Acne Sufferers 2Health News:ThermaSkin Offers Free Natural Pepper Remedy To Acne Sufferers 3Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 260,500 Square Foot Medical Office Portfolio in Indiana 2Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 260,500 Square Foot Medical Office Portfolio in Indiana 3Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 260,500 Square Foot Medical Office Portfolio in Indiana 4Health News:Labopharm announces underwriters' exercise of over-allotment option for recent public offering 2Health News:Labopharm announces underwriters' exercise of over-allotment option for recent public offering 3Health News:Labopharm announces underwriters' exercise of over-allotment option for recent public offering 4Health News:Labopharm announces underwriters' exercise of over-allotment option for recent public offering 5Health News:Cunard's Queen Victoria is 'Pretty in Pink' in Sydney 2
(Date:4/17/2015)... April 17, 2015   IBA Molecular, a ... announced today that it has signed a definitive agreement ... Inc. (IBAM NA), to Illinois Health and Science (IHS). Under ... an independent company headquartered in Dulles, Virginia ... advantage of new product and footprint synergies. IBA Molecular ...
(Date:4/17/2015)... DUBLIN , Apr. 16, 2015 Research and ... addition of the "Corporate Reputation of Pharma in ... - 1st Edition" report to their offering. ... has compared opinions on the corporate reputation of the ... in mental health with the views of patient organisations ...
(Date:4/17/2015)... , April 17, 2015 Bionomics Limited ... and development of innovative therapeutics for the treatment of ... announced the presentation of data from three of its ... for Cancer Research (AACR) 106 th Annual Meeting ... Philadelphia, PA USA. The ...
Breaking Medicine Technology:Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5
... , ST. LOUIS, Oct. 30 Stereotaxis received notice ... CE Mark for distribution in the European market. ... from the on-going co-development agreement between Stereotaxis and Biosense ... use in the Niobe Magnetic Navigation System (MNS). ...
... Inc. (NYSE: MTD ) today announced third quarter results for ... in local currency declined by 12% in the quarter. Reported ... , Net earnings per diluted share as reported (EPS) ... Adjusted EPS was $1.36, a 6% decline from the prior-year ...
Cached Medicine Technology:Stereotaxis Receives Notice of European Approval of an Additional Magnetic Irrigated Catheter 2Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 2Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 3Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 4Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 5Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 6Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 7Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 8Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 9Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 10Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 11Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 12Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 13
Solid 14 mm free-swinging blades, suture posts, and stabilizing disk. Dull finish....
Designed for use with foster enucleation snare (E3670). Package of 12 stainless steel wires. Overall length 5.3 inches....
Open ring design for globe fixation during various ocular procedures. Blunt fixation points. Swivel handle provides increased flexibility. Manufactured in titanium....
Adult size. Loops retract lids. Polished finish....
Medicine Products: